Identification of Epileptogenic Focus by Employing Softcomputing and Establishment of Minimally Invasive and Definitive Surgery

2011 Fiscal Year Final Research Report

• Project/Area Number: 20001008
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering; Engineering
• Research Institution: Kyushu Institute of Technology
• Principal Investigator: YAMAKAWA Takeshi 九州工業大学, 大学院・生命体工学研究科, 継続研究員 (00005547)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Michiyasu 山口大学, 大学院・医学系研究科, 教授 (80196873) ; YAMAKAWA Toshitaka 静岡大学, 工学部, 助教 (60510419)
• Co-Investigator(Renkei-kenkyūsha): AOU Shuji 九州工業大学, 大学院・生命体工学研究科, 教授 (40150908) ; ISHIZUKA Satoru 九州工業大学, 大学院・生命体工学研究科, 准教授 (40124804) ; HORIO Keiichi 九州工業大学, 大学院・生命体工学研究科, 准教授 (70363413) ; FUJII Masami 山口大学, 医学部附属病院, 准教授 (90181320) ; NOMURA Sadahiro 山口大学, 医学部附属病院, 講師 (20343296) ; OWADA Yuji 山口大学, 大学院・医学系研究科, 教授 (20292211)
• Research Collaborator: GRIGORIEVICH Zimin lev 九州工業大学, 大学院・生命体工学研究科, ポスドク (90380724) ; TOKIWA Tatsuji 九州工業大学, 大学院・生命体工学研究科, ポスドク (00636219) ; INOUE Takao 山口大学, 大学院・医学系研究科, 学術研究員 (80513225) ; MARUTA Yuichi 山口大学, 大学院・医学系研究科, 助教 (30543970) ; FUJIOKA Hiroshi 山口大学, 大学院・医学系研究科, 助教 (20544737)
• Project Period (FY): 2008 – 2011
• Keywords: 難治性てんかん / 抗てんかん薬 / 後遺障害 / 低侵襲治療法 / てんかん原性域 / 逆問題 / 瞬間凍結融解壊死 / レーザー焼灼

Research Abstract

The patients comprising about 0. 2% of the total population, in the country or overseas, are insensitive to antiepileptic drug and left to the surgical operation. The operation often causes a residual disability because of its accuracy of epileptogenic focus estimation and extirpation with some margin. Our project was dedicated to seeking for the accurate estimation method of the focus and the surgical procedure including the flash freeze-thaw technology and the laser ablation technology.

Research Products

• [Journal Article] Cell Necrotization in Rat Brain by The Cryogenic Probe (2012)
  • Author(s): Satoru Ishizuka, Hiroaki Koga, Zimin Lev Grigorievichi, Takeshi Yamakawa
  • Journal Title: International Journal of Intelligent Computing in Medical Sciences and Image Processing Volume: Vol.18 Pages: 166-171
  • Peer Reviewed
• [Journal Article] Disappearance of Epileptic Bursts on Rat Hippocampal Slices by Using Laser Irradation (2012)
  • Author(s): Yuya Hirayama, Satoru Ishizuka, Zimin Lev Grigorievich, Takeshi Yamakawa
  • Journal Title: International Journal of Intelligent Computing in Medical Sciences and Image Processing Volume: Vol.18 Pages: 155-164
  • Peer Reviewed
• [Journal Article] Cooling of the Epileptic Focus Suppresses Seizures with Minimal Influence on Neurological Functions (2012)
  • Author(s): M. Fujii, T. Inoue, S. Nomura, Y. Maruta, Y. He, T. Yamakawa, M. Suzuki
  • Journal Title: Epilepsia Volume: Vol.53 Pages: 485-493
  • Peer Reviewed
• [Journal Article] Multi-space Competitive DGA for Model Selection and its Application to Localization of Multiple Signal Sources (2011)
  • Author(s): Shudai Ishikawa, Tatsuji Tokiwa, Keiichi Horio, Takeshi Yamakawa, 他2名
  • Journal Title: Journal of Advanced Computational Intelligence and Intelligent Informatics Volume: Vol.15, No.6 Pages: 1320-1328
  • Peer Reviewed
• [Journal Article] Subdural Electrocorticogram Measurement with a Minimally-Invasive Procedure using an SMA-Manipulated Microelectrode Array (2011)
  • Author(s): Toshitaka Yamakawa, Takeshi Yamakawa, S. Aou, S. Ishizuka, M. Suzuki, M. Fujii, T. Aoki
  • Journal Title: Advanced Materials Research Volume: Vol.222 Pages: 313-317
  • Peer Reviewed
• [Journal Article] Investigation of the mechanism of polar excitations on frog sciatic nerve by optical stimulation (2010)
  • Author(s): Yuya Hirayama、Satoru Ishizuka, Zimin Lev Grigorievich, Takeshi Yamakawa, Toshitaka Yamakawa
  • Journal Title: Advanced Materials Research Volume: Vol.222 Pages: 281-285
  • Peer Reviewed
• [Journal Article] Focal brain cooling terminates the faster frequency components of epileptic discharges induced by penicillin G in anesthetized rats
  • Author(s): Hiroyuki Kida, Masami Fujii(2), Sadahiro Nomura(6), Takeshi Yamakawa(10), Michiyasu Suzuki(11), 他5名
  • Journal Title: Clinical Neurophysiology Volume: (in press)
  • Peer Reviewed
• [Presentation] Cooling of the Epileptic Focus Suppresses Seizures with Minimal Influence on Neurological Functions (2011)
  • Author(s): Masami Fujii
  • Organizer: 2011 American Epilepsy Society Annual Meeting
  • Place of Presentation: Baltimore Convention Center, USA
  • Year and Date: 2011-12-01
• [Presentation] Cool the Brain : A novel strategy to control the abnormal brain activity (2011)
  • Author(s): Toshitaka Yamakawa
  • Organizer: 12th International Young Scientists Conference Optics and High Technology Material Science
  • Place of Presentation: Kyiv University, Ukraine
  • Year and Date: 2011-10-28
• [Presentation] Identification of epileptic focus with multi-channel near-infrared spectroscopic topography(optic topography) (2011)
  • Author(s): Y. Maruta
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Marriott Rome Park Hotel, Italy
  • Year and Date: 2011-08-29
• [Presentation] Development of minimally invasive surgery for intractable epilepsy (2009)
  • Author(s): Takeshi Yamakawa
  • Organizer: SPIE Defense, Security Sensing 2009
  • Place of Presentation: Orlando, USA
  • Year and Date: 2009-04-16
• [Book] 別冊・医学のあゆみてんかん治療Update研究と臨床の最前線「てんかんの新しい治療:局所脳冷却療法」 (2011)
  • Author(s): 藤井正美、鈴木倫保
  • Total Pages: 116-122
  • Publisher: 医歯薬出版
• [Book] 今日の治療指針『てんかんの外科治療』 (2010)
  • Author(s): 藤井正美
  • Total Pages: 743-744
  • Publisher: 医学書院
• [Remarks] 山川烈,功労賞,バイオメディカル・ファジィ・システム学会, 2011年10月29日.受賞
• [Remarks] Yuya Hirayama, Inter-Academia2009 Young Researchers Award, 8th International Conference on Global Research and Education, 2009年9月16日.受賞
• [Remarks] Takeshi Yamakawa, Biomedical Wellness Award, SPIE Conference, SPIE Conrference, 2009年4月13日.受賞
• [Remarks] 「てんかん治療に新しい手法」, NHK北九州「こんばんは北九州」, 2011年12月20日放送.報道関連
• [Remarks] 「てんかん新治療法開発へ九工大など開頭せず針で患部破壊」,読売新聞・山口版(夕刊), 2008年7月18日掲載.報道関連
• [Remarks] 『「てんかん患者と家族のためのシンポジウム-てんかん治療の原点は新しい情報の収集と強い意志-」第2回CADETシンポジウム』, 2011年3月26日実施,九州工業大学,参加者数:207名.公開行事
• [Remarks] "International Workshop on Advanced Epilepsy Treatment(CADET2009)," 2009年3月28-30日実施,北九州学術研究都市会議場,参加者数:185名.公開行事
• [Remarks] ホームページ研究代表者のホームページ
  • URL: http://www.kyutech.ac.jp/professors/wakamatsu/w2/w2-2/entry-748.html
• [Patent(Industrial Property Rights)] 脳信号計測システム、生体内計測装置及び脳信号計測位置制御方法 (2011)
  • Inventor(s): 山川俊貴,山川烈
  • Industrial Property Rights Holder: 国立大学法人九州工業大学
  • Industrial Property Number: 特許、PCT/ JP2011/ 51237
  • Filing Date: 2011-01-24
  • Overseas
• [Patent(Industrial Property Rights)] 完全埋め込み型局部冷却装置 (2009)
  • Inventor(s): 藤岡裕士,藤井正美,鈴木倫保,斉藤俊
  • Industrial Property Rights Holder: 国立大学法人山口大学
  • Industrial Property Number: 特許、特願2009-236290
  • Filing Date: 2009-10-13
• [Patent(Industrial Property Rights)] 冷却操作用針状プローブおよび冷却操作システム (2009)
  • Inventor(s): 山川烈,ジミンレフ、ジミンユラ
  • Industrial Property Rights Holder: 国立大学法人九州工業大学
  • Industrial Property Number: 特許、PCT/ JP2009/ 000639
  • Filing Date: 2009-02-17
  • Overseas