2010 Fiscal Year Final Research Report
Dynamics of giant liposomes and cellular signal tranduction
| Project/Area Number |
20360370
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Japan Advanced Institute of Science and Technology |
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Principal Investigator |
TAKAGI Masahiro Japan Advanced Institute of Science and Technology, マテリアルサイエンス研究科, 教授 (00183434)
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Tsutomu 北陸先端科学技術大学院大学, マテリアルサイエンス研究科, 助教 (40432140)
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| Project Period (FY) |
2008 – 2010
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| Keywords | リポソーム / ダイナミクス / 細胞信号伝達 |
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| Research Abstract |
Rafts are dynamic clusters composed largely of cholesterol and sphingolipids. Microdomains are expected to function as platforms of endocytic carriers. Along these lines, giant multicomponent liposomes, raft-exhibiting model membranes, are efficient tools for studying the physicochemical properties of microdomains. We have shown that some simple stimuli (osmosis or detergents) may induce bud formation of raft domains in model membranes. We also showed interaction between amyloid beta (Aβ) and model membranes. Moreover, morphological changes might be related to the neurotoxicity in the pathology of Alzheimer's disease (AD). We used both liposomes and actual living cells for studies of dynamic movement of membrane structure.
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