2010 Fiscal Year Final Research Report
Regulation of microtubule cytoskeleton by phosphorylation
| Project/Area Number |
20370023
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
HASHIMOTO Takashi Nara Institute of Science and Technology, バイオサイエンス研究科, 教授 (80180826)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 微小管 / リン酸化 / フォスファターゼ / キナーゼ / アラビドプシス |
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| Research Abstract |
Phosphorylation of plant microtubules was investigated with respects to tubulin phosphorylation and protein phosphatases. I found that the Arabidopsis Propyzamide-Hypersensitive 1 protein of the mitogen-activated protein kinase phosphatase family also possesses a kinase domain of atypical protein kinases. The kinase activity is suppressed by the intra-molecular phosphatase activity, but when this suppression is removed, the activated kinase rapidly phosphorylates tubulin and depolymerizes cortical microtubules.
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