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2010 Fiscal Year Final Research Report

Ion transport control of cell membrane by developing sensing technique using evanescent wave for refractive index and electrostatic potential of cell

Research Project

  • PDF
Project/Area Number 20360102
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thermal engineering
Research InstitutionKeio University

Principal Investigator

SATO Yohei  Keio University, 理工学部, 准教授 (00344127)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Toshiyuki  慶應義塾大学, 理工学部, 教授 (00255598)
Project Period (FY) 2008 – 2010
Keywordsマイクロ流体デバイス / 細胞表面電位 / 細胞内屈折率 / エバネッセント波 / マイクロPIV / マイクロLIF
Research Abstract

A non-invasive sensing technique using evanescent wave for the refractive index and electrostatic potential of cell was developed in order to control ion transport between cell and culture solution in microfluidic device. A novel technique to detect refractive index difference was proposed utilizing light scattering by evanescent wave illumination. A color imaging of electrostatic potential distribution was achieved by developing a two-color LIF technique.

  • Research Products

    (10 results)

All 2010 2009 2008 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] エバネッセント波および体積照射を用いた非一様ゼータ電位を有する電気浸透流の時系列速度計測2010

    • Author(s)
      嘉副裕,中村翼,佐藤洋平
    • Journal Title

      日本機械学会論文集B編 第76巻770号

      Pages: 1455-1463

    • Peer Reviewed
  • [Journal Article] Evanescent-wave/volume illuminated velocity measurements of transient eletrokinetically-driven flow with nonuniform wall electrostatic potential2010

    • Author(s)
      Yutaka Kazoe, Tsubasa Nakamura, Yohei Sato
    • Journal Title

      Measurement Science and Technology Vol.21

      Pages: 055401(10)

    • Peer Reviewed
  • [Journal Article] Fluorescence imaging technique of surface electrostatic potential using evanescent wave illumination2009

    • Author(s)
      Yutaka Kazoe, Shu Miyakawa, Norihisa Miki, Yohei Sato
    • Journal Title

      Applied Physics Letters Vol.95

      Pages: 234104(3)

    • Peer Reviewed
  • [Presentation] Refractive index difference sensing illuminated by evanescent wave for noninvasive diagnosis of cell's pathological state2010

    • Author(s)
      栗山怜子, 田中雄太, 佐藤洋平
    • Organizer
      International Symposium on Micro-Nano Mechatronics and Human Science
    • Place of Presentation
      (CD-ROM)
    • Year and Date
      2010-11-08
  • [Presentation] 非侵襲細胞状態判別を実現するエバネッセント波照射屈折率差計測法の開発2010

    • Author(s)
      栗山怜子,田中雄太,佐藤洋平
    • Organizer
      第47回日本伝熱シンポジウム講演論文集(Vol.1 pp.109-110)
    • Year and Date
      2010-05-26
  • [Presentation] Quantitative evaluation of patterned self-assembled monolayers by color imaging of zeta-potential obtained from two-color fluorescence and evanescent wave illumination2008

    • Author(s)
      Yutaka Kazoe, Shu Miyakawa, Norihisa Miki, Yohei Sato
    • Organizer
      Micro Total Analysis Systems(Vol.1 2008 pp.643-645)
    • Year and Date
      2008-10-13
  • [Remarks] 受賞社団法人日本伝熱学会優秀プレゼンテーション賞(2010年5月26日)

  • [Remarks] ホームページ

    • URL

      http://www.tfe.sd.keio.ac.jp/

  • [Patent(Industrial Property Rights)] Quantitative evaluation method and device for zeta potential, pH or temperature distribution at wall surface and quantitative visualization method and device for surface modification2010

    • Inventor(s)
      佐藤洋平、嘉副裕、宮川修
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Industrial Property Number
      特許,WO2010/041560
    • Filing Date
      2010-04-15
  • [Patent(Industrial Property Rights)] 二色蛍光色素を用いたゼータ電位定量法2008

    • Inventor(s)
      佐藤洋平、嘉副裕、宮川修
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Industrial Property Number
      特許,特願2008-263639
    • Filing Date
      2008-10-10

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Published: 2012-01-26   Modified: 2016-04-21  

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