2011 Fiscal Year Final Research Report
Regulation of intracellular localization of ENaC by protease
| Project/Area Number |
20390060
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NIISATO Naomi 京都府立医科大学, 医学研究科, 准教授 (00237645)
NAKAJIMA Ken-ichi 京都府立医科大学, 医学研究科, 助教 (40398392)
KUSUZAKI Katsuyuki 平安女学院, 文化創造センター, 客員教授 (30177993)
ASHIHARA Eishi 京都府立医科大学, 医学研究科, 講師 (70275197)
HOSOGI Shigekuni 京都府立医科大学, 医学研究科, 助教 (30405261)
|
|---|
| Project Period (FY) |
2008 – 2011
|
| Keywords | ENaC / アルデステン / 皮質集合管 / プロテアーゼ阻害剤 / 浸透圧 / トラッフィッキング / 高血圧 / ナトリウム輸送 |
|---|
| Research Abstract |
We tried to clarify the regulation of intracellular localization of ENaC by protease. We have found that : 1) aldosterone increases expression of protease, and 2) aldosterone elevates the recycling efficiency of ENaC in the intracellular space by cleavage of ENaC mediated through protease.
|
Research Products
(18 results)
-
-
-
-
[Journal Article] Regulation of epithelial sodium transport via epithelial Na^+channel(ENaC)2011
Author(s)
MARUNAKA Y, Niisato N, Taruno A, Ohta M, Miyazaki H, Hosogi S, Nakajima K, Kusuzaki K, Ashihara E, Nishio K, Iwasaki Y, Nakahari T, Kubota T
-
Journal Title
J Biomed Biotechnol
Volume: 2011
Pages: 978196
Peer Reviewed
-
-
-
[Journal Article] PPAR-alpha modulation of Ca^<2+>-regulated exocytosis via arachidonic acid in guinea pig antral mucous cells2010
Author(s)
Sawabe Y, Shimamoto C, Sakai A, Kuwabara H, Saad AH, Nakano T, Takitani K, Tamai H, Mori H, MARUNAKA Y, Nakahari T
-
Journal Title
Exp Physiol
Volume: 95
Pages: 858-868
Peer Reviewed
-
-
-
[Journal Article] Regulation of paracellular Na^+and Cl^-conductances by hydrostatic pressure2009
Author(s)
Tokuda S, Niisato N, Nagai T, Taruno A, Nakajima K, Miyazaki H, Yamada T, Hosogi S, Ohta M, Nishio K, Iwasaki Y, MARUNAKA Y
-
Journal Title
Cell Biol Int
Volume: 33
Pages: 949-956
Peer Reviewed
-
-
-
[Journal Article] Chloride ions control the G1/S cell-cycle checkpoint by regulating the expression of p21 through a p53-independent pathway in human gastric cancer cells2008
Author(s)
Miyazaki H, Shiozaki A, Niisato N, Ohsawa R, Itoi H, Ueda Y, Otsuji E, Yamagishi H, Iwasaki Y, Nakano T, Nakahari T, MARUNAKA Y
-
Journal Title
Biochem Biophys Res Commun
Volume: 366
Pages: 506-512
Peer Reviewed
-
-
-
-
-
