2010 Fiscal Year Final Research Report
Development of nano-particles with tumor retention by single molecular DDS imaging
| Project/Area Number |
20310067
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Tohoku University |
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Principal Investigator |
OHUCHI Noriaki Tohoku University, 大学院・医学系研究科, 教授 (90203710)
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| Co-Investigator(Kenkyū-buntansha) |
KASUYA Atsuo 東北大学, 国際高等研究教育機構, 客員教授 (10005986)
TAKEDA Motohiro 東北大学, 大学院・医学系研究科, 准教授 (10333808)
AMARI Masakazu 東北大学, 病院, 講師 (50400312)
KAWAI Masaaki 東北大学, 大学院・医学系研究科, 客員准教授 (80513530)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生体内イメージング / 転移 / ナノ粒子 / 腫瘍滞留性ナノ粒子 / 高分子ミセル / ドラッグデリバリーシステム |
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| Research Abstract |
To develop an effective anticancer drug, the understanding of cancer mechanisms and drug delivery system (DDS) is very important. Here, we have developed a method for in vivo imaging with very high spatial accuracy and succeeded in tracking the membrane protein PAR1 during metastasis in living mice. To investigate drug movement in association to its size in tumor, fluorescent nano-particles were injected into the tumor-bearing mice and visualized by in vivo imaging. Additionally, we developed a novel method to evaluate the structural stability and anti-cancer effect of drug-incorporating polymeric micelles.
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