Research of the introduction the molecular target and anti-angiogenic cancer therapy combined with ultrasound into clinical medicine

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20300182
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: International University of Health and Welfare (2011); Fukuoka University (2008-2010)
• Principal Investigator: EMOTO Makoto Fukuoka University, 医学部, 准教授 (80258540)
• Project Period (FY): 2008 – 2011
• Keywords: 血管新生 / 超音波治療 / 分子標的 / 癌治療 / 血管新生阻害

Research Abstract

本課題は、超音波を併用した癌分子標的・血管新生阻害療法の臨床導入に向けての基礎的研究である。超音波エネルギーは放射線照射とは比較にならない程人体に優しく、悪性腫瘍を中心とした今後の治療手段としての適応拡大が推察される。本研究では、これまでの基礎研究における有用性を踏まえて、がん治療における超音波併用療法の臨床導入に向けての意義を早急に確立することを目的としたものと成る。

Research Products

• [Journal Article] Metronomic irrinotecan combined with ultrasound irradiation for human uterine sarcoma xenografts. (2011)
  • Author(s): Choijamts B, Naganuma Y, Nakajima K, Kawarabayashi T, Tachibana K, Emoto M
  • Journal Title: Cancer Sci 102 Pages: 452-459
  • Peer Reviewed
• [Journal Article] Novel chemoembolization using calcium-phosphate ceramic microsphere incorporating TNP-470, an anti-angiogenic agent. (2010)
  • Author(s): Emoto M, Naganuma Y, Choijamts B, Ohno T, Yoshihisa H, Kanomata N, Kawarabayashi T, Aizawa M
  • Journal Title: Cancer Sci 101 Pages: 984-990
  • Peer Reviewed
• [Journal Article] Endometrial cytologic findings in tamoxifen-treated breast cancer patients. (2009)
  • Author(s): Hachisuga T, Emoto M, Kawarabayashi T, Kamihara Y, Nabeshima K
  • Journal Title: Acta Cytol 53 Pages: 24-28
  • Peer Reviewed
• [Journal Article] Ultrasound imaging and gene delivery by AG73-modified bubble liposomes. (2009)
  • Author(s): Negishi Y, Tsunoda Y, Hamano N, Endo Y, Takagi N, Suzuki R, Maruyama K, Batsuren C, Emoto M, Nomizu M, Aramaki Y
  • Journal Title: Peptide Science Pages: 127-130
  • Peer Reviewed
• [Journal Article] Monitoring of endometrial K-ras mutation in Tamoxifen-treated patients with breast cancer. (2009)
  • Author(s): Tsujioka H, Hachisuga T, Fukuoka M, Ueda T, Miyahara D, Horiuchi S, Yoshizato T, Emoto M, Miyamoto S, Kawarabayashi T
  • Journal Title: Int J Gynecol Cancer 19 Pages: 1052-1056
  • Peer Reviewed
• [Journal Article] The efficacy of preoperative hormonal therapy before laparoscopic cystectomy of ovarian endometriomas. (2009)
  • Author(s): Tsujioka H, Inoue Y, Emoto M, Sadamori R, Shirota K, Hachisuga T, Kawarabayashi T
  • Journal Title: J Obstet Gynecol Res 35 Pages: 782-786
  • Peer Reviewed
• [Journal Article] Anti-tumorigenesis of hollow calcium-phosphate microsphere loaded with anti-angiogenic agent. (2008)
  • Author(s): Aizawa M, Ohno T, Kanomata N, Yano K, Emoto M
  • Journal Title: Key Engineering Materials 361-363 Pages: 1215-1218
  • Peer Reviewed
• [Journal Article] Evaluation of the factors predicting the outcome of transsphenoidal microsurgery in patients with premenopausal microprolactinoma. (2008)
  • Author(s): Tsugu H, Emoto M, Oshiro S, Komatsu F, Sakamoto S, Ohta M, Fukushima T
  • Journal Title: Med Bull Fukuoka Univ 35 Pages: 1-6
  • Peer Reviewed
• [Journal Article] 婦人科癌化学療法時の悪心・嘔吐に対するインジセトロン塩酸塩の有効性および安全性 (2008)
  • Author(s): 牛嶋公生、和氣徳夫、小林裕明、蜂須賀徹、土岐尚之、増崎英明、小寺宏平、瓦林達比古、江本精、嘉村敏治
  • Journal Title: 癌と化学療法 35 Pages: 1169-1173
  • Peer Reviewed
• [Book] 新臨床腫瘍学(子宮肉腫) (2009)
  • Author(s): 江本精
  • Total Pages: 599-601
  • Publisher: 南江堂、東京
• [Book] 老年腫瘍学Geriatric Oncology(総論II高齢者の生理、病態生理 婦人科領域(女性生殖器))(田村和夫, 鍋島一樹, 鈴宮淳司編) (2008)
  • Author(s): 江本精
  • Total Pages: 66-68
  • Publisher: 文光堂、東京
• [Book] 老年腫瘍学Geriatric Oncology(各論:子宮頸癌)(田村和夫, 鍋島一樹, 鈴宮淳司編) (2008)
  • Author(s): 江本精
  • Total Pages: 242-249
  • Publisher: 文光堂、東京
• [Book] 老年腫瘍学Geriatric Oncology(各論:子宮体癌)(田村和夫, 鍋島一樹, 鈴宮淳司編) (2008)
  • Author(s): 江本精
  • Total Pages: 249-254
  • Publisher: 文光堂、東京
• [Book] 老年腫瘍学Geriatric Oncology(各論:卵巣癌)(田村和夫、鍋島一樹、鈴宮淳司編) (2008)
  • Author(s): 江本精
  • Total Pages: 255-261
  • Publisher: 文光堂、東京