2011 Fiscal Year Final Research Report
Investigation into malignant transformation of endometriosis. prospective cohort study and molecular biology research
| Project/Area Number |
20249066
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Tasuku 鳥取大学, 医学部, 教授 (40218649)
ITAMOCHI Hiroaki 鳥取大学, 医学部, 講師 (20314601)
TANIGUCHI Fuminori 鳥取大学, 医学部附属病院, 講師 (40322218)
HAYASHI Kunihiko 群馬大学, 医学部, 教授 (80282408)
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Hiroshi 奈良県立医科大学, 医学部, 教授 (40178330)
MOMOEDA Mikio 聖路加国際病院, 女性総合診療部, 部長 (50221627)
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| Project Period (FY) |
2008 – 2011
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| Keywords | JEMS / 子宮内膜症 / がん化 / 疫学研究 |
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| Research Abstract |
This project is the prospective study "Investigation for malignant transformation of endometriosis in Japan". We have analyzed the personal data collected from approximately 2, 000 patients diagnosed as endometriosis. Of these patients, seven patients who have had ovarian cancer derived from endometrioma until 2011, and this research work will be conducted for next 10 years. In the basic molecular experiments, only the epithelial cells derived from ovarian endometrioma and clear cell carcinoma of ovary were captured, and analyzed gene expression profile by using the comprehensive cDNA microarray. We assessed the expression and function of fibroblast growth factor receptor(FGFR)-2 associated with the malignant transformation of endometrioma.
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