2010 Fiscal Year Final Research Report
Molecular and temporal-spatial regulation of ubiquitin ligase , F-box protein
| Project/Area Number |
20370076
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKAYAMA Keiko Tohoku University, 大学院・医学系研究科, 教授 (60294972)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Noriko 東北大学, 大学院・医学系研究科, 助教 (10361073)
FUNAYAMA Ryo 東北大学, 大学院・医学系研究科, 助教 (20452295)
NAKANO Seiji 東北大学, 大学院・医学系研究科, 助手 (00529448)
DEL CARPIO Munoz Carlos Adriel 東北大学, 大学院・工学研究科, 准教授 (20231053)
NISHIDA Yuichiro 東北大学, 大学院・医学系研究科, 助教 (00551821)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ユビキチンリガーゼ / β-TrCP1 / Fbxw7 / ノックアウトマウス / ES細胞 |
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| Research Abstract |
F-box protein functions as a ubiquitin ligase constructing SCF protein complex. In this preject, I focused my interest on typical F-box proteins, Fbxw7 and β-TrCP. I analyzed their gene targeting mice to elucidate the biological function of these proteins. Although Fbxw7 suppressed tumorigenesis in T lymphocytes and hematopoietic stem cell, it facilitated cell proliferation in primary embryonic fibroblasts and keratinocytes. b-TrCP promoted cell proliferation.
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Research Products
(23 results)
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[Journal Article] Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/-mice.2010
Author(s)
Wang, H., F.Bauzon, P.Ji, X.Xu, D.Sun, J.Locker, R.S.Sellers, K.Nakayama, K.I.Nakayama, D.CobrinikL. Zhu
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Journal Title
Nat Genet 42
Pages: 83-88
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[Journal Article] Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration.2009
Author(s)
Kimura, T., M.Sakai, K.Tabu, L.Wang, R.Tsunematsu, M.Tsuda, H.Sawa, K.Nagashima, H.Nishihara, S.Hatakeyama, K.Nakayama, M.Ladanyi, S.Tanaka, K.I.Nakayama
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Journal Title
Lab Invest 89
Pages: 645-656
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[Journal Article] Mechanoregulation of proliferation.2009
Author(s)
Jiang, X., P.F.Austin, R.A.Niederhoff, S.R.Manson, J.J.Riehm, B.L.Cook, G.Pengue, K.Chitaley, K.Nakayama, K.I.Nakayama, S.J.Weintraub
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Journal Title
Mol Cell Biol 29
Pages: 5104-5114
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[Journal Article] Protein kinase C[delta] differentially regulates platelet functional responses.2009
Author(s)
Chari, R., T.Getz, B.Nagy, Jr., K.Bhavaraju, Y.Mao, Y.S.Bynagari, S.Murugappan, K.Nakayama, S.P.Kunapuli
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Journal Title
Arterioscler Thromb Vasc Biol 29
Pages: 699-705
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