2010 Fiscal Year Final Research Report
Biosynthesis and Folding of Membrane Proteins
| Project/Area Number |
20370041
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | University of Hyogo |
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Principal Investigator |
MASAO Sakaguchi University of Hyogo, 大学院・生命理学研究科, 教授 (30205736)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 膜タンパク質 / シグナル配列 / トポロジー / 生体膜 / オルガネラ |
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| Research Abstract |
We have been working on the biosynthesis of various membrane proteins. In this project, we found the follows. The signal sequence, which triggers translocation of polypeptide chain, provides the motive force for polypeptide chain translocation. Positive charges of polypeptide chain cause stop-translocation in the membrane. A certain sequence suppresses a targeting of hydrophobic segment to endoplasmic reticulum.
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[Journal Article] Multiple organelle-targeting signals in the N-terminal portion of peroxisomal membrane protein PMP702010
Author(s)
Iwashita, S., Tsuchida, M., Tsukuda, M., Yamashita, Y., Emi, Y., Kida Y. Komori, M., Kashiwayama, Y., Imanaka, T., Sakaguchi M.
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Journal Title
J.Biochem. 147(4)
Pages: 581-590
Peer Reviewed
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[Journal Article] 70-kDa peroxisomal membrane protein related protein (P70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins2009
Author(s)
Kashiwayama, Y., Seki, M., Yasui, A., Murasaki, Y., Morita, M., Yamashita, Y., Sakaguchi M., Tanaka, Y., Imanaka, T.
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Journal Title
Exp.Cell Res. 315
Pages: 190-205
Peer Reviewed
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