2010 Fiscal Year Final Research Report
Survival mechanism of memory B cells
| Project/Area Number |
20390139
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Chiba University |
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Principal Investigator |
TOKUHISA Takeshi Chiba University, 大学院・医学研究院, 教授 (20134364)
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| Co-Investigator(Kenkyū-buntansha) |
HATANO Masahiko 千葉大学, 大学院・医学研究院, 教授 (20208523)
ARIMA Masafumi 千葉大学, 大学院・医学研究院, 講師 (00202763)
SAKAMOTO Akemi 千葉大学, 大学院・医学研究院, 助教 (90359597)
FUJIMURA Riza 千葉大学, バイオメディカル研究センター, 助教 (30376363)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 免疫記憶 / Bリンパ球 / 胚中心 / サイトカイン |
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| Research Abstract |
To elucidate differentiation mechanisms of memory B cells and long-lived plasma cells, we established the culture system to generate germinal center B cells. Using the system, we demonstrated that Bcl6 represses CD63 which recruits CXCR4 to late endosome to express CXCR4 on centroblasts and that the stimulation of plasmablasts with IL-21 generates long-lived plasma cells.
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Research Products
(32 results)
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[Journal Article] Outcome prediction in sepsis combined use of genetic polymorphisms- A study in Japanese population.2011
Author(s)
Shimada T, Oda S, Sadahiro T, Nakamura M, Hirayama Y, Watanabe E, Abe R, Nakada TA, Tateishi Y, Otani S, Hirasawa H, Tokuhisa T, Uno H
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Journal Title
Peer Reviewed
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[Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.2010
Author(s)
Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T
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Journal Title
J.Exp.Med. 207
Pages: 751-762
Peer Reviewed
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[Journal Article] IL-23 and Th17 cells enhance Th2 cell-mediated eosinophilic airway inflammation in mice.2008
Author(s)
Wakashin H, Hirose K, Maezawa Y, Kagami, S-I, Suto A, Watanabe N, Saito Y, Hatano M, Tokuhisa T, Iwakura Y, Puccetti P, Iwamoto I, Nakajima H
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Journal Title
Am.J.Resp.Crit Care Med. 178
Pages: 1023-1032
Peer Reviewed
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[Journal Article] Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A : T mutations.2008
Author(s)
Ouchida R, Ukai A, Mori H, Kawamura K, Dolle MET, Tagawa M, Sakamoto A, Tokuhisa T, Yokosuka T, Saito T, Yokoi M, Hanaoka F, Vijg J, Wang Ji-Y
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Journal Title
DNA Repair 7
Pages: 1392-1398
Peer Reviewed
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[Journal Article] A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3ζ degradation.2008
Author(s)
Ouchida R, Yamasaki S, Hikida M, Masuda K, Kawamura K, Wada A, Mochizuki S, Tagawa, M, Sakamoto A, Hatano M, Tokuhisa T, Koseki H, Saito T, Kurosaki T, Wang Ji-Y
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Journal Title
Peer Reviewed
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[Remarks] ホームページ等
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