G型肝炎ウイルス二重感染がHTLV-1母子感染に与える影響:後向きコホート研究

2009 Fiscal Year Annual Research Report

• Project/Area Number: 20390186
• Research Institution: Nagasaki University
• Principal Investigator: 山本 太郎 Nagasaki University, 熱帯医学研究所, 教授 (70304970)
• Co-Investigator(Kenkyū-buntansha): 市川 辰樹 長崎大学, 大学病院, 助教 (80346949) ; 矢野 公士 国立国際医療センター, 国府病院, 医長 (60360856) ; 片峰 茂 長崎大学, 学長 (40161062)
• Keywords: 疫学 / 感染症疫学

Research Abstract

本研究は、G型肝炎ウイルス(GB virus C:GBV-C/HGV)の二重感染が成人T細胞白血病ウイルス(Human T Lymphotropic Virus type 1:HTLV-1)の母子感染に与える影響を、後向きコホート研究によって評価する研究である。これまでに行われた研究から演繹される仮説として、我々は「GBV-C/HGVの二重感染がHTLV-1母子感染を抑制する可能性がある」との仮説を得た。一方、本研究はHTLV-1感染症を疫学的視点から深く理解することも同時に目指している。
当該年度は、HTLV-1抗体陽性妊婦保存血清のうち、出生児のHTLV-1感染の有無が、これまでに行われたHTLV-1母子感染防止事業より明らかな血清のリストを作成し、リストのなかから、無作為に抽出した血清に対しGBV-C/HGV感染率をRT-PCRを用いて計測し、妊婦集団におけるGBV-C/HGV感染率の推定を行った。HTLV-1陽性妊婦180名の検体を調査したところ、RT-PCRによる感染率は約2%と低率であることがわかった。次いで、得られた感染率より、GBV-C/HGV感染の有無によるHTLV-1母子感染率有意差検定に必要なサンプルサイズの推定を行ったところ、必要なサンプル数は約1000検体であることが明らかとなった。必要サンプル数は大きく、計画の変更が必要であることがわかった。そうした研究デザインの変更を行っている。一方、対象となった妊婦集団における抗体陽性率の経年推移や介入の結果に対する知見をまとめている。また、南西日本におけるHTLV-1の由来についても新たな知見を蓄積している。

Research Products

• [Journal Article] Educational intervention for preventing blood-borne infection among medical students in China. (2010)
  • Author(s): Zhang Z, Yamamoto T, Wu X, Moji K, Cai X, Kuroiwa C.
  • Journal Title: Journal of Hospital Infection. (in press)
• [Journal Article] A Further Insight into the Origin of Human T-Lymphotropic Virus Type 1(HTLV-1)in Japan, Based on the Genotyping of ABCC11. (2009)
  • Author(s): Oshima K, Fujii H, Eguchi K, Otani M, Matsuo T, Kondo S, Yoshiura K, Yamamoto T.
  • Journal Title: Tropical Medicine and Health. 37(3) Pages: 121-123
  • Peer Reviewed
• [Journal Article] Usefulness of Highly Active Antiretroviral Therapy on Health-Related Quality of Life of Adult Recipients in Tanzania. (2009)
  • Author(s): Magafu M, Moji K, Lgumvor EU, Hashizume M, Mizota T, Komazawa O, Cai G, Yamamoto T.
  • Journal Title: AIDS PATIENT CARE and STDs. 23(7) Pages: 563-570
  • Peer Reviewed
• [Journal Article] Effect of communal piped water supply on water use pattern and the transmission of schistosomiasis haematobia in an endemic area of Kenya. (2009)
  • Author(s): Abe M, Muhoho ND, Sunahara T, Moji K, Yamamoto T, Aoki Y.
  • Journal Title: Tropical Medicine and Health. 37(2) Pages: 43-53
  • Peer Reviewed
• [Journal Article] Human T-Lymphotropic Virus Type 1(HTLV-1)Genetic Typing in Kakeroma Island, an Island at the Crossroads of the Ryukyuans and Wajin in Japan, Providing Further Insights into the Origin of the Virus in Japan. (2009)
  • Author(s): Eguchi K, Fujii H, Otani M, Oshima K, Matsuo T, Yamamoto T.
  • Journal Title: Journal of Medical Virology 81 Pages: 1450-1456
  • Peer Reviewed
• [Journal Article] Risk Factors for Malaria Infection among Ethnic Minorities in Binh Phuoc, Vietnam. (2009)
  • Author(s): Abe T, Honda S, Nakazawa S, Tuong TD, Thieu NQ, Hung LX, Thuan LK, Moji K, Takagi M, Yamamoto T.
  • Journal Title: Southeast Asian Journal of Tropical Medicine and Public Health 40 Pages: 18-29
  • Peer Reviewed
• [Journal Article] Assessment of a questionnaire used for an AIDS-related KABP survey among physicians in China. (2009)
  • Author(s): Guoxi CAI, Jun KANG, Ling SHEN, Xiangdong MIN, Zhunyou WU, Keming ROU, Taro YAMAMOTO, Kazuhiko MOJI.
  • Journal Title: Information (in press)
  • Peer Reviewed
• [Journal Article] Study of liver-targeted regulatory T cells in hepatitis B and C virus in chronically infected patients. (2009)
  • Author(s): Miyaaki H, Zhou H, Ichikawa T, Nakao K, Shibata H, Takeshita S, Akiyama M, Ozawa E, Miuma S, Eguchi K
  • Journal Title: Liver Int 29(5) Pages: 702-707
  • Peer Reviewed
• [Journal Article] Long-term increase in liver volume after Denver peritoneovenous shunt : report of two cases. (2009)
  • Author(s): Miyaaki H, Murakami E, Ichikawa T, Nakao K, Takeshita S, Shibata H, Ozawa E, Akiyama M, Miuma S, Fujimoto M, Kuroki T, Tajima Y, Kanematsu T, Eguchi K
  • Journal Title: Liver Int 29(5) Pages: 774-775
  • Peer Reviewed
• [Journal Article] Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation. (2009)
  • Author(s): Eguchi S, Hidaka M, Tomonaga T, Miyazaki K, Inokuma T, Takatsuki M, Okudaira S, Yamanouchi K, Miyaaki H, Ichikawa T, Tajima Y, Kanematsu T
  • Journal Title: J Gastroenterol 44(6) Pages: 624-629
  • Peer Reviewed
• [Journal Article] Interferon-α-induced mTOR activation is an anti-hepatitis C virus signal via the phosphatidylinositol 3-kinase-Akt-independent pathway. (2009)
  • Author(s): Matsumoto A, Ichikawa T, Nakao K, Miyaaki H, Hirano K, Fujimoto M, Akiyama M, Miuma S, Ozawa E, Shibata H, Takeshita S, Yamasaki H, Ikeda M, Kato N, Eguchi K
  • Journal Title: J Gastroenterol 44(8) Pages: 856-863
  • Peer Reviewed
• [Journal Article] Predictive value of suppressor of cytokine signal 3(SOCS3)in the outcome of interferon therapy in chronic hepatitis C. (2009)
  • Author(s): Miyaaki H, Ichikawa T, Nakao K, Matsuzaki T, Muraoka T, Honda T, Takeshita S, Shibata H, Ozawa E, Akiyama M, Miuma S, Eguchi K
  • Journal Title: Hepatol Res 39(3) Pages: 850-855
  • Peer Reviewed
• [Journal Article] Hepatitis C virus kinetics during the first phase of pegylated interferon-α-2b with ribavirin therapy in patients with living donor liver transplantation. (2009)
  • Author(s): Ichikawa T, Nakao K, Miyaaki H, Eguchi S, Takatsuki M, Fujimoto M, Akiyama M, Miuma S, Ozawa E, Shibata H, Takeshita S, Kanematsu T, Eguchi K
  • Journal Title: Hepatol Res 39(9) Pages: 856-864
  • Peer Reviewed
• [Journal Article] The significance of enzyme immunoassay for the assessment of hepatitis Bvirus core-related antigen following liver transplantation. (2009)
  • Author(s): Fujimoto M, Ichikawa T, Nakao K, Miyaaki H, Shibata H, Eguchi S, Takatsuki M, Nagaoka S, Yatsuhashi H, Kanematsu T, Eguchi K
  • Journal Title: Intern Med 48(18) Pages: 1577-1583
  • Peer Reviewed
• [Journal Article] Induction of late-onset spontaneous autoimmune thyroiditis by a single low-dose irradiation in thyroiditis-prone non-obese diabetic-H2(h4)mice. (2009)
  • Author(s): Nagayama Y, Ichikawa T, Saitoh O, Abiru N
  • Journal Title: J Radiat Res 50(6) Pages: 573-577
  • Peer Reviewed
• [Journal Article] T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice. (2009)
  • Author(s): Horie I, Abiru N, Nagayama Y, Kuriya G, Saitoh O, Ichikawa T, Iwakura Y, Eguchi K
  • Journal Title: Endocrinology 150(11) Pages: 5135-5142
  • Peer Reviewed
• [Journal Article] The level of fasting serum insulin, but not adiponectin, is associated with the prognosis of early stage hepatocellular carcinoma. (2009)
  • Author(s): Miuma S, Ichikawa T, Taura N, Shibata H, Takeshita S, Akiyama M, Motoyoshi Y, Ozawa E, Fujimoto M, Kawashimo H, Miyaaki H, Eguchi K, Nakao K
  • Journal Title: Oncol Rep 22(6) Pages: 1415-1424
  • Peer Reviewed
• [Journal Article] Relationship between Regulatory T Cells and the Combination of Pegylated Interferon and Ribavirin for the Treatment of Chronic Hepatitis Type C. (2009)
  • Author(s): Akiyama M, Ichikawa T, Miyaaki H, Motoyoshi Y, Takeshita S, Ozawa E, Miuma S, Shibata H, Taura N, Nakao K
  • Journal Title: Intervirology 53(3) Pages: 154-160
  • Peer Reviewed
• [Journal Article] Serum BAFF and APRIL levels in patients with PBC. (2009)
  • Author(s): Migita K, Ilyassova B, Kovzel EF, Nersesov A, Abiru S, Maeda Y, Komori A, Ito M, Yano K, Yatsuhashi H, Shimoda S, Ishibashi H, Nakamura M.
  • Journal Title: Clin Immunol 134(2) Pages: 217-225
  • Peer Reviewed
• [Journal Article] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. (2009)
  • Author(s): Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, Ito Y, Mita E, Tanaka E, Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano K, Masaki N, Sugauchi F, Izumi N, Tokunaga K, Mizokami M.
  • Journal Title: Nat Genet 41(10) Pages: 1105-9
  • Peer Reviewed
• [Journal Article] Changing Epidemiology of Acute Hepatitis in Japan-Outbreaks of hepatitis E-. (2009)
  • Author(s): Yano K.
  • Journal Title: The 6th Korea-Japan Liver Symposium(KJLS), Kyong ju, Korea, 2009.07.19. Pages: 33-38
  • Peer Reviewed
• [Journal Article] Plasticity of intrahepatic biliary epithelial cells ; an alternative paradigm? (2009)
  • Author(s): Komori A, Fujiwara S, Aiba Y, Nakamura M, Yano K, Fujioka H, MIgita K, Ishibashi H.
  • Journal Title: International Symposium of Viral Hepatitis Research The Memorial Symposium for Professor Whan Kook Chung, Seoul, 2009.04.11. Pages: 38
  • Peer Reviewed
• [Journal Article] Analysis of Predicting factors for HBeAg-Ab seroconversion in chronichepatitis B patients. (2009)
  • Author(s): Sung-Kwan B, Yatsuhashi H, Yano K, Hamada R, Nakao R, Hashimoto S, Nishikawa A, Tateyama M, Motoyoshi Y, Nagaoka S, Taura N, Yanagi K, Abiru S, Ishibashi H.
  • Journal Title: International Symposium of Viral Hepatitis Research The Memorial Symposium for Professor Whan Kook Chung, Seoul, 2009.04.11. Pages: 20
  • Peer Reviewed
• [Journal Article] Emerging Infection of Hepatitis Viruses : Hepatitis E in Industrialized Countries. (2009)
  • Author(s): Yano K, Tamada Y, Yatsuhashi H, Komori A, Sung-Kwan B, Ishibashi H, Mishiro S, Mizokami M.
  • Journal Title: International Symposium of Viral Hepatitis Research The Memorial Symposium for Professor Whan Kook Chung, Seoul, 2009.04.11. Pages: 36
  • Peer Reviewed
• [Journal Article] 【ここが知りたいウイルス性肝炎への抗ウイルス療法の問題点と将来展望】B型肝炎急性肝炎への核酸アナログ投与の適応と中止基準. (2009)
  • Author(s): 八橋弘, 矢野公士, 長岡進矢, 阿比留正剛.
  • Journal Title: 肝・胆・膵 58(5) Pages: 601-608
  • Peer Reviewed
• [Journal Article] 【外科医が知っておくべきウイルス肝炎の最新治療】D, E型肝炎、その他のウイルス肝炎のupdate. (2009)
  • Author(s): 矢野公士.
  • Journal Title: 外科 71(4) Pages: 360-365
  • Peer Reviewed
• [Journal Article] ウイルス性急性肝炎の診断のポイントと盲点. (2009)
  • Author(s): 矢野公士.
  • Journal Title: Medical Practice 26(8) Pages: 1411
  • Peer Reviewed
• [Journal Article] A型肝炎 臨床. (2009)
  • Author(s): 矢野公士.
  • Journal Title: 臨床とウイルス 37(4) Pages: 291-295
  • Peer Reviewed
• [Presentation] How are micrornas working in esophageal squamous cell carcinoma? (2009)
  • Author(s): Matsushima K, Isomoto H, Inoue N, Norimura D, Nakashima Y, Yamaguchi N, Ohnita K, Ichikawa T, Takeshima F, Nakao K
  • Organizer: GASTRO 2009 UEGW/WCOG
  • Place of Presentation: Michael Farthing/Juan-R Maragelada London, United Kingdom
  • Year and Date: 20091121-20091125
• [Presentation] 東アジアにおける成人T細胞白血病ウイルス1型(HTLV-1)の空間的広がりと系統分化～HTLV-1がいつ、どこから日本に来て、どのように広まったのか～ (2009)
  • Author(s): 江口克之, 藤井秀文, 大島謙吾, 大谷正史, 松尾敏明, 渡邉俊樹, 山本太郎
  • Organizer: 第50回日本熱帯医学会大会
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 20091022-20091023
• [Presentation] Roles of growth hormone, insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in the development of non-alcoholic fatty liver disease (2009)
  • Author(s): Ichikawa T, Miyaaki H, Taura N, Nakao K
  • Organizer: Special Conference on NAFLD/NASH and Related Metabolic Disease
  • Place of Presentation: Bologna, Italy
  • Year and Date: 20090924-20090926
• [Remarks]
  • URL: http://www.tm.nagasaki-u.ac.jp/newrect/japanese/member/yamamoto.html