2012 Fiscal Year Final Research Report
Development ofnew nanogel-based drug delivery systems
| Project/Area Number |
20240047
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyoto University (2010-2012)
Tokyo Medical and Dental University (2008-2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Yoshihiro 京都大学, 工学研究科, 准教授 (90314541)
SAWADA Shinichi 京都大学, 工学研究科, 助教 (50444104)
MORITA Ikuo 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (60100129)
MORIMOTO Nobuyuki 東北大学, 工学研究科, 准教授 (00313263)
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| Project Period (FY) |
2008 – 2012
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| Keywords | ナノゲル / ヒドロゲル / タンパク質 / ドラッグデリバリー / 細胞機能 |
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| Research Abstract |
We first reported new method of preparation of physically cross-linked nanogels by self-assembly of hydrophobized polysaccharides. In this project, we develop new polysaccharide nanogels by functional associating polymers and bottom-up nanogel engineering, in which nanogels are used as building blocks to control the nanostructure of macrogels, particles, sheets. Nanogel-based materials with functions of molecular chaperon are useful as protein delivery system and as scaffolds in regenerative medicine such as bone formation.
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