2010 Fiscal Year Final Research Report
Identification of novel DOPA ligands and electrophysiological analysis of DOPA-induced response
| Project/Area Number |
20300132
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Yokohama City University |
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Principal Investigator |
GOSHIMA Yoshio Yokohama City University, 医学研究科, 教授 (00153750)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Takuya 横浜市立大学, 医学研究科, 教授 (20423824)
YAGAMI Tatsuro 姫路独協大学, 薬学部, 教授 (00363812)
KAJIWARA Yasuhiro 横浜市立大学, 国際総合科学部, 教授 (50275020)
YURA Kei 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究副主幹 (50252226)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経伝達物質 / 受容体 / 自律神経系 / ドーパ / 電気生理学 |
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| Research Abstract |
DOPA is a novel neurotransmitter candidate in the central nervous system. In an attempt to identify a specific receptor(s) for DOPA, we have searched for selective and stable DOPA ligands. We found a positive fraction in L-threo-dihydroxyphenyserine-containing solution to induce depressor and bradycardic response when microinjected into the nucleus tractus solitarii (NTS) of anesthetized rats. In multiple electrode array system, we also found biphasic response to DOPA in NTS area of rat brain stem slices. While conducting this project, we newly identified a receptor candidate for DOPA.
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[Journal Article] Computational analysis of the effects of antineoplastic agents on axonal transport.2010
Author(s)
Goshima Y, Usui H, Shiozawa T, Hida T, Kuraoka S, Takeshita S, Yamashita N, Ichikawa Y, Kamiya Y, Gotoh T, Gotoh T.
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Journal Title
J Pharmacol Sci. 114
Pages: 168-179
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