2010 Fiscal Year Final Research Report
Development of DNA-binding ligands detecting trinucleotide repeats
| Project/Area Number |
20350032
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Analytical chemistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 核酸 / トリヌクレオチドリピート / ミスマッチ塩基対 / リガンド / 相互作用 / 蛍光検出 |
|---|
| Research Abstract |
Recent molecular genetic studies have shown that expansion of DNA trinucleotide repeats cause human neurological diseases, which are called trinucleotide repeat disorder. Unfortunately, there are no effective therapeutic approaches for the treatment of these diseases. In this work, we have successfully developed fluorescent ligands for C-C mismatch detection in CCG trinucleotide repeats that are associated with fragile site XE-linked mental retardation. It is expected that the discovery of such small molecules that bind trinucleotide repeats would provide a method for the smart diagnosis of the repeated length and a rational basis for the development of effective therapeutic agents.
|
