2010 Fiscal Year Final Research Report
Development of Gold-and Palladium-catalyzed New Transformations via Modification of Ligands
| Project/Area Number |
20350015
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
JIN Tienan 東北大学, 原子分子材料科学高等研究機構, 准教授 (80431493)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 反応有機化学 |
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| Research Abstract |
Novel Pd-and Au-catalyzed molecular transformations have been developed through the modification of ligands and counter anions which showed high reactivity and selectivity. A variety of Norbornane derivatives have been synthesized and successfully used in the Pd-catalyzed asymmetric intramolecular hydroamination of alkynes. The newly prepared (R, R)-methyl norphos and (R, R)-toly renorphos afforded N-containing heterocyles in high yields and high enantio-selectivity. Moreover, novel Pd-catalyzed allylative dearomatization and three-component cycloaddition were developed. We have succeeded in development of cationic Au-catalyzed hydroalkoxylation and hydrothiolation. Moreover, we also succeeded in construction of thienocarbazole frameworks via a new Au-catalyzed cascade cyclization of arydiynes, which was further applied in the synthesis of D-A-D organic electronic materials. Various O-, S-and N-containing heterocyles bearing diiodine substituents have been synthesized through the facile and efficient electrophilic iodocyclizations.
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