2010 Fiscal Year Final Research Report
Systemic analysis of amyloidosis using animal models
| Project/Area Number |
20300144
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Shinshu University |
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Principal Investigator |
HIGUCHI Keiichi Shinshu University, 医学系研究科, 教授 (20173156)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Masayuki 信州大学, 医学系研究科, 准教授 (60273190)
SAWASHITA Jinko 信州大学, 医学系研究科, 助教 (40359732)
KAMETANI Fuyuki (財)東京都医学研究機構, 東京都精神医学総合研究所, 主任研究員 (70186013)
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| Co-Investigator(Renkei-kenkyūsha) |
NAIKI Hironobu 福井大学, 医学部, 教授 (10227704)
MAEDA Shuichiro 山梨大学, 医学工学総合研究部, 教授 (10117244)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アミロイドーシス / マウス / アミロイド線維 / 伝播 / apoA-II,ノックアウトマウス / 熱ショック蛋白質 / リポ蛋白質 |
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| Research Abstract |
Amyloidoses are protein structural disorders characterized by the extracellular deposition of insoluble amyloid fibrils resulting from abnormal conformational changes. We have developed a new analytical system for amyloid fibril formation from synthetic peptides in test tubes and several new mouse strains for studying various kinds of amyloidoses. Using these in vitro and in vivo systems, systemic analysis of amyloidosis was performed to elucidate the pathogenesis of transmission of amyloidosis. We found 1) new transmission routes through feces and skeletal muscle, 2) new therapeutic targets including peptides inhibiting fibril formation, heat shock transcription factor 1 (HSF1) and apolipoprotein A-I, and 3) several newly developed mouse strains variable for amyloidosis researches.
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[Journal Article] Mouse model to study human Aβ32M amyloidosis : Generation of a transgenic mouse with excessive expression of human β32-microglobulin.2010
Author(s)
Zhang P, Fu X, Sawashita J, Yao J, Zhang B, Qian J, Tomozawa H, Mori M, Ando Y, Naiki H, Higuchi K
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Journal Title
Peer Reviewed
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[Journal Article] Fecal translation of AA amyloidosis in the cheetah contributions to high incidence of disease.2008
Author(s)
Zhang B, Une Y, Fu X, Yan J, Ge F, Yao J, Sawashita J, Mori M, Tomozawa H, Kametani F, Higuchi K
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Journal Title
Proc Nat Acad Sci USA 105
Pages: 7263-7268
Peer Reviewed
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[Presentation] Accelerated senile amyloidosis in heat shock transcription factor-1 (Hsfl) deficient mice.2009
Author(s)
Qian J, Zhang B, Wang Y, Fu X, Ge F, Yan J, Sawashita J, Zhang P, Tomozawa H, Mori M, Nakai A, Higuchi K
Organizer
4th International Congress on Stress Responses in Biology and Medicine.
Place of Presentation
Sapporo
Year and Date
2009-10-08
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