Research on rehabilitation for the osteochondral grafting surgeryand cartilage lesions

2012 Fiscal Year Final Research Report

• Project/Area Number: 20240057
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kyoto University
• Principal Investigator: KUROKI Hiroshi 京都大学, 医学研究科, 教授 (20170110)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Yasuaki 京都医療センター臨床研究センター, 臨床研究企画運営部, 研究員 (90293860) ; KOBAYASHI Masahiko 京都大学, 医学研究科, 講師 (20378623)
• Project Period (FY): 2008 – 2012
• Keywords: 骨軟骨移植 / 関節軟骨 / 軟骨損傷 / リハビリテーション / 超音波

Research Abstract

The major goal of the present study is to indicate evidences on intervention of rehabilitation for the osteochondral grafting surgery and cartilage lesions. We obtained the evidencethat normal knee function was recovered in human subjects at postoperative one year of the osteochondralgrafting surgery and thatnormal findings of cartilage were observed at postoperative oneyear ofthesurgery for rabbits.

Research Products

• [Journal Article] Effects of Exercise Level on Biomarkers ina Rat Knee Model of Osteoarthritis. (2013)
  • Author(s): Yamaguchi S, Aoyama T, Ito A, Nagai M,Iijima H, Zhang X, Tajino J, Kuroki H
  • Journal Title: JOrthop Res.
  • DOI: doi:10.1002/jor.22332.
  • Peer Reviewed
• [Journal Article] Low-intensity pulsedultrasound inhibits messenger RNAexpression of matrix metalloproteinase-13induced by interleukin-1 β inchondrocytes in an intensity-dependentmanner. (2012)
  • Author(s): Ito A, Aoyama T, Yamaguchi S, Zhang X,Akiyama H, Kuroki H.
  • Journal Title: Ultrasound Med Biol. Volume: 38(10) Pages: 1726-33
  • DOI: doi:10.1016/j.ultrasmedbio.2012.06.005
  • Peer Reviewed
• [Journal Article] 低出力超音波パルス療法が関節軟骨代謝に与える即時的影響 異なる刺激強度を用いた研究 (2012)
  • Author(s): 伊藤明良, 青山朋樹, 山口将希, 秋山治彦, 黒木裕士.
  • Journal Title: 理学療法学 Volume: 39(5) Pages: 307-313
  • Peer Reviewed
• [Journal Article] Fiber components ofthe shoulder superior labrum. (2012)
  • Author(s): Arai R, Kobayashi M, Toda Y, Nakamura S,Miura T, Nakamura T.
  • Journal Title: Surg RadiolAnat. Volume: 34(1) Pages: 49-56
  • DOI: doi:10.1007/s00276-011-0840-8
  • Peer Reviewed
• [Journal Article] 解剖学的二重束ACL再建術の短期成績とイメージマッチング法による術前回旋不安定性評価 (2012)
  • Author(s): 小林雅彦、中村伸一郎、新井隆三、浅野太洋、中川泰彰、中村孝志
  • Journal Title: 整スポ会誌 Volume: 32巻2号 Pages: 119-123
  • Peer Reviewed
• [Journal Article] Longitudinal evaluation ofcartilage after osteochondral autogenoustransfer with delayed gadolinium-enhancedMRI of the cartilage (dGEMRIC). (2012)
  • Author(s): Shirai T, Kobayashi M, Nakamura S, AraiR, Nishitani K, Satake T, Dahlberg LE,Kuroki H, Nakagawa Y, Okada T, Togashi K,Nakamura T.
  • Journal Title: J OrthopRes. Volume: 30(2) Pages: 221-5
  • DOI: doi:10.1002/jor.21514.
  • Peer Reviewed
• [Journal Article] Image-matchingtechnique can detect rotational and APinstabilities in chronic ACL-deficientknees. (2011)
  • Author(s): Nakamura S, Kobayashi M, Asano T, AraiR, Nakagawa Y, Nakamura T.
  • Journal Title: Knee Surg Sports Traumatol Arthrosc Volume: 19 Suppl 1 Pages: 69-76
  • Peer Reviewed
• [Journal Article] Chondroprotective effect ofalendronate in a rabbit model ofosteoarthritis. (2011)
  • Author(s): Shirai T, Kobayashi M, Nishitani K,Satake T, Kuroki H, Nakagawa Y, NakamuraT.
  • Journal Title: J Orthop Res. Volume: 29(10) Pages: 1572-7
  • DOI: doi:10.1002/jor.21394.Epub2011Apr1.
  • Peer Reviewed
• [Journal Article] Care should especially be taken concerningknee joint angle and the contact area inrehabilitation planned followingautologous osteochondral grafting forknee cartilage lesions: A report of twocases. (2011)
  • Author(s): Hiroshi Kuroki, Toru Oka, Taizo Furukawa,Masahiko Kobayashi, Yasuaki Nakagawa.
  • Journal Title: ICRS Newsletter Volume: Winter Issue 14 Pages: 41-42
  • Peer Reviewed
• [Journal Article] Fluoroscopic and computed tomographicanalysis of knee kinematics during verydeep flexion after total knee arthroplasty (2010)
  • Author(s): Nakamura S, Takagi H, Asano T, NakagawaY, Kobayashi M, and Nakamura T.
  • Journal Title: J Arthroplasty Volume: 25:3 Pages: 486-491
  • Peer Reviewed
• [Journal Article] The Bi-Surface totalknee arthroplasty: minimum 10-yearfollow-up study. (2010)
  • Author(s): Nakamura S, Kobayashi M, Ito H, NakamuraK, Ueo T, Nakamura T.
  • Journal Title: Knee. Volume: 17(4) Pages: 274-8
  • Peer Reviewed
• [Journal Article] Structural damageand chemical contaminants on reprocessedarthroscopic shaver blades (2009)
  • Author(s): Kobayashi M, Nakagawa Y, Okamoto Y,Nakamura S, Nakamura T.
  • Journal Title: Am J SportsMed Volume: 37(2) Pages: 266-73
  • Peer Reviewed
• [Journal Article] Ultrasound has thepotential to detect degeneration ofarticular cartilage clinically, even ifthe information is obtained from anindirect measurement of intrinsicphysical characteristics. (2009)
  • Author(s): Kuroki H, Nakagawa Y, Mori K, KobayashiM, Yasura K, Okamoto Y, Suzuki T, NishitaniK, Nakamura T.
  • Journal Title: Arthritis ResTher Volume: 11(3) Pages: 408
  • Peer Reviewed
• [Journal Article] Ultrasound properties ofarticular cartilage immediately afterosteochondral grafting surgery: in casesof traumatic cartilage lesions andosteonecrosis. (2009)
  • Author(s): Kuroki H, Nakagawa Y, Mori K, KobayashiM, Nakamura S, Nishitani K, Shirai T,Nakamura T.
  • Journal Title: Knee Surg Sports TraumatolArthrosc Volume: 17(1) Pages: 11-8
  • Peer Reviewed
• [Journal Article] Positive effect of Alendronate onsubchondral bone healing and subsequentcartilage repair in a rabbit osteochondraldefect model. (2009)
  • Author(s): Nishitani K, Shirai T, Kobayashi M,Kuroki H, Azuma Y, Nakagawa Y, Nakamura T.
  • Journal Title: Am J Sports Med Volume: 37(Suppl 1) Pages: 139S-47S
  • Peer Reviewed
• [Journal Article] 距骨骨軟骨障害(OLT)に対する骨軟骨移植術(OAT) (2009)
  • Author(s): 小林与人、小林雅彦、中村伸一郎、中川泰彰、中村孝志
  • Journal Title: 中部整災誌 Volume: 52 Pages: 1019-1020
  • Peer Reviewed
• [Journal Article] Ultrasound properties ofarticular cartilage immediately afterosteochondral grafting surgery: in casesof traumatic cartilage lesions andosteonecrosis. (2009)
  • Author(s): Kuroki H, Nakagawa Y, Mori K, KobayashiM, Nakamura S, Nishitani K, Shirai T,Nakamura T.
  • Journal Title: Knee Surg Sports TraumatolArthrosc. Volume: 17(1) Pages: 11-8
  • Peer Reviewed
• [Journal Article] Ultrasound propertiesof articular cartilage immediately afterosteochondral grafting surgery: in casesof traumatic cartilage lesions andosteonecrosis. (2009)
  • Author(s): Hiroshi Kuroki, Yasuaki Nakagawa, KojiMori, Masahiko Kobayashi, ShinichiroNakamura, Kohei Nishitani, Takaaki Shirai,Takashi Nakamura
  • Journal Title: Knee Surgery, SportsTraumatology, Arthroscopy Volume: 17(1) Pages: 11-18
  • Peer Reviewed
• [Journal Article] Positive effect of alendronate onsubchondral bone healing and subsequentcartilage repair in a rabbit osteochondraldefect model. (2009)
  • Author(s): Nishitani K, Shirai T, Kobayashi M,Kuroki H, Azuma Y, Nakagawa Y, Nakamura T
  • Journal Title: American Journal of SportsMedicine Volume: 37(Suppl.1) Pages: 139S-147S
  • Peer Reviewed
• [Journal Article] 反復性膝蓋骨脱臼に対する内側膝蓋大腿靱帯再建術後の理学療法の経験 筋力強化運動とROM運動についての検討 (2009)
  • Author(s): 岡 徹, 黒木裕士, 水野泰行, 古川泰三
  • Journal Title: 理学療法ジャーナル Volume: 43(12) Pages: 1067-1071
  • Peer Reviewed
• [Journal Article] 少年野球選手に対するメディカルチェックを実施して (2009)
  • Author(s): 岡 徹,黒木裕士, 秋山奈菜子, 長谷川聡, 古川泰三, 水野泰行
  • Journal Title: スポーツ障害の予防と啓蒙活動.理学療法京都 Volume: 38 Pages: 66-67
  • Peer Reviewed
• [Journal Article] 膝離断性骨軟骨炎に対する骨軟骨移植術後の膝機能とリハビリテーション4症例の短期経過. (2009)
  • Author(s): 岡 徹, 黒木裕士, 水野泰行, 古川泰三, 中川泰彰
  • Journal Title: 膝 Volume: 33(1) Pages: 74-78
  • Peer Reviewed
• [Journal Article] Ultrasound properties ofarticular cartilage in the tibio-femoral joint in knee osteoarthritis: relation toclinical assessment (InternationalCartilage Repair Society grade) (2008)
  • Author(s): Kuroki H, Nakagawa Y, Mori K, KobayashiM, Yasura K, Okamoto Y, Suzuki T, NishitaniK, Nakamura T
  • Journal Title: Arthritis Res Ther. Volume: 10(4) Pages: R78
  • Peer Reviewed
• [Journal Article] 下肢の日帰り手術 (2008)
  • Author(s): 中川泰彰、小林雅彦、中村伸一郎、中村孝志
  • Journal Title: 整形外科最小侵襲手術ジャーナル Volume: 47 Pages: 49-54
  • Peer Reviewed
• [Journal Article] Ultrasound properties of articularcartilage in knee osteoarthritis:relation to clinical assessment (International Cartilage Repair Societygrade). (2008)
  • Author(s): Hiroshi Kuroki, Yasuaki Nakagawa, KojiMori, Masahiko Kobayashi, Ko Yasura,Yukihiro Okamoto, Takashi Suzuki, KoheiNishitani and Takashi Nakamura.
  • Journal Title: Arthritis Research & Therapy Volume: 10 Pages: R78
  • Peer Reviewed
• [Journal Article] 遠位上腕二頭筋腱断裂術後の早期理学療法の経験. (2008)
  • Author(s): 岡 徹,黒木裕士,古川泰三,水野泰行
  • Journal Title: 理学療法ジャーナル Volume: 42(10) Pages: 895-898
  • Peer Reviewed
• [Journal Article] 膝関節骨・軟骨疾患に対する骨軟骨移植術(モザイクプラスティ)後の機能回復経過 ～40歳未満群と40歳以上群の比較～ (2008)
  • Author(s): 岡 徹,黒木裕士,水野泰行,古川泰三,中川泰彰
  • Journal Title: 運動療法と物理療法 Volume: 19(1) Pages: 50-5
  • Peer Reviewed
• [Journal Article] 膝離断性骨軟骨炎に対する骨軟骨移植術後の膝機能とリハビリテーション～4 症例の短期経過～ (2008)
  • Author(s): 岡 徹,黒木裕士,水野泰行,古川泰三,中川泰彰
  • Journal Title: 膝 Volume: 33(1) Pages: 74-78
  • Peer Reviewed
• [Journal Article] Intraoperativeacoustic evaluation of living humancartilage of the elbow and knee duringmosaicplasty for osteochondritisdissecans of the elbow.
  • Author(s): Nishitani K, Nakagawa Y, Mori K,Kobayashi M, Nakamura T.
  • Journal Title: Am J Sports Med Volume: 36(12) Pages: 2345-53
  • Peer Reviewed
• [Presentation] Culturing temperature affectschondrocyte differentiation andextracellular matrix formation. (2013)
  • Author(s): Ito A, Aoyama T, Tajino J, Nagai M,Yamaguchi S, Iijima H, Zhang X, Akiyama H,Kuroki H.
  • Organizer: OARSI 2013
  • Place of Presentation: MarriottPhiladelphia Downtown, Philadelphia, USA
  • Year and Date: 20130418-23
• [Presentation] Is cartilage andsubchondral bone covered by menisci weak (2013)
  • Author(s): Iijima H, Aoyama T, Ito A, Tajino J,Nagai M, Ito A, Zhang X, Yamaguchi S,Akiyama H, Kuroki H.
  • Organizer: OARSI 2013
  • Place of Presentation: MarriottPhiladelphia Downtown, Philadelphia, USA
  • Year and Date: 20130418-23
• [Presentation] Changes on the expression of CD44 inimmobilized knee in rats (2013)
  • Author(s): Nagai M, Ito A, Zhang X, Yamaguchi S,Iijima H, Tajino J, Aoyama T, Kuroki H.
  • Organizer: OARSI 2013
  • Place of Presentation: MarriottPhiladelphia Downtown, Philadelphia, USA
  • Year and Date: 20130418-23
• [Presentation] 半月板被覆部軟骨は脆弱であるのか (2013)
  • Author(s): 飯島弘貴,青山朋樹,伊藤明良,太治野純一,長井桃子,張 項凱,山口将希,秋山治彦,黒木裕士
  • Organizer: 第26回日本軟骨代謝学会
  • Place of Presentation: 千里ライフサイエンスセンター
  • Year and Date: 20130301-02
• [Presentation] 温度環境が軟骨細胞外基質形成に与える影響 (2013)
  • Author(s): 伊藤明良,青山朋樹,長井桃子,山口将希,飯島弘貴,張 項凱,太治野純一,秋山治彦,黒木裕士
  • Organizer: 第26回日本軟骨代謝学会
  • Place of Presentation: 千里ライフサイエンスセンター
  • Year and Date: 20130301-02
• [Presentation] 初期変形性膝関節症に対する骨軟骨移植術後の再鏡視像 (2012)
  • Author(s): 小林雅彦、新井隆三、原田豪人、築山浩之、中川泰彰
  • Organizer: 第4回日本関節鏡・膝・スポーツ整形外科学会(JOSKAS)
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 20120719-21
• [Presentation] ステロイド性骨壊死に対する自家骨軟骨移植術後の再鏡視所見. 第4回日本関節鏡・膝・スポーツ整形外科学会(JOSKAS) (2012)
  • Author(s): 築山浩之、小林雅彦、新井隆三、原田豪人
  • Organizer: 第4回日本関節鏡・膝・スポーツ整形外科学会(JOSKAS)
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 20120719-21
• [Presentation] Functionalrecovery after autologous osteochondraltransplantation (mosaicplasty). (2012)
  • Author(s): H. Kuroki, T. Oka, T. Furukawa, M.Kobayashi, Y. Nakagawa.
  • Organizer: The 18thEuropean Congress of Physical &Rehabilitation Medicine
  • Place of Presentation: Thessaloniki, Greece.
  • Year and Date: 20120528-0601
• [Presentation] 低出力超音波パルスは強度依存性に軟骨破壊因子を抑制する (2012)
  • Author(s): 伊藤明良,山口将希,張項凱,黒木裕士
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 20120525-27
• [Presentation] ACLT モデルラットに対する運動負荷が関節軟骨に及ぼす影響 (2012)
  • Author(s): 山口将希,黒木裕士,伊藤明良,張項凱
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 20120525-27
• [Presentation] LOW-INTENSITY PULSEDULTRASOUND INHIBITS MESSENGER RNAEXPRESSION OF MATRIX METALLOPROTEINASE-13IN RAT CHONDROCYTES. (2012)
  • Author(s): Kuroki H, Ito A, Zhang X, Yamaguchi S,Aoyama T, Akiyama H
  • Organizer: EUROSON 2012
  • Place of Presentation: Madrid, Spain
  • Year and Date: 20120422-24
• [Presentation] Low-intensity pulsed ultrasoundinhibits messenger RNA expression of MMP13induced by interleukin-1β inintensity-dependent manner onchondrocytes. (2012)
  • Author(s): Akira Ito, Xiang Kai Zhang, SyokiYamaguchi, Haruhiko Akiyama, Hiroshi Kuroki
  • Organizer: EUROSON 2012
  • Place of Presentation: Madrid, Spain
  • Year and Date: 20120422-24
• [Presentation] Chondroprotectiveeffect of Alendronate in a rabbit model ofosteoarthritis. (2012)
  • Author(s): T. Shirai, M. Kobayashi, K. Nishitani,T. Satake, H. Kuroki, Y. Nakagawa, C.Tanaka, T. Nakamura.
  • Organizer: EUROSON 2012
  • Place of Presentation: Madrid, Spain
  • Year and Date: 20120422-24
• [Presentation] 初期変形性膝関節症に対する骨軟骨移植術 (2012)
  • Author(s): 小林雅彦、原田豪人、築山浩之、中川泰彰
  • Organizer: 第118回中部日本整形外科災害外科学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 20120406-07
• [Presentation] 初期変形性膝関節症患者に対する機能的電気刺激トレーニングの効果 (2012)
  • Author(s): 小林 雅彦、長谷川 聡、原田豪人、築山浩之
  • Organizer: 第118回中部日本整形外科災害外科学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 20120406-07
• [Presentation] 膝前十字靭帯再再建術症例の検討 (2012)
  • Author(s): 築山浩之, 小林雅彦, 原田豪人 水野泰行 岩城公一
  • Organizer: 第118回中部日本整形外科災害外科学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 20120406-07
• [Presentation] IL-1βにより惹起されたMMP13mRNA発現亢進に対する低出力超音波パルスの即時的効果. (2012)
  • Author(s): 伊藤明良,山口将希,張 項凱,青山朋樹,秋山治彦,黒木裕士
  • Organizer: 第25回日本軟骨代謝学会
  • Place of Presentation: ウィルあいち
  • Year and Date: 20120309-10
• [Presentation] Optical coherence tomographyによる家兎自家骨軟骨柱移植術モデルの評価 (2012)
  • Author(s): 佐竹剛,小林雅彦,原田豪人,新井隆三,黒木裕士
  • Organizer: 第25回日本軟骨代謝学会
  • Place of Presentation: ウィルあいち
  • Year and Date: 20120309-10
• [Presentation] Low-intensitypulsed ultrasound downregulates themessenger RNA expression of the matrixmetalloproteinases on an articularcartilage explants model. (2011)
  • Author(s): Akira Ito, Tomoki Aoyama, Hiroto Mitsui,Makoto Ishibashi, Shoki Yamaguchi, XiangKai Zhang, Hiroshi Kuroki.
  • Organizer: The 2011 WorldCongress on Osteoarthritis
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-09-16
• [Presentation] ANALYSIS OFMENISCUS USING FOURIER TRANSFORM INFRAREDIMAGING SPECTROSCOPY. (2011)
  • Author(s): Hiroshi Kuroki, Koji Tsuchimoto, MikikoKobayashi-Miura, Tomoki Aoyama, Akira Ito,Kojiro Hashimoto, Makoto Ishibashi, ShokiYamaguchi, Xiang Kai Zhang.
  • Organizer: The 2011 WorldCongress on Osteoarthritis
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-09-16
• [Remarks]
  • URL: http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/pt0102/