2010 Fiscal Year Final Research Report
Study on the pathogenesis of acute encephalitis and encephalopathy for the effective treatment and prevention
| Project/Area Number |
20249053
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Okayama University |
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Principal Investigator |
MORISHIMA Tsuneo Okayama University, 大学院・医歯薬学総合研究科, 教授 (90157892)
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| Co-Investigator(Kenkyū-buntansha) |
OKABE Nobuhiko 国立感染症研究所, 感染症情報センター, センター長 (10057028)
NAKAGOMI Osamu 長崎大学, 大学院・医歯薬学総合研究科, 教授 (70143047)
NUNOI Hiroyuki 宮崎大学, 医学部, 教授 (50218260)
KONDOU Kazuhiro 東京慈恵会医科大学, 医学部, 教授 (70234929)
HOSOYA Mitsuaki 福井県立医科大学, 医学部, 教授 (80192318)
MATSUKAWA Akihiro 岡山大学, 大学院・医歯薬学総合研究科, 教授 (90264283)
KIMURA Hioroshi 名古屋大学, 大学院・医学系研究科, 准教授 (30303621)
YOSHIKAWA Tetsushi 藤田保健衛生大学, 医学部, 准教授 (80288472)
ICHIYAMA Takashi 山口大学, 大学院・医学系研究科, 教授 (20263767)
OKUMURA Akihisa 順天堂大学, 医学部, 准教授 (60303624)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 急性脳症 / 小児感染症学 |
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| Research Abstract |
We have studied on the clinical features and pathogenesis of acute encephalitis/encephalopathy caused by viruses among children. As an causative agent, Influenza virus was a most common virus, followed by HHV-6 and rotavirus, and overall mortality was 7.7%. In terms of the pathogenesis of CNS damage caused by HHV-6 primary infection (E. subitum), virus growth has not been found in the brain tissue, showing encephalopathy not encephalitis. For treatment of this illness, TRX could be an important target in the near future.
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[Journal Article] Differences of clinical manifestations according to the patterns of brain lesions in acute encephalopathy with reduced diffusion in the bilateral hemispheres.2009
Author(s)
Okumura A, Kidokoro H, Tsuji T, Suzuki M, Kubota T, Kato T, Komatsu M, Shono T, Hayakawa F, Shimizu T, Morishima T.
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Journal Title
Am J Neuroradiol 30
Pages: 825-830
Peer Reviewed
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[Journal Article] Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin.2009
Author(s)
Okumura A, Mizuguchi M, Kidokoro H, Tanaka M, Abe S, Hosoya M, Aiba H, Maegaki Y, Yamamoto H, Tanabe T, Noda E, Imataka G, Kurahashi H.
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Journal Title
Brain Dev 31
Pages: 221-227
Peer Reviewed
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[Journal Article] Subacute encephalopathy : Clinical features, laboratory data, neuroimaging, and outcomes.2008
Author(s)
Okumura A, Kidokoro H, Itomi K, Maruyama K, Kubota T, Kondo Y, Itomi S, Uemura N, Natsume J, Watanabe K, Morishima T.
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Journal Title
Pediatr Neurol 38
Pages: 111-117
Peer Reviewed
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