Epidemiologic research on the association between dietary habits, non-communicable diseases, and metabolomics of blood and urine.

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K24254
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0908:Society medicine, nursing, and related fields
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Okami Yukiko 滋賀医科大学, 医学部, 特任助教 (60591401)
• Project Period (FY): 2019-08-30 – 2023-03-31
• Keywords: 栄養疫学 / メタボローム / リポたんぱく質 / High Density Lipoprotein / 魚由来オメガ3脂肪酸 / 国際共同研究

Outline of Final Research Achievements

Serum metabolomic analysis was performed on 1,307 Japanese and Japanese-American INTERLIPID participants. The most different serum lipoproteins between Japanese and Japanese-Americans were small HDL4 concentrations in both men and women; HDL4 concentrations were inversely correlated with fish omega-3 polyunsaturated fatty acid intake, and Japanese people had lower HDL4 concentrations than Japanese-Americans. Adjustments for age, gender, country, BMI, alcohol consumption, smoking status, physical activity, and other nutrients did not change the results, and no interaction effects of these variables were observed. The clinical significance of HDL4 concentrations will be investigated in the future.

Free Research Field

栄養疫学

Academic Significance and Societal Importance of the Research Achievements

遺伝的に類似し、環境要因の異なる日本人とハワイ在住日系米人を比較したところ、男女ともに最小径HDL4が最も異なった。また、日本人が日系米人よりHDL4濃度が低い理由として、高い魚の摂取量が一要因として考えられた。HDL粒子サイズの臨床的意義は謎であるが、先行研究より最小径HDL4は循環器疾患の危険因子またはマーカーである可能性はある。また、HDL粒子サイズや最大径HDL1は魚摂取量のマーカーとして捉えられる可能性もあり、今後さらなる検証が必要である。