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2010 Fiscal Year Final Research Report

Studies of formation and function of neuronal circuits using alpha-chimerin mutant mice

Research Project

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Project/Area Number 20300118
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionNational Institute of Genetics

Principal Investigator

IWASATO Takuji  国立遺伝学研究所, 個体遺伝研究系, 教授 (00311332)

Co-Investigator(Renkei-kenkyūsha) ITOHARA Shigeyoshi  独立行政法人理化学研究所, 行動遺伝学技術開発チーム, シニアチームリーダー (60252524)
KATOH Hironori  京都大学, 生命科学研究科, 准教授 (50303847)
NISHIMARU Hiroshi  筑波大学, 大学院・人間総合科学研究科, 准教授 (20302408)
Project Period (FY) 2008 – 2010
Keywords神経科学 / マウス / 遺伝学 / 神経回路 / 発達
Research Abstract

We aim to reveal roles of alpha-chimerin Rac-GTPase activating protein(GAP) in formation and function of neuronal circuit in the mammalian brain. We generated global and Cre-mediated conditional knockout mice of alpha-chimerin. Furthermore, we generated knockout mouse lines specific to alpha1 and alpha2 isoforms. By analyzing these mice behaviorally and histologically, we found important roles of alpha-chimerin in hippocampus function.

  • Research Products

    (18 results)

All 2011 2010 2009 2008 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (8 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Role of adenylate cyclase 1 in retinofugal map development2011

    • Author(s)
      Dande, OS., Bhatt, S., Anishchenko, A, Elstrott, J., Iwasato, T., Swindell, EC, Xu, HP., Jamrich, M., Itohara, S., Feller, MB, Crair, MC.
    • Journal Title

      J. Comp. Neurol

    • DOI

      doi:10.1002/cne.23000

    • Peer Reviewed
  • [Journal Article] Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain2010

    • Author(s)
      Tanabe, Y., Hirano, A., Iwasato, T., Itohara, S., et al.
    • Journal Title

      J. Neurochem

      Volume: 112巻 Pages: 1035-1044

    • Peer Reviewed
  • [Journal Article] 中枢神経回路の活動依存的精緻化-マウス体性感覚野に「バレル」が形成される仕組み2009

    • Author(s)
      岩里琢治
    • Journal Title

      生物の科学「遺伝」

      Volume: 63巻 Pages: 79-85

  • [Journal Article] Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter2009

    • Author(s)
      Singer, P., Yee, BK., Feldon, J., Iwasato, T., Itohara, S., et al.
    • Journal Title

      Neuroscience

      Volume: 161巻 Pages: 635-654

    • Peer Reviewed
  • [Journal Article] Beta2-chimaerin binds to EphA receptors and regulates cell migration2009

    • Author(s)
      Takeuchi, S., Yamaki, N., Iwasato, T., Negishi, M., Katoh, H.
    • Journal Title

      FEBS Lett

      Volume: 583巻 Pages: 1237-1242

    • Peer Reviewed
  • [Journal Article] Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layerIVbarrel development2008

    • Author(s)
      Iwasato, T., Inan, M., Kanki, H., Erzurumlu, RS., Itohara, S., et al.
    • Journal Title

      J. Neurosci

      Volume: 28巻 Pages: 5931-5943

    • Peer Reviewed
  • [Journal Article] BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier2008

    • Author(s)
      Araya, R., Kubo, M., Ishii, K., Hashikawa, T., Iwasato, T., Itohara, S., Terasaki, T., Oohira, A., Mishina, Y., Yamada, M.
    • Journal Title

      Mol. Cell Neurosci

      Volume: 38巻 Pages: 417-430

    • Peer Reviewed
  • [Presentation] Loss of Rac-GAP a-chimerin leads to alterations of emotional and cognitive behaviors in mice2011

    • Author(s)
      Iwata, R., Goto, H., Tanaka, M., Itohara, S., Iwasato, T.
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington, DC
    • Year and Date
      20111112-26
  • [Presentation] Loss of Rac-GAP a-chimerin leads to alterations of emotional and cognitive behaviors in mice2011

    • Author(s)
      Iwata, R., Goto, H., Tanaka, M., Itohara, S., Iwasato, T.
    • Organizer
      Molecular and cellular cognition society
    • Place of Presentation
      Washington, DC
    • Year and Date
      20111110-11
  • [Presentation] Rac GAP a-キメリン欠損マウスの網羅的行動解析Comprehensive behavioral analysis of Rac-GAP a-chimaerin deficient mice2011

    • Author(s)
      岩田亮平.後藤大道.田中三佳.糸原重美
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      20110914-17
  • [Presentation] Circuit refinement during postnatal development of the mouse somatosensory cortex2010

    • Author(s)
      岩里琢治
    • Organizer
      BMB2010第33回日本分子生物学会年会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-12-07
  • [Presentation] Comprehensive behavioral analysis of miffy mice, a spontaneous mutant of Rac-GAPα-chimerin2010

    • Author(s)
      Iwata, R., Goto, H., Tanaka, M., Itohara, S., Iwasato, T.
    • Organizer
      Molecular and Cellular Cognition Society-Society for Neuroscience Satellite Symposium 2010
    • Place of Presentation
      San Diego Convention Center(アメリカ合衆国サンディエゴ)
    • Year and Date
      2010-11-11
  • [Presentation] 左右の手足の非対象な動きを可能にする神経回路形成の分子機構2008

    • Author(s)
      岩里琢治
    • Organizer
      BMB2008第31回日本分子生物学会年会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2008-12-12
  • [Presentation] Dissociation of pre-and postsynaptic mechanisms in maturation of the barrel cortex2008

    • Author(s)
      Iwasato, T.
    • Organizer
      The 6th FENS forum of European Neuroscience
    • Place of Presentation
      Geneva
    • Year and Date
      2008-07-15
  • [Presentation] Dissociation of pre-and postsynaptic mechanisms of barrel cortex development2008

    • Author(s)
      岩里琢治
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
  • [Book] Miffy変異マウス:ウサギのように両足をそろえて歩く自然発生変異マウス(分担執筆)<seriesモデル動物利用マニュアル>疾患モデルの作製と利用-脳・神経疾患(三品昌美編)2011

    • Author(s)
      岩里琢治,糸原重美
    • Total Pages
      99-110
  • [Remarks]

    • URL

      http://www.nig.ac.jp/section/iwasato/iwasato-j.html

  • [Remarks]

    • URL

      http://homepage3.nifty.com/iwasato/

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Published: 2013-07-31  

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