Development of an innovative radiotherapy technologies for the improvement of treatment outcomes of intractable cancers

2012 Fiscal Year Final Research Report

• Project/Area Number: 20229009
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: HIRAOKA Masahiro 京都大学, 医学研究科, 教授 (70173218)
• Co-Investigator(Kenkyū-buntansha): MIZOWAKI Takashi 京都大学, 医学(系)研究科(研究院), 准教授 (90314210) ; SHIBUYA Keiko 山口大学, 医学(系)研究科(研究院), 教授 (50335262) ; MATSUO Yukinori 京都大学, 医学(系)研究科(研究院), 講師 (80456897) ; ITASAKA Satoshi 京都大学, 医学(系)研究科(研究院), 講師 (90378654) ; MONZEN Hajime 京都大学, 医学(系)研究科(研究院), 准教授 (10611593) ; SAWADA Akira 京都医療科学大学, 公私立大学の部局等, 教授 (80543446) ; SENDA Michio 公益財団法人先端医療振興財団, その他部局等, その他 (00216558) ; KOKUBO Masaki 公益財団法人先端医療振興財団, その他部局等, その他 (90283605) ; NARITA Yuichiro 京都大学, 医学(系)研究科(研究院), 講師 (30311385)
• Project Period (FY): 2008 – 2012
• Keywords: 放射線治療 / 難治癌 / トランスレーショナルリサーチ / 4次元線量分布 / 高精度放射線照射

Research Abstract

Deformable image registration software and a system for evaluating 4-dimensional dose distribution were successfully developed. In addition, three-dimensional unicursal irradiation technique was newly developed, and the usefulness of this technique was confirmed in both pancreatic cancer and skull base tumors. Impacts of movement and deformation in the upper abdominal organs on the dose distribution were estimated for pancreatic cancer. Then, IMRT technique under breath-holding was developed, and phase I doseescalation study for pancreatic cancer was initiated. Clinical studies for both malignant pleural mesothelioma and cervical esophageal cancer were also started.

Research Products

• [Journal Article] Accuracy verification of infrared marker-based dynamic tumor-tracking irradiation using the gimbaled x-ray head of the Vero4DRT (MHI-TM2000) (2013)
  • Author(s): Mukumoto N, Nakamura M, Sawada A, Suzuki Y, Takahashi K, Miyabe Y, Kaneko S, Mizowaki T, Kokubo M, Hiraoka M.
  • Journal Title: Med. Phys. Volume: 40(4) Pages: 041706
  • DOI: DOI:10.1118/1.4794506
  • Peer Reviewed
• [Journal Article] Volumetric-modulated arc therapy vs conventional fixed-field intensity-modulated radiotherapy in a whole-ventricular irradiation: A planning comparison study. (2013)
  • Author(s): Sakanaka K, Mizowaki T, Sato S, Ogura K, Hiraoka M
  • Journal Title: Med Dosim Volume: 38(2) Pages: 204-8
  • DOI: DOI:10.1016/j.
  • Peer Reviewed
• [Journal Article] Feasibility evaluation of a new irradiation technique: three-dimensional unicursal irradiation with the Vero4DRT (MHI-TM2000) (2013)
  • Author(s): Mizowaki T, Takayama K, Nagano K, Miyabe Y, Matsuo Y, Kaneko S, Kokubo M, Hiraoka M.
  • Journal Title: J Radiat Res. Volume: 1;54(2) Pages: 330-6
  • DOI: DOI:10.1093/jrr/rrs076.
  • Peer Reviewed
• [Journal Article] Dosimetric evaluation of the impacts of different heterogeneity correction algorithms on target doses in stereotactic body radiation therapy for lung tumors. (2012)
  • Author(s): Narabayashi M, Mizowaki T, Matsuo Y, Nakamura M, Takayama K, Norihisa Y, Sakanaka K, Hiraoka M.
  • Journal Title: J Radiat Res Volume: 53(5) Pages: 777-84
  • DOI: DOI:10.1093/jrr/rrs026
  • Peer Reviewed
• [Journal Article] Outcomes of hypofractionated stereotactic radiotherapy for metastatic brain tumors with high risk factors. (2012)
  • Author(s): Ogura K, Mizowaki T, Ogura M, Sakanaka K, Arakawa Y, Miyamoto S, Hiraoka M.
  • Journal Title: J Neurooncol. Volume: 109(2) Pages: 425-32
  • DOI: DOI:10.1007/s11060-012-0912-6.
  • Peer Reviewed
• [Journal Article] Analysis of dosimetric parameters associated with acute gastrointestinal toxicity and upper gastrointestinal bleeding in locally advanced pancreatic cancer patients treated with gemcitabine-based concurrent chemoradiotherapy. (2012)
  • Author(s): Nakamura A, Shibuya K, Matsuo Y, Nakamura M, Shiinoki T, Mizowaki T, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 84(2) Pages: 369-75
  • DOI: DOI:10.1016/j.ijrobp.2011.12.026
  • Peer Reviewed
• [Journal Article] Interfractional dose variations in intensity-modulated radiotherapy with Breath-hold for pancreatic cancer. (2012)
  • Author(s): Nakamura M, Shibuya K, Nakamura A, Shiinoki T, Matsuo Y, Nakata M, Sawada A, Mizowaki T, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 82(5) Pages: 1619-26
  • DOI: DOI:10.1016/j.ijrobp.2011.01.050
  • Peer Reviewed
• [Journal Article] 腫瘍イメージング剤 :低酸素領域イメージング剤 : FMISO (2012)
  • Author(s): 山根登茂彦、千田道雄
  • Journal Title: PET Journal Volume: 19 Pages: 29-31
  • URL: http://mol.medicalonline.jp/library/journal/download?GoodsID=an5ptjoc/2012/000019/012&name=0029-0031j&UserID=130.54.130.249
• [Journal Article] Dose-volume metrics associated with radiation pneumonitis after stereotactic body radiation therapy for lung cancer. (2012)
  • Author(s): Matsuo Y, Shibuya K, Nakamura M, Narabayashi M, Sakanaka K, Ueki N, Miyagi K, Norihisa Y, Mizowaki T, Nagata Y, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 83(4) Pages: e545-9
  • DOI: DOI:10.1016/j.ijrobp.2012.01.018
  • Peer Reviewed
• [Journal Article] Prognostic factors in stereotactic body radiotherapy for non-small-cell lung cancer. (2011)
  • Author(s): Matsuo Y, Shibuya K, Nagata Y, Takayama K, Norihisa Y, Mizowaki T, Narabayashi M, Sakanaka K, Hiraoka M
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 79(4) Pages: 1104-11
  • DOI: DOI:10.1016/j.ijrobp.2009.12.022
  • Peer Reviewed
• [Journal Article] Interfractional reproducibility in pancreatic position based on four-dimensional computed tomography. (2011)
  • Author(s): Shiinoki T, Shibuya K, Nakamura M, Nakamura A, Matsuo Y, Nakata M, Sawada A, Mizowaki T, Itoh A and Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 80(5) Pages: 1567-1572
  • DOI: DOI:10.1016/j.ijrobp.2010.10.020
  • Peer Reviewed
• [Journal Article] Reduction of [18F]fluoromisonidazole uptake after neoadjuvant chemotherapy for head and neck squamous cell carcinoma. (2011)
  • Author(s): Yamane T, Kikuchi M, Shinohara S, Senda M.
  • Journal Title: Mol Imaging Biol. Volume: 13(2) Pages: 227-31
  • DOI: DOI:10.1007/s11307-010-0365-2.
  • Peer Reviewed
• [Journal Article] 18F-fluoromisonidazole positron emission tomography before treatment is a predictor of radiotherapy outcome and survival prognosis in patients with head and neck squamous cell carcinoma. (2011)
  • Author(s): Kikuchi M, Yamane T, Shinohara S, Fujiwara K, Hori SY, Tona Y, Yamazaki H, Naito Y, Senda M.
  • Journal Title: Ann Nucl Med Volume: 25(9) Pages: 625-33
  • DOI: DOI:10.1007/s12149-011-0508-9.
  • Peer Reviewed
• [Journal Article] Positioning accuracy of a new image-guided radiotherapy system (2011)
  • Author(s): Miyabe Y, Sawada A, Takayama K, Kaneko S, Mizowaki T, Kokubo M, Hiraoka M.
  • Journal Title: Med. Phys. Volume: 38 Pages: 2535-2541
  • DOI: DOI:10.1016/j.ijrobp.2010.05.046.
  • URL: http://online.medphys.org/resource/1/mphya6/v38/i5/p2535_s1
  • Peer Reviewed
• [Journal Article] Characterization of FDG-PET images after stereotactic body radiation therapy for lung cancer (2010)
  • Author(s): Matsuo Y, Nakamoto Y, Nagata Y, Shibuya K, Takayama K, Norihisa Y, Narabayashi M, Mizowaki T, Saga T, Higashi T, Togashi K, Hiraoka M.
  • Journal Title: Radiother Oncol. Volume: 97(2) Pages: 200-4
  • DOI: DOI:10.1016/j.radonc.2010.04.011
  • Peer Reviewed
• [Journal Article] Stereotactic body radiation therapy for lung cancer: achievements and perspectives. (2010)
  • Author(s): Hiraoka M, Matsuo Y, Takayama K.
  • Journal Title: Jpn J Clin Oncol. Volume: 40(9) Pages: 846-54
  • DOI: DOI:10.1093/jjco/hyq134
  • Peer Reviewed
• [Journal Article] Dosimetric characterization of a multi-leaf collimator for a new four-dimensional image-guided radiotherapy system with a gimbaled x-ray head. (2010)
  • Author(s): Nakamura M, Sawada A, Ishihara Y, Takayama K, Mizowaki T, Kaneko S, Yamashita M, Tanabe H, Kokubo M, Hiraoka M.
  • Journal Title: Med Phys. Volume: 37 Pages: 4684-4691
  • URL: http://online.medphys.org/resource/1/mphya6/v37/i9/p4684_s1
  • Peer Reviewed
• [Journal Article] Positional Reproducibility of Pancreatic Tumors Under End-Exhalation Breath-Hold Conditions Using a Visual Feedback Technique (2010)
  • Author(s): Nakamura M, Shibuya K, Shiinoki T, Matsuo Y. Nakamura A, Nakata M, Sawada A, Mizowaki T, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 79 Pages: 1565-1571
  • DOI: DOI: 10.1016/j.ijrobp.2010.05.046.
  • Peer Reviewed
• [Journal Article] Initial and cumulative recurrence patterns of glioblastoma after temozolomide-based chemoradiotherapy and salvage treatment: a retrospective cohort study in a single institution.
  • Author(s): Ogura K, Mizowaki T, Arakawa Y, Ogura M, Sakanaka K, Miyamoto S, and Hiraoka M.
  • Journal Title: Radiat Oncol. Volume: (in press)
  • Peer Reviewed
• [Presentation] Four-dimensional Monte Carlo dose calculation method for dynamic tumor tracking irradiation using Vero4DRT (2013)
  • Author(s): Ishihara Y, et al.
  • Organizer: Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
  • Place of Presentation: Sapporo
  • Year and Date: 20130207-08
• [Presentation] Realization of Dynamic Tumor Tracking Irradiation with Real-time Monitoring in Lung Tumor Patients using a Gimbaled x-ray head Radiation Therapy Equipment. (2012)
  • Author(s): Hiraoka M, et al
  • Organizer: 54th ASTRO's Annual meeting
  • Place of Presentation: Boston(米国)
  • Year and Date: 20121028-31
• [Presentation] Four-dimensional Monte Carlo Dose Calculation Method for Dynamic Tumor Tracking Irradiation with a Gimbaled X-ray Head (2012)
  • Author(s): Ishihara Y, et al.
  • Organizer: 54th ASTRO's Annual meeting
  • Place of Presentation: Boston(米国)
  • Year and Date: 20121028-31
• [Presentation] Dosimetric validation of the algorithm based on linear Boltzmann transport equations for photon 4MV dose calculation (2012)
  • Author(s): Sato S, et al.
  • Organizer: 54th AAPM Annual Meeting
  • Place of Presentation: Charlotte(米国)
  • Year and Date: 20120729-0802
• [Presentation] Image-guided Radiotherapy and Dynamic Tumor Tracking with Real-time Monitoring using Vero4DRT (MHI-TM2000). (2012)
  • Author(s): Matsuo Y.
  • Organizer: In: The 6th S. Takahashi Memorial Symposium and the 6th Japan-US Cancer Therapy International Joint Symposium.
  • Place of Presentation: 広島国際会議場、広島(招待)
  • Year and Date: 20120719-21
• [Presentation] Dosimetric investigation of breath-hold intensity-modulated radiotherapy for pancreatic cancer. (2012)
  • Author(s): Nakamura M, et al.
  • Organizer: World congress Medical Physics and Biomedical Engineering
  • Place of Presentation: Beijing(中国)
  • Year and Date: 20120526-31
• [Presentation] Realization of Dynamic Tumor Tracking Irradiation with Real-time Monitoring in Lung Tumor Patients using a Gimbaled x-ray head Radiation Therapy Equipment. (2012)
  • Author(s): Hiraoka M, et al
  • Organizer: In: ESTRO 31.
  • Place of Presentation: CCIB, Barcelona(スぺインン)(招待)
  • Year and Date: 20120509-13
• [Presentation] An Initial Experience of Dynamic Tumor Tracking Irradiation with Real-time Monitoring using Vero4DRT (MHI-TM2000). (2012)
  • Author(s): Matsuo Y, et al
  • Organizer: In: ESTRO 31.
  • Place of Presentation: CCIB, Barcelona(スぺインン)(招待)
  • Year and Date: 20120509-13
• [Presentation] Dynamic Tumor Tracking with Real-time Monitoring using a Gimbaled Linac of Vero4DRT (MHI-TM2000). (2012)
  • Author(s): Matsuo Y, Hiraoka M
  • Organizer: In: EPI2k12.
  • Place of Presentation: Four Points by Sheraton, Daring Harbour, Sydney(オーストラリア)(招待)
  • Year and Date: 20120312-14
• [Presentation] Dynamic Tumor Tracking Irradiation with Real-time Monitoring using Vero4DRT (MHI-TM2000) (2012)
  • Author(s): Matsuo Y, et al.
  • Organizer: In: The 4th Japan-Korea-China Trilateral Symposium on Radiation Oncology.
  • Place of Presentation: 東京国際フォーラム, 東京
  • Year and Date: 2012-11-23
• [Presentation] Analysis of the prognostic value of 18Fluorodeoxyglucose PET for locally advanced pancreas cancer patients treated with gemcitabine-based chemoradiation therapy. (2011)
  • Author(s): Nakamura A, et al.
  • Organizer: 53rd ASTRO's Annual meeting
  • Place of Presentation: Miami BeachFla(米国)
  • Year and Date: 20111002-06
• [Presentation] Interfractional Dose Variations for Organs at Risk in Intensity Modulated Radiotherapy with Breath-hold for Pancreatic Cancer: Impacts of Margin Sizes for the Dose-limiting Organs. (2010)
  • Author(s): Nakamura A, et al.
  • Organizer: 52nd ASTRO's Annual meeting
  • Place of Presentation: San Diego(米国)
  • Year and Date: 20101031-1104
• [Presentation] Interfractional Dose Variation during Intensity Modulated Radiotherapy with Breath-hold for Pancreatic Cancer. (2010)
  • Author(s): Nakamura M, et al
  • Organizer: 52nd ASTRO's Annual meeting
  • Place of Presentation: San Diego(米国)
  • Year and Date: 20101031-1104
• [Presentation] Stereotactic Body Radiotherapy for Non-Small Cell Lung Cancer:Kyoto University Experience. (2010)
  • Author(s): Matsuo Y, et al.
  • Organizer: 9th International Conference of the Asian Clinical Oncology Society
  • Place of Presentation: Gifu Grand Hotel, Gifu, Japan
  • Year and Date: 20100825-27
• [Presentation] Local recurrence in Long-term Survivors after Stereotactic Body Radiation Therapy for Lung Cancer (2009)
  • Author(s): Matsuo Y, et al.
  • Organizer: 51st ASTRO's Annual meeting
  • Place of Presentation: Chicago(米国)
  • Year and Date: 20091101-05
• [Presentation] Evaluation of Positional Reproducibility for Pancreatic Tumor under Breath-hold Conditions with Visual Coaching. (2009)
  • Author(s): Nakamura M, et al.
  • Organizer: 51st ASTRO's Annual meeting
  • Place of Presentation: Chicago(米国)
  • Year and Date: 20091101-05
• [Presentation] Analysis of dosimetric factors associated with gastrointenstinal and blood toxicity in patients with locally advanced pancreatic cancer treated with concurrent chemoradiation therapy (2009)
  • Author(s): Shibuya K, et al.
  • Organizer: ECOO/ESMO Multidisciplinary congress
  • Place of Presentation: Berlin(ドイツ)
  • Year and Date: 20090920-24
• [Book] Stereotactic Body Radiotherapy for the Lung. In: De Salles AAF, Gorgulho A, Agazaryan N, Slotman B, Selch M, Burwick AJ, Schulz R, eds. Shaped Beam Radiosurgery (2011)
  • Author(s): Matsuo Y, Shibuya K, Narabayashi M, Hiraoka M.
  • Total Pages: 267-277
  • Publisher: Springer Berlin Heidelberg
• [Book] 小細胞肺癌に対する定位放射線治療、Medical Torch;7(1)(金澤右編) (2011)
  • Author(s): 澁谷景子
  • Total Pages: 24-25
  • Publisher: フォレストプリンコム Medical Torch 編集部、東京
• [Book] 臓器別の放射線治療 Q25 膵癌、がん治療レクチャー;2(1)(平岡真寛編) (2011)
  • Author(s): 澁谷景子
  • Total Pages: 133-138
  • Publisher: 総合医学社、東京
• [Book] 切除不能膵癌に対する集学的治療-切除不能膵癌に対する放射線治療、消化器外科(日本消化器外科学会編) (2010)
  • Author(s): 澁谷景子、平岡真寛
  • Total Pages: 1853-1860
  • Publisher: へるす出版、東京