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2010 Fiscal Year Final Research Report

Development of Magnetic Resonance Elastography System to Observe Deep Inside of the Body

Research Project

  • PDF
Project/Area Number 20300151
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionChiba University

Principal Investigator

SUGA Mikio  Chiba University, 大学院・工学研究科, 准教授 (00294281)

Co-Investigator(Kenkyū-buntansha) OBATA Takayuki  独立行政法人放射線医学総合研究所, 分子イメージング研究センター・チームリーダー (00285107)
NAKAMURA Gen  北海道大学, 理学研究院, 教授 (50118535)
YAMAMOTO Takao  群馬大学, 工学研究科, 教授 (80200814)
FUJIWARA Hiroshi  京都大学, 情報学研究科, 助教 (00362583)
Project Period (FY) 2008 – 2010
Keywords医用・生体画像 / 生体粘弾性率分布測定 / レオメータ / MRI / MR Elastography
Research Abstract

Magnetic resonance elastography (MRE) can noninvasively visualize shear waves patterns within tissue. To acquire an accurate shear modulus map in high spatial resolution in deep regions, external drivers must generate a precisely controlled high frequency and a large amplitude vibration. In this study, we develop a simple and robustly designed focused acoustic driver to enhance shear wave amplitude in deep regions and imaging programs. From the results of the experimental studies, it was shown that the system acquire an accurate shear modulus map in high spatial resolution in deep regions.

  • Research Products

    (19 results)

All 2011 2010 2009 2008 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (12 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] MR elastography用パルスシーケンスの最適化による弾性波画像上の高調波歪み抑制2011

    • Author(s)
      荒井謙,菅幹生,小澤慎也,平野勝也,小林英津子,小畠隆行
    • Journal Title

      生体医工学 (印刷中)

    • Peer Reviewed
  • [Journal Article] Viscoelastic Properties of Soft Tissues in a Living Body Measured by MR Elastography2011

    • Author(s)
      Jiang Yu, Nakamura Gen
    • Journal Title

      Journal of Physics (印刷中)

    • Peer Reviewed
  • [Journal Article] Inverse viscosity problem for the Navier-Stokes equation2010

    • Author(s)
      Jishan Fan, Michele Di Cristo, Yu Jiang, Gen Nakamura
    • Journal Title

      Journal of Mathematical Analysis and Applications Vol.365, No.2

      Pages: 750-757

    • Peer Reviewed
  • [Journal Article] Inverse problems for the Boussinesq system2009

    • Author(s)
      Jishan Fan, Yu Jiang, Gen Nakamura
    • Journal Title

      Inverse Problems Vol.25

      Pages: 1-10

    • Peer Reviewed
  • [Journal Article] 生体組織の定量的粘弾性率分布測定法-MR Elastography-2008

    • Author(s)
      菅幹生
    • Journal Title

      生体医工学 Vol.46

      Pages: 181-182

  • [Presentation] MR Elastographyによる生体弾性情報の定量測定2011

    • Author(s)
      菅幹生
    • Organizer
      第60回理論応用力学講演会
    • Place of Presentation
      東京工業大学(東京都)(基調講演)
    • Year and Date
      2011-03-09
  • [Presentation] MREによる異方性剛性率の計測理論2011

    • Author(s)
      山本隆夫
    • Organizer
      第60回理論応用力学講演会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2011-03-09
  • [Presentation] MR Elastography-粘弾性率分布定量測定法-2010

    • Author(s)
      菅幹生
    • Organizer
      第14回NMRマイクロイメージング研究会
    • Place of Presentation
      東京海洋大学(東京都)(特別講演)
    • Year and Date
      2010-08-06
  • [Presentation] MREデータ解析手法の数理2010

    • Author(s)
      中村玄
    • Organizer
      第14回NMRマイクロイメージング研究会
    • Place of Presentation
      東京海洋大学(東京都)
    • Year and Date
      2010-08-06
  • [Presentation] MREに対する多倍長精度スペクトル法による3次元数値シミュレーション2010

    • Author(s)
      藤原宏志
    • Organizer
      第59回理論応用力学講演会
    • Place of Presentation
      日本学術会議(東京都)
    • Year and Date
      2010-06-09
  • [Presentation] Focused Acoustic Driver to Generate High-Frequency Shear Waves in Deep Regions for Magnetic Resonance Elastography2010

    • Author(s)
      菅幹生
    • Organizer
      Joint Annual Meeting ISMRM-ESMRMB, 18th Scientific Meeting and Exhibition
    • Place of Presentation
      Stockholm Messe (Sweden)
    • Year and Date
      2010-05-06
  • [Presentation] MREの実現のための粘弾性方程式の数値計算の問題点2009

    • Author(s)
      藤原宏志
    • Organizer
      第59回理論応用力学講演会
    • Place of Presentation
      大阪大学(大阪府)
    • Year and Date
      2009-09-28
  • [Presentation] 一般化されたMREシステムの数理模型2009

    • Author(s)
      山本隆夫
    • Organizer
      第58回理論応用力学講演会
    • Place of Presentation
      日本学術会議(東京都)
    • Year and Date
      2009-06-10
  • [Presentation] Inversion Algorithm by Integral Type Reconstruction Formula for Magnetic Resonance Elastography2009

    • Author(s)
      菅幹生
    • Organizer
      Joint Annual Meeting ISMRM-ESMRMB, 17th Scientific Meeting and Exhibition
    • Place of Presentation
      Hawaii Convention Center (USA)
    • Year and Date
      2009-04-22
  • [Presentation] Mathematical Data Analysis for MRE2008

    • Author(s)
      中村玄
    • Organizer
      SIAM Conference on the Life Sciences
    • Place of Presentation
      Montreal(Canada)
    • Year and Date
      2008-08-04
  • [Presentation] 積分型公式によるMREでの剛性率の再構成2008

    • Author(s)
      藤原宏志
    • Organizer
      第57回理論応用力学講演会講演会
    • Place of Presentation
      日本学術会議(東京都)
    • Year and Date
      2008-06-11
  • [Presentation] 縦波誘起横波によるMRE2008

    • Author(s)
      山本隆夫
    • Organizer
      日本学術会議
    • Place of Presentation
      東京都
    • Year and Date
      2008-06-11
  • [Remarks] ホームページ等

    • URL

      http://www.tms.chiba-u.jp/

  • [Patent(Industrial Property Rights)] 集束型加振装置2009

    • Inventor(s)
      菅幹生,小畠隆行,関根雅
    • Industrial Property Rights Holder
      千葉大学,放射線医学総合研究所
    • Industrial Property Number
      特願,2009-080401
    • Filing Date
      2009-03-27

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Published: 2012-01-26   Modified: 2016-04-21  

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