2010 Fiscal Year Final Research Report
Analyses of an orphan metabotropic receptor and a secretion protein encoded by the same gene
| Project/Area Number |
20390062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
KUBO Yoshihiro National Institute for Physiological Sciences, 分子生理研究系, 教授 (80211887)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生理学 / 神経科学 / 生体分子 / 蛋白質 / シグナル伝達 |
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| Research Abstract |
Prrt3-Long is a member of family C metabotropic receptors whose ligand has not been identified yet. From the same Prrt3 gene, a secretion protein Prrt3-Short, which consists of only the N-terminal extracellular region of Prrt3-Long, is transcribed by splice variation. To obtain clues of their function, we raised specific antibodies and analyzed their expression pattern in the mouse. Prrt3-Long protein was observed to be expressed in the pars tuberalis where melatonin receptor is also known to be expressed. Prrt3-Short protein was observed to be expressed in the choroid plexus in the brain ventricles. From these expression patterns, it was suggested that Prrt3-Long possibly plays a role in the photoperiodism and that Prrt3-Short might be a humoral factor which regulates the brain function.
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