Development of an innovative radiotherapy technologies for the improvement of treatment outcomes of intractable cancers.

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20229009
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: HIRAOKA Masahiro Kyoto University, 医学研究科, 教授 (70173218)
• Project Period (FY): 2008 – 2012
• Keywords: 難治がん / 放射線治療学 / 放射線腫瘍学 / 放射線治療物理学

Research Abstract

疾患/患者毎に異なる腫瘍および周辺リスク臓器の呼吸性動態を考慮した新たな四次元放射線治療法の開発を進め、従来法では不可能であった実投与線量分布に基づく新発想のの高精度放射線治療技術を創出する。さらに、開発した治療技術を用いて、現在の治療法では5-30%の治癒率しか期待できない難治がんである肺がん、悪性胸膜中皮腫、膵がん、食道がん等の治療成績の顕著な向上と合併症の軽減を目指す。

Research Products

• [Journal Article] Prognostic factors in stereotacticbody radiotherapy for non-small-celllung cancer. (2011)
  • Author(s): Matsuo Y, Shibuya K, Nagata Y,Takayama K, Norihisa Y, Mizowaki T,Narabayashi M, Sakanaka K, HiraokaM
  • Journal Title: Int J Radiat Oncol BiolPhys 79 Pages: 1104-11
  • Peer Reviewed
• [Journal Article] New algorithm tosimulate organ movement anddeformation for four-dimensional dosecalculation based on athree-dimensional CT and fluoroscopyof the thorax (2009)
  • Author(s): Miyabe Y., Narita Y., Mizowaki T.,Matsuo Y., Takayama K., TakahashiK., Kaneko S., Kawada N., MaruhashiA., Hiraoka M.
  • Journal Title: Med Phys 36 Pages: 4328-4339
  • Peer Reviewed
• [Journal Article] Measurement of InterfractionVariations in Position and Size ofTarget Volumes in Stereotactic BodyRadiotherapy for Lung Cancer (2009)
  • Author(s): Matsugi K., Narita Y., Sawada A.,Nakamura M., Miyabe Y., Matsuo Y.,Narabayashi M., Norihisa Y.,Mizowaki T., Hiraoka M.
  • Journal Title: Int JRadiat Oncol Biol Phys 75 Pages: 543-548
  • Peer Reviewed
• [Journal Article] Interfractional dose variations inintensity-modulated radiotherapy withbreath-hold for pancreatic cancer
  • Author(s): Nakamura M., Shibuya K., NakamuraA., Shiinoki T., Matsuo Y., Nakata M.,Sawada A., Mizowaki T., Hiraoka M.
  • Journal Title: IntJ Radiat Oncol Biol Phys in press
  • Peer Reviewed
• [Journal Article] Inter-fractionalreproducibility in pancreatic positionbased on four-dimensional computedtomography
  • Author(s): Shiinoki T., Shibuya K., Nakamura M.,Nakamura A., Matsuo Y., Nakata M.,Sawada A., Mizowaki T., Itoh A.,Hiraoka M.
  • Journal Title: Int J Radiat Oncol BiolPhys in press
  • Peer Reviewed
• [Presentation] Hiraoka M.Potential Advantages of a NewIrradiation Technique: "ThreedimensionalUnicursal Irradiationwith MHI-TM2000" (2010)
  • Author(s): Mizowaki T., Takayama K, Miyabe Y.,Kaneko S., Kokubo M.
  • Organizer: 52^<nd> ASTROAnnual Meeting Int J Radiat OncolBiol Phys 78 S94
  • Place of Presentation: San Diego(米国)
  • Year and Date: 20101031-20101104
• [Presentation] DailyVerification of Insocenter Alignmentfor a New Image Guided RadiotherapySystem, MHI-TM2000 (2009)
  • Author(s): Sawada A., Kaneko S., Takayama K.,Nagano K., Miyabe Y., Nakamura M.,Narita Y., Kokubo M., Takahashi K.,Mizowaki T., Hiraoka M.
  • Organizer: 51^<st> AAPMAnnual Meeting, Med. Phys. 36, 2586
  • Place of Presentation: Anaheim(米国)
  • Year and Date: 20090726-20090730
• [Book] Shaped BeamRadiosurgery : State of the Art (2011)
  • Author(s): Matsuo Y., Shibuya K., Narabayashi M.,Hiraoka M.
  • Total Pages: 267-78
  • Publisher: Springer