2010 Fiscal Year Final Research Report
Elucidation of immunoregulatory function of intestinal immunoregulatory cells and its application to anti-infectious and anti-allergic food
| Project/Area Number |
20380074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HACHIMURA Satoshi The University of Tokyo, 大学院・農学生命科学研究科, 准教授 (40238019)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Yoshimasa 国立感染症研究所, 免疫部, 室長 (60311403)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 免疫機能食品 / 腸管 / 機能性食品 / アレルギー / 樹状細胞 / 経口免疫寛容 / IgA抗体 / 制御性T細胞 |
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| Research Abstract |
In this study, we tried to elucidate the immune regulating functions of intestinal regulatory cells . This should be important in the development of novel immune functional foods. We examined the response of dendritic cells of Peyer's patch, an intestinal immune organ, to microbial components, analyzed the characteristics of CD3^-IL-2R^+ cells, a unique cell population in the intestine, and established an infection mouse model. We further elucidated the function of two types of regulatory T cells induced in oral tolerance, which is a suppressive mechanism of food allergy, and demonstrated the role of dendritic cells in its induction.
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Research Products
(16 results)
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[Journal Article] Intestinal commensal bacteria promote T cell hyporesponsiveness and down-regulate the serum antibody responses induced by dietary antigen.2010
Author(s)
Tsuda, M,.Hosono, A, Yanagibashi, T., Kihara-Fujioka, M., Hachimura, S., Itoh, K., Hirayama, K., Takahashi, K., Kaminogawa, S.
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Journal Title
Immunol.Lett. 132
Pages: 45-52
Peer Reviewed
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[Journal Article] Lack of antibody response to Guillain-Barre syndrome-related gangliosides in mice and men after novel influenza vaccination.2010
Author(s)
Yuki, N., Takahashi, Y., Ihara, T., Ito, S., Nakajima, T., Funakoshi, K., Furukawa, K., Kobayashi, K., Odaka, M.
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Journal Title
J.Neurol.Neurosurg.Psychiatry. (掲載確定)
Peer Reviewed
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[Journal Article] Protective immunity afforded by H5N1 (NIBRG-14)-inactivated vaccine requires both antibodies against hemagglutinin and neuraminidase.2009
Author(s)
Takahashi, Y., Hasegawa, H., Hara, Y., Ato, M., Ninomiya, A., Takagi, H., Odagiri, T., Sata, T., Tashiro, M., Kobayashi, K.
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Journal Title
J.Infect.Dis. 199
Pages: 1629-1637
Peer Reviewed
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[Journal Article] Intestinal Bifidobacterium association in germ-free T cell receptor transgenic mice down-regulates dietary antigen-specific immune responses of the small intestine but enhances those of the large intestine.2009
Author(s)
Tsuda, M., Hosono, A., Yanagibashi,T., Hachimura S., Hirayama, K., Umesaki, Y., Itoh, K., Takahashi, K., Kaminogawa, S.
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Journal Title
Peer Reviewed
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[Journal Article] Bacteroides induce higher IgA production than Lactobacillus by increasing activation-induced cytidine deaminase expression on B cells in murine Peyer's patches.2009
Author(s)
Yanagibashi, T., Hosono, A., Oyama, T., Tsuda, M., Hachimura, S., Takahashi, Y., Itoh, K., Hirayama, K., Takahashi K., Kaminogawa, S.
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Journal Title
Biosci.Biotechnol.Biochem. 73
Pages: 372-377
Peer Reviewed
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[Journal Article] Suppressive effects ofBifidobacterium longum on the production of Th2-attracting chemokines induced with T cell-antigen-presenting cell interactions.2009
Author(s)
Iwabuchi, N., Takahashi, N., Xiao, J-Z., Yonezawa, S., Yaeshima, T., Iwatsuki, K., Hachimura, S.
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Journal Title
FEMS Immunol.Med.Microbiol. 55
Pages: 323-334
Peer Reviewed
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