2009 Fiscal Year Final Research Report
The functions of autotaxin in the regulation of blood vessel formation
| Project/Area Number |
20013005
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tohoku University |
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Principal Investigator |
AOKI Junken Tohoku University, 大学院・薬学研究科, 教授 (20250219)
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| Project Period (FY) |
2008 – 2009
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| Keywords | オートタキシン / 血管新生 / リゾホスファチジン酸 / ゼブラフィッシュ |
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| Research Abstract |
Recent studies of autotaxin deficient-mice revealed critical roles of autotaxin in blood vessel formation in mice, although the precise effect of autotaxin has been still elsive. In this study we utilized zebrafish to study the physiological roles of autotaxin in vasculogenesis. Significant lysoPLD activity was observed in the zebrafish homologue of autotaxin. We further suppressed the functions of autotaxin in zebrafish embryos by injecting antisense morpholino against autotaxin, and clarified that autotaxin has important roles in the blood vessel formation in zebrafish.
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Research Products
(50 results)
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[Journal Article] Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts.2010
Author(s)
David M, Wannecq E, Descotes F, Jansen S, Deux B, Ribeiro J, Serre CM, Gres S, Bendriss-Vermare N, Bollen M, Saez S, Aoki J, Saulnier-Blache JS, Clezardin P, Peyruchaud O
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Journal Title
Peer Reviewed
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[Journal Article] Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis.2010
Author(s)
Shinkuma S, Akiyama M, Inoue A, Aoki J, Natsuga K, Nomura T, Arita K, Abe R, Ito K, Nakamura H, Ujiie H, Shibaki A, Suga H, Tsunemi Y, Nishie W, Shimizu H.
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Journal Title
Peer Reviewed
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[Journal Article] Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.2009
Author(s)
Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N,Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M,Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Brauer AU, Chun J,Ninnemann O, Schmitz D, Nitsch R.
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Journal Title
Cell 138
Pages: 1222-1235
Peer Reviewed
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[Journal Article] Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta.2009
Author(s)
Iwasawa Y, Fujii T, Nagamatsu T, Kawana K, Okudaira S, Miura S, Matsumoto J, Tomio A, Hyodo H, Yamashita T, Oda K, Kozuma S, Aoki J, Yatomi Y, Taketani Y
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Journal Title
Am J Reprod Immunol. 62
Pages: 90-95
Peer Reviewed
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[Journal Article] Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression.2009
Author(s)
Nouh MA, Wu XX, Okazoe H, Tsunemori H, Haba R, Abou-Zeid AM, Saleem MD, Inui M, Sugimoto M, Aoki J, Kakehi Y
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Journal Title
Cancer Sci. 100
Pages: 1631-1638
Peer Reviewed
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[Journal Article] Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood.2009
Author(s)
Endo T, Kano K, Motoki R, Hama K, Okudaira S, Ishida M, Ogiso H, Tanaka M, Matsuki N, Taguchi R, Kanai M, Shibasaki M, Arai H, Aoki J
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Journal Title
J Biochem. 146
Pages: 283-93
Peer Reviewed
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[Journal Article] Autotaxin enzyme immunoassay in human cerebrospinal fluid samples.2009
Author(s)
Nakamura K, Ohkawa R, Okubo S, Yokota H, Ikeda H, Yatomi Y, Igarashi K, Ide K, Kishimoto T, Masuda A, Yamamoto T, Tsuji S, Saito N, Kurokawa M, Okudaira S, Aoki J
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Journal Title
Clin Chim Act 405
Pages: 160-162
Peer Reviewed
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