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2010 Fiscal Year Final Research Report

Analysis of the membrane stress response in E. coli

Research Project

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Project/Area Number 20370078
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionKyoto University

Principal Investigator

AKIYAMA Yoshinori  京都大学, ウイルス研究所, 教授 (10192460)

Co-Investigator(Kenkyū-buntansha) MORI Hiroyuki  京都大学, ウイルス研究所, 准教授 (10243271)
Project Period (FY) 2008 – 2010
Keywords生体膜
Research Abstract

To elucidate the mechanism of activation of extracytoplasmic stress response by abnormal membrane proteins("membrane stress response),(1) we isolated and analyzed suppressor mutations against a class of the secY mutations that elicit membrane stress response, and(2) from the analysis of RseP PDZ domain mutants, we suggest a new Sigma E activation memsahib via ligand binding to the PDZ domains.

  • Research Products

    (12 results)

All 2010 2009 2008 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Quality control of cytoplasmic membrane proteins in Escherichia coli2009

    • Author(s)
      Akiyama, Y.
    • Journal Title

      J. Biochem.

      Volume: 46 Pages: 449-454

    • Peer Reviewed
  • [Journal Article] The Sec protein secretion system2009

    • Author(s)
      Ito, K. and Mori, H.
    • Journal Title

      Bacterial Secreted Proteins

      Pages: 3-22

  • [Journal Article] Substrate recognition and binding by RseP, an Escherichia coli intramembrane protease2008

    • Author(s)
      Koide, K., Ito. K., and Akiyama, Y.
    • Journal Title

      J. Biol. Chem.

      Volume: 283 Pages: 9562-9570

    • Peer Reviewed
  • [Journal Article] Conformational transition of Sec machinery inferred from bacterial SecYE structures2008

    • Author(s)
      Tsukazaki, T., Mori, H., Fukai, S., Ishitani, R., Mori, T., Dohmae, N., Perederina, A., Sugita, Y., Vassylyev, D. G., Ito, K. andNureki O.
    • Journal Title

      These authors contributed equally to thiswork

      Volume: 455 Pages: 988-991

    • Peer Reviewed
  • [Journal Article] A pair of circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of E. coli2008

    • Author(s)
      Inaba, K., Suzuki, M., Maegawa, K., Akiyama, S., Ito, K., and Akiyama, Y.
    • Journal Title

      J. Biol. Chem.

      Volume: 283 Pages: 35042-35052

    • Peer Reviewed
  • [Presentation] 大腸菌表層ストレス応答に関わるS2P膜内プロテアーゼRsePのPDZドメイン機能の解析2010

    • Author(s)
      檜作洋平、秋山芳展
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20101207-10
  • [Presentation] Roles of the two PDZ domains of RseP, the S2P family intramembrane protease of Escherichia coli, in regulation of its protease function2010

    • Author(s)
      Hizukuri, Y. and Akiyama, Y.
    • Organizer
      The 3rd International Symposium on Protein Community, Nara
    • Place of Presentation
      Japan
    • Year and Date
      20100913-16
  • [Presentation] New function of RseP, the E. coli S2P family protease2010

    • Author(s)
      Akiyama, Y.
    • Organizer
      New function of RseP, the E. coli S2P family protease. Gordon Research Conference on Proteolytic enzymes & the irinhibitors
    • Place of Presentation
      Lucca, Italy
    • Year and Date
      20100502-07
  • [Presentation] A pair of circularly permutated PDZ domains control RsePRse, the S2P family intramembrane protease of E. coli.2009

    • Author(s)
      Inaba, K., Suzuki, M., Maegawa, K.-i., Akiyama, S., Ito, K. and Akiyama, Y.
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      20091021-24
  • [Presentation] 大腸菌S2PプロテアーゼRsePの膜タンパク質品質管理における新たな役割2008

    • Author(s)
      斎藤啓、秋山芳展
    • Organizer
      第5回21世紀大腸菌研究会
    • Place of Presentation
      藤枝
    • Year and Date
      20080728-29
  • [Presentation] 大腸菌RIPプロテアーゼの機能と制御.ワークショップ「直接性、不可逆性を特徴とする新しいシグナル伝達のメカニズム」2008

    • Author(s)
      秋山芳展
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-11
  • [Remarks]

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/akiyama/index.html

URL: 

Published: 2013-07-31  

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