2012 Fiscal Year Final Research Report
Molecular mechanism of bacterial signal transduction
| Project/Area Number |
20248012
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2012
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| Keywords | two-component system / SafA / EvgS/EvgA / PhoQ/PhoP / connector |
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| Research Abstract |
Bacteria have evolved two-component signal transduction systems (TCS), which are comprisedof sensor histidine kinases(HK) and theircognate response regulators(RR, transcriptional factor). Bacterial cells have a number of TCSs to respond to various environmental stresses. Comprehensive transcriptome studies of these TCSs suggest that they interact with each other by means of a signal transduction network. In Escherichia colicells, we haveclarified the molecular mechanism of how EvgS/EvgA TCS connects to PhoQ/PhoP TCS via a connector SafA.
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Research Products
(40 results)
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[Journal Article] Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp.2013
Author(s)
Igarashi M, Watanabe T, Hashida T, Umekita M, Hatano M, Yanagita Y, Kino H, Kimura T, Kinoshita N, Inouye K, Sawa R, Nishimura Y,Utsumi R, and Nomoto A
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Journal Title
MK844-mF10.
Volume: (in press)
Peer Reviewed
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[Journal Article] Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalK.2012
Author(s)
Watanabe T, Igarashi M, Okajima T, Ishii E, Kino H, Hatano, M, Sawa R, Umekita M, Kimura T, Okamoto S, Eguchi Y, Akamatsu Y, and Utsumi R
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Journal Title
An timicrob Agen ts Ch emoth er
Volume: 56
Pages: 3657-3663
DOI
Peer Reviewed
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[Journal Article] Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.2010
Author(s)
Okada A, lgarashi M, Okajima T, Kinoshita N, Umekita M, Sawa R, Inoue K, Watanabe T, Doi A, Martin A, Quinn J, Nishimura Y, and Utsumi R
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Journal Title
JAntibiot (Tokyo)
Volume: 63
Pages: 89-94
DOI
Peer Reviewed
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[Journal Article] Novel antibacterial compounds specifically targeting the essential WalR response regulator2010
Author(s)
Gotoh Y, Doi A, Furuta E, Dubrac S, Ishizaki Y, Okada M, Igarashi M, Misawa N, Yoshikawa H, Okajima T, Msadek T, and Utsumi R
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Journal Title
J An tibiot (Tokyo)
Volume: 63
Pages: 127-134
DOI
Peer Reviewed
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[Remarks] Bio-protocol(実験手法データベース)
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[Remarks] Protein-peptide Interaction by Surface Plasmon Resonance (2013)
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[Remarks] Eiji Ishii, Yoko Eguchi and Ryutaro Utsumi
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