Branched-chain amino acid ingestion suppresses detraining-induced mitochondrial reduction

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K24310
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0909:Sports sciences, physical education, health sciences, and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: MATSUNAGA Yutaka 東京大学, 大学院総合文化研究科, 助教 (10850133)
• Project Period (FY): 2019-08-30 – 2022-03-31
• Keywords: ミトコンドリア / BCAA / トレーニング休止 / 骨格筋

Outline of Final Research Achievements

Detraining reduces mitochondrial content in skeletal muscle. The strategy to suppress detraining-induced mitochondrial reduction has not been yet fully elucidated. We evaluated whether branched-chain amino acid (BCAA) ingestion could have a beneficial impact on detraining-induced mitochondria reduction. Our results suggest that BCAA ingestion suppresses detraining-induced mitochondrial reduction partly through inhibiting mitophagy.

Free Research Field

スポーツ科学

Academic Significance and Societal Importance of the Research Achievements

ミトコンドリアの量・質の低下は、糖尿病などの代謝疾患の発症や、持久的運動パフォーマンスの低下に関わる。本研究結果から、BCAAの新たな生理作用の発見につながることや、ミトコンドリア減少を抑制する栄養摂取方法を提供する一助になることが期待される。