2010 Fiscal Year Final Research Report
Elucidation of protein dynamics as the control of protein function
| Project/Area Number |
20370062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
KATAOKA Mikio Nara Institute of Science and Technology, 物質創成科学研究科, 教授 (30150254)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIBKUBO Hironari 奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (20311128)
YAMAZAKI Yoichi 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (40332770)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAGAWA Hiroshi 日本原子力研究開発機構, 量子ビーム応用研究部門, 研究員 (20379598)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 中性子散乱 / 蛋白質動力学 / 誘導折り畳み / 水和 / 動力学転移 |
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| Research Abstract |
We succeeded to create an functionally active mutant without native structure under physiological condition. Using the mutant and wild type, neutron incoherent scattering experiments were performed under various hydration levels to reveal the protein dynamics required for function. Protein dynamics relevant for function is controlled by hydration water, and the hierarchical structures of protein dynamics are dependent on the conformational states. The essential property of hydration water is revealed to be the formation of hydrogen bond network between hydration water molecules.
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