Basic study on the development of novel anticancer drugs utilizing bioactive substances from insects

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20380039
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied entomology
• Research Institution: National Institute of Agrobiological Sciences
• Principal Investigator: YAMAKAWA Minoru National Institute of Agrobiological Sciences, 昆虫科学研究領域, 特任上級研究員 (30183677)
• Project Period (FY): 2008 – 2012
• Keywords: 昆虫利用 / 機能開発

Research Abstract

本研究の目的は、従来の抗ガン剤とは全く作用機構の異なる新規抗ガン剤開発のための基礎的知見を得ることである。そのために
(1)昆虫由来抗微生物タンパク質改変ペプチドの抗ガン作用の解明と(2)昆虫由来新規抗ガン活性物質の探索の二つの課題について研究を進めている。この二課題の研究遂行を通じ、新規抗ガン剤開発のためのシーズを得る。

Research Products

• [Journal Article] 昆虫抗微生物ペプチドを用いた生体防御研究-改変ペプチドの抗菌・抗ガン活性と作用機構- (2010)
  • Author(s): 山川稔、岩崎崇、石橋純
  • Journal Title: 感染・炎症・免疫 40 Pages: 6-15
• [Journal Article] Selective cancer cell cytotoxicity of enantiomeric 9-mer peptides derived from beetle defensins depends on negatively charged phosphadidylserine on the cell surface. (2009)
  • Author(s): Iwasaki, T., Ishibashi, J., Saido-Sakanaka, H., Tanaka, H., Sato, M., Asaoka, A., Taylor, D.,Yamakawa, M
  • Journal Title: Peptides 30 Pages: 660-668
  • Peer Reviewed
• [Journal Article] Multiple functions of short enantiomeric peptides based on beetle defensins. (2009)
  • Author(s): Iwasaki, T., Ishibashi, J., Kubo, M., Taylor, D., Yamakawa, M.
  • Journal Title: Biosci.Biotechnol. Biochem. 73 Pages: 683-687
  • Peer Reviewed
• [Journal Article] Multi-target of enantiomeric 9-mer peptides derived from beetle defensins. (2009)
  • Author(s): Iwasaki, T., Ishibashi, J., Tanaka, H., Sato, M., Asaoka, A., Taylor, D., Yamakawa, M.
  • Journal Title: Peptide Science 2008 Pages: 51-59
  • Peer Reviewed
• [Journal Article] Antibacterial and anticancer activity of diasteromeric 9-mer peptides derived from beetle defensins. (2008)
  • Author(s): Iwasaki, T., Ishibashi, J., Saido-Sakanaka, H., Tanaka, H., Sato, M., Asaoka, A., Taylor, D.,Yamakawa, M.
  • Journal Title: Peptide Science 2007 Pages: 79-82
  • Peer Reviewed
• [Presentation] Mitochondoria disruptive 9-mer peptides conjugated with tumor homing domain : cyclic RGD motif (2009)
  • Author(s): Iwasaki, T., Yamakawa, M., et al.
  • Organizer: 第46回ペプチド討論会
  • Place of Presentation: 北九州市
  • Year and Date: 20091104-20091106
• [Presentation] Multi-target of enanteromeric 9-mer peptides derived from beetle defensins (2009)
  • Author(s): Iwasaki, T., Yamakawa, M. et al.
  • Organizer: 2009 Keystone Symposia
  • Place of Presentation: カナダ、ウイスラー
  • Year and Date: 2009-03-29
• [Presentation] カブトムシディフェンシン由来改変ペプチドの多機能解析 (2009)
  • Author(s): 岩崎 崇、山川 稔他
  • Organizer: 平成21年度蚕糸・昆虫機能利用学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-21
• [Presentation] Multi-target of enanteromeric 9-mer peptides derived from beetle defensins. (2008)
  • Author(s): Iwasaki, T., Yamakawa, M., et al.
  • Organizer: 日本ペプチド学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-29
• [Presentation] カブトムシディフェンシン由来改変ペプチドのマルチターゲット (2008)
  • Author(s): 岩崎 崇、山川 稔他
  • Organizer: 第41回若手ペプチド夏の勉強会
  • Place of Presentation: 京都
  • Year and Date: 2008-08-04
• [Patent(Industrial Property Rights)] 新規ビフェニール化合物 (2010)
  • Inventor(s): 亀山真由美、石橋純、山川稔、米田泰崇、吉田充
  • Industrial Property Rights Holder: 農業生物資源研究所、食品総合研究所
  • Industrial Property Number: 特許,2010-164384
  • Filing Date: 2010-07-21