2012 Fiscal Year Final Research Report
Study of Mechanisms of Cellular Mechanosensing
| Project/Area Number |
20001007
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| Research Category |
Grant-in-Aid for Specially Promoted Research
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
Engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
SATO Masaaki 東北大学, 大学院・医工学研究科, 教授 (30111371)
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| Co-Investigator(Kenkyū-buntansha) |
OHASHI Toshiro 北海道大学, 大学院工学研究院, 教授 (30270812)
KANNZAKI Makoto 東北大学, 大学院医工学研究科, 准教授 (10272262)
DEGUCHI Shinji 東北大学, 大学院工学研究科, 准教授 (30379713)
SAKAMOTO Naoya 川崎医療福祉大学, 医療技術学部, 准教授 (20361115)
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| Co-Investigator(Renkei-kenkyūsha) |
ADACHI Taiji 京都大学, 再生医科学研究所, 教授 (40243323)
OGURA Toshihiko 東北大学, 加齢医学研究所, 教授 (60273851)
OHASHI Kazumasa 東北大学, 大学院生命科学研究科, 准教授 (10312539)
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| Project Period (FY) |
2008 – 2012
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| Keywords | バイオメカニクス / バイオイメージング / 生体物性 / 細胞骨格 / 細胞内情報伝達 / メカノバイオロジー / ストレスファイバー / メカノセンサ |
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| Research Abstract |
There are many cells sensing mechanical forces in our body and the cells control the functions of tissues and organs to be adapted to mechanical environment. However, the mechanisms were not elucidated yet. In this study, we mainly focused on vascular endothelial cells, osteocytes and myocytes. It became clear that cell-cell and focal adhesions and cytoskeletons such as stress fiber are working as mechanosensors and some proteins in cytoplasm were identified as signal messengers. Mechanical forces were also playing important roles in organogenesis such as valve formation in cardiovascular system.
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