2011 Fiscal Year Final Research Report
Total Control of Psycho-immune-endocrine system ; revealing stress specific cytokine cascade
| Project/Area Number |
20249042
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Osaka City University (2010-2011)
Hyogo College of Medicine (2008-2009) |
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Principal Investigator |
SEKIYAMA Atsuo 大阪市立大学, 大学院・医学研究科, 特任准教授 (30403702)
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| Co-Investigator(Kenkyū-buntansha) |
KASAHARA Emiko 大阪市立大学, 大学院・医学研究科, 特任講師 (30468269)
CHIDA Dai 国立国際医療センター(研究所), 臨床病理部, 組織形態室室長 (90312842)
OKAMURA Haruki 兵庫医科大学, 医学部, 教授 (60111043)
UCHIMURA Kenji 名古屋大学, 大学院・医学研究科生物化学講座・分子生物学分野, 特任講師 (20450835)
INOUE Masayasu 大阪市立大学, 大学院・医学研究科, 教授 (80040278)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 心身相関 / ストレス / 免疫学 / サイトカイン / うつ病 / 視床下部下垂体副腎軸 / 脳・神経 / 再生医学 |
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| Research Abstract |
In this study, we have revealed (1) human serological marker to objectify what and how much stress is loaded, (2) a pathway for cytokine induction via interleukin(IL) 18, superoxide, and tumor-necrotizing-factor, (3) a pathway for cytokine induction involving mitochondria, (4) a human serological marker that associates with severity of major depressive disease, and (5) a human serological marker that predicts psycho-behavioral disorders after stress. We have reported these results in several academic meeting including plenary lectures. At the same time, our developed technique to objectify post-stress depression have been practically utilized for people participated to rescue operation of the Tohoku Earthquake.
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[Journal Article] Physiological stress exacerbates murine colitis by enhancing proinflammatory cytokine expression that is dependent on IL-182011
Author(s)
Matsunaga H, Hokari R, Ueda T, Kurihara C, Hozumi H, Higashiyama M, Okada Y, Watanabe C, Komoto S, Nakamura M, Kawaguchi A, Nagao S, Sekiyama A, Miura S
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Journal Title
Am J Physiol Gastrointest Liver Physiol
Volume: 301(3)
Pages: G555-64
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[Presentation] Visualizing Mental Disorders ; distinct plasma levels of cytokines and chemokines in schizophrenia and major depressive disorders2009
Author(s)
Sekiyama A., Sekiyama R., Kasahara E., Shimokata H., Sekiyama K., Inoue M., Tabira T., Okamura H
Organizer
Days of Molecular Medicine, Cognitive Dysfunction in Disease
Place of Presentation
Mechanisms and Therapies, Stockholm, Sweden
Year and Date
2009-04-18
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