2010 Fiscal Year Final Research Report
Exciton-controlled imaging for effective spatiotemporal analysis of nucleic acid functions
| Project/Area Number |
20350083
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
OKAMOTO Akimitsu The Institute of Physical and Chemical Research, 岡本独立主幹研究ユニット, ユニットリーダー(独立主幹研究員) (60314233)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 励起子相互作用 / 蛍光イメージング / 蛍光色素 / DNA |
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| Research Abstract |
A series of near-infrared fluorescent probes was designed based on the concept of emission control caused by interdye excitonic interaction. The fluorescent probes showed very weak emission in the unhybridized state, whereas they emitted near-infrared fluorescence after hybridization with the complementary nucleic acid. The hybridization-dependent switching of fluorescence emission made it possible to monitor mRNA in a human cell in the range of near-infrared wavelengths.
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[Presentation] Design of a fluorescent probe for DNA/RNA imaging2008
Author(s)
Akimitsu Okamoto, Takeshi Kubota, Shuji Ikeda
Organizer
joint Symposium of 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and 35th International Symposium on Nucleic Acids Chemistry
Place of Presentation
Kyoto, Japan
Year and Date
20080900
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