2010 Fiscal Year Final Research Report
Molecular mechanisms for type I interferon production by Toll-like receptor-stimulated dendritic cells
| Project/Area Number |
20390146
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KAISHO Tsuneyasu The Institute of Physical and Chemical Research, 生体防御研究チーム, チームリーダー (60224325)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 樹状細胞 / Toll様受容体 / I型インターフェロン / シグナル伝達 / 樹状細胞サブセット / ケモカイン受容体 |
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| Research Abstract |
Dendritic cells (DCs) sense virus-or host-derived nucleic acids through Toll-like receptors (TLRs) and produce type I interferons (IFNs), thereby provoking antiviral host defense and causing manifestations of various autoimmune diseases. DCs consist of various subsets, but a serine threonine kinase, IKKα, was found to be a unique molecule involved in TLR-induced type I IFN production in all DC subsets. Importantly, we also found that IKK was important in human DCs as in murine DCs. We plan to further clarify molecular mechanisms for DC subset functions.
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[Presentation] 乳酸菌は樹状細胞エンドソーム内TLRを介してIFN-βを誘導する2009
Author(s)
T.Kawashima, R.Uchiyama, H.Tsutsui,(閻会敏Dong-Ju You or Myoung Ho Jang), T.Kaisho, T.Saito, I.Nishimura, N.Tsuji
Organizer
第39回日本免疫学会総会・学術集会記録39,181,2009
Place of Presentation
大阪国際会議場
Year and Date
20091202-20091204
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[Book] Principles of innate immunity, in Fifth Edition Rheumatology vol.1(edited by Marc C.Hochberg, Alan J.Silman, Josef S.Smolen, Michael E.Weinblatt. Michael H.Weisman)(1600 John F. Kennedy Boulevard, Suite 1800,Philadelphia,PA19103-2899,USA)2011
Author(s)
T.Kaisho, S.Akira
Total Pages
141-151
Publisher
MOSBY, ELSEVIER
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