2010 Fiscal Year Final Research Report
The Mechanism Underlying the Formation of Activity-Dependent Thalamocortical Projection
| Project/Area Number |
20300110
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAMOTO Nobuhiko Osaka University, 大学院・生命機能研究科, 教授 (00191429)
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| Co-Investigator(Kenkyū-buntansha) |
SUGO Noriyuki 大阪大学, 大学院・生命機能研究科, 助教 (20372625)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 軸索分岐 / 軸索誘導 / 神経活動 / 層特異性 / 視床 / 大脳 |
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| Research Abstract |
Neural activity is well known to play an important role in neural circuit formation. However, the mechanism is largely unknown. We studied the role of neural activity in axonal branch formation, focusing on the thalamocortical projection in the mammalian brain. The result shows that both activities of growing thalamic axons (presynaptic) and their target cortical neurons (postsynaptic) promote axon branching. Evidence also suggests the underlying molecular mechanisms.
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