2010 Fiscal Year Final Research Report
New Trial toward the Construction of Self-Assembling Supramolecular Hemoproteins
| Project/Area Number |
20350079
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Osaka University |
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Principal Investigator |
HAYASHI Takashi Osaka University, 工学研究科, 教授 (20222226)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ヘムタンパク質 / 超分子ポリマー / ヘム / アポタンパク質 / 金コロイド / タンパク質修飾基板 |
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| Research Abstract |
A series of hemoproteins, which are ubiquitous in nature, are holoproteins with a heme molecule as a prosthetic group. In this study, we firstly found that the successive self-assembly structure of hemoproteins is available when we introduced a heme moiety onto the apohemoprotein surface via covalent linkage. Furthermore, we demonstrated that the multilayer of hemoproteins can be immobilized onto the gold surface by same strategy.
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