2012 Fiscal Year Final Research Report
Synthetic Studies on Biologically Functional Molecules
| Project/Area Number |
20002004
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| Research Category |
Grant-in-Aid for Specially Promoted Research
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
Chemistry
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| Research Institution | Nagoya University (2012)
The University of Tokyo (2008-2011) |
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Principal Investigator |
FUKUYAMA Tohru 名古屋大学, 大学院・創薬科学研究科, 特任教授 (10272486)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOSHIMA Satoshi 名古屋大学, 大学院・創薬科学研究科, 准教授 (10376593)
SHIMOKAWA Jun 名古屋大学, 大学院・創薬科学研究科, 助教 (60431889)
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| Project Period (FY) |
2008 – 2012
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| Keywords | アルカロイド / 全合成 / 医薬品 / 実用的合成 / 生体機能分子 |
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| Research Abstract |
Aiming for development of efficient synthetic routes toward natural products, which have been used as drugs, or which are expected as drug candidate, we initiated our synthetic programs. As a result, total synthesis of ecteinascidin 743, lysergic acid, huperzine A, salinosporamide and so on have been achieved. Based on the established synthetic routes, a variety of analogs of natural products and related molecules, which includes vinblastine, oseltamivir and so on have been synthesized.
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