Treatment intervention pathway analysis of genes associated with schizophrenia

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390098
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human genetics
• Research Institution: University of Tsukuba
• Principal Investigator: ARINAMI Tadao University of Tsukuba, 大学院・人間総合科学研究科, 教授 (10212648)
• Project Period (FY): 2008 – 2010
• Keywords: ゲノム医科学

Research Abstract

The purpose of this study is to identify candidate genes of treatment target for schizophrenia. We searched for genes associated with schizophrenia by genome-wide association methods in Japanesepopulations. Among the potentially associated genes identified, we focused on the SMARCA2 gene because psychotogenic drugs lowered Smarca2 expression while antipsychotic drugs increased it in the mouse brain. Furthermore, we found constant expression of Homer1a isoform in Smarca2 knockout mice. The findings of this study indicate that decreased function of SMRACA2 is involved in schizophrenia through glutamatergic synaptic transmission dysfunction and the SMARCA2 gene genotypes might be potential information of personalized medicine in choice of treatment of schizophrenia.

Research Products

• [Journal Article] Functional polymorphism in the GPR55 gene is associated with anorexia nervosa. (2011)
  • Author(s): Ishiguro H, Onaivi ES, Horiuchi Y, Imai K, Komaki G, Ishikawa T, Suzuki M, Watanabe Y, Ando T, Higuchi S, Arinami T.
  • Journal Title: Synapse 65(2) Pages: 103-108
  • Peer Reviewed
• [Journal Article] An association study between the dymeclin gene and schizophrenia in the Japanese population. (2010)
  • Author(s): Yazaki S, Koga M, Ishiguro H, Inada T, Ujike H, Itokawa M, Otowa T, Watanabe Y, Someya T, Iwata N, Kunugi H, Ozaki N, Arinami T.
  • Journal Title: J Hum Genet. 55(9) Pages: 631-634
  • Peer Reviewed
• [Journal Article] Functional polymorphism in the GPR55 gene is associated with anorexia nervosa. (2010)
  • Author(s): Ishiguro H, Onaivi ES, Horiuchi Y, Imai K, Komaki G, Ishikawa T, Suzuki M, Watanabe Y, Ando T, Higuchi S, Arinami T.
  • Journal Title: Synapse e-pub
  • Peer Reviewed
• [Journal Article] Replication study of association between ADCYAP1 gene polymorphisms and schizophrenia. (2010)
  • Author(s): Koga M, Ishiguro H, Horiuchi Y, Inada T, Ujike H, Itokawa M, Otowa T, Watanabe Y, Someya T, Arinami T.
  • Journal Title: Psychiatr Genet. 20(3) Pages: 123-125
  • Peer Reviewed
• [Journal Article] Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia (2010)
  • Author(s): Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ishikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T.
  • Journal Title: Neuropsychopharmacology. 35(5) Pages: 1155-1164
  • Peer Reviewed
• [Journal Article] Brain cannabinoid CB2 receptor in schizophrenia. (2010)
  • Author(s): Ishiguro H, Horiuchi Y, Ishikawa M, Koga M, Imai K, Suzuki Y, Morikawa M, Inada T, Watanabe Y, Takahashi M, Someya T, Ujike H, Iwata N, Ozaki N, Onaivi ES, Kunugi H, Sasaki T, Itokawa M, Arai M, Niizato K, Iritani S, Naka I, Ohashi J, Kakita A, Takahashi H, Nawa H, Arinami T.
  • Journal Title: Biol Psychiatry. 67(10) Pages: 974-982
  • Peer Reviewed
• [Journal Article] A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands. (2010)
  • Author(s): Ishiguro H, Carpio O, Horiuchi Y, Shu A, Higuchi S, Schanz N, Benno R, Arinami T, Onaivi ES
  • Journal Title: Synapse 64(1) Pages: 92-96
  • Peer Reviewed
• [Journal Article] Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia. (2009)
  • Author(s): Koga M, Ishiguro H, Yazaki S, Horiuchi Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Muchardt C, Yaniv M, Arinami T
  • Journal Title: Hum Mol Genet. 18(13) Pages: 2483-2494
  • Peer Reviewed
• [Presentation] ヒト、マウスモデルを用いたPDLIM5遺伝子の精神疾患の関連 (2010)
  • Author(s): 海東伸子
  • Organizer: 日本人類遺伝学会第55回大会
  • Place of Presentation: 大宮
  • Year and Date: 2010-10-30
• [Presentation] 薬原性遅発性ジスキネジアを表現型とした全ゲノム解析 (2010)
  • Author(s): 有波忠雄
  • Organizer: 2010日本臨床精神神経薬理学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-15
• [Presentation] Demeclin遺伝子と統合失調症との関連解析 (2009)
  • Author(s): 矢崎沙織
  • Organizer: 日本人類遺伝学会第54回大会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-26
• [Presentation] 薬原性遅発性ジスキネジアとHSPG2遺伝子との関連 (2009)
  • Author(s): 有波忠雄
  • Organizer: 日本人類遺伝学会第54回大会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-24
• [Remarks] ホームページ等
  • URL: http://www.md.tsukuba.ac.jp/basic-med/m-genetics/