Disturbance of innate immune system in alcoholic sudden death and organ damage

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390196
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: MATSUMOTO Hiroshi 札幌医科大学, 医学部, 教授 (60263092)
• Project Period (FY): 2008 – 2010
• Keywords: アルコール / Myd88 / TLR / 自然免疫 / 急死 / 壊死

Research Abstract

This study found that the transcription factor IRF7 and its-induced IFNalpha plays a crucial role in the alcohol-related death, traumatic brain injury under alcohol consumption, and osteonecrosis of the femoral head

Research Products

• [Journal Article] アルコールの基礎知識 (2011)
  • Author(s): 松本博志
  • Journal Title: 日本アルコール・薬物医学会雑誌 Volume: 46 Pages: 135-140
• [Journal Article] 交通被害者と飲酒 (2011)
  • Author(s): 松本博志
  • Journal Title: 日本アルコール・薬物医学会雑誌 Volume: 46 Pages: 141-146
• [Journal Article] Prior ethanol injection promotes brain edema after traumatic brain injury : evidence for poor prognosis for intoxicated patients (2009)
  • Author(s): Katada R, Nishitani Y, Honmou O, Okazaki S, Houkin K, Matsumoto H
  • Journal Title: J Neurotrauma Volume: 26 Pages: 2015-2025
• [Journal Article] Femoral head osteonecrosis can be caused by disruption of the systemic immune response via the toll-like receptor 4 signalling pathway (2009)
  • Author(s): Okazaki S, Nishitani Y, Nagoya S, Kaya M, Yamashita T, Matsumoto H
  • Journal Title: Rheumatology Volume: 48 Pages: 227-232
• [Journal Article] Expression of aquaporin-4 augments cytotoxic brain edema after traumatic brain injury during acute ethanol exposure
  • Author(s): Katada R, Nishitani Y, Honmou O, Mizuo K, Okazaki S, Tateda K, Watanabe S, Matsumoto H
  • Journal Title: Am J Pathol Volume: (in press)
• [Journal Article] High risk of osteonecrosis of the femoral head in autoimmune disease patients showing no immediate increase in hepatic enzyme under steroid therapy
  • Author(s): Okazaki S, Nagoya S, Yamamoto M, Tateda K, Takahashi H, Yamashita T, Matsumoto H
  • Journal Title: Rheumatol Int Volume: (in press)
• [Presentation] Alcohol consumption promotes insulin resistance via accumulation of proinflammatory responses in the NIDDM murine model (2010)
  • Author(s): Matsumoto H, Tanaka M, Tateda K, Ishizaka A, Nishitani Y, Okazaki S, Katada R, Mizuo K, Watanab S
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U. S. A
  • Year and Date: 20100427-28
• [Presentation] Role of innate immune system of alcoholic liver disease and nonalcoholic fatty liver disease in forensic autopsy (2009)
  • Author(s): Matsumoto H, Tanaka M, Fujii K, Nishitani Y, Katada R, Ishizaka A, Shimizu J, Igarashi A, Hagiwara T, Tateda K, Mizuo K, Watanabe S
  • Organizer: XXI Congress of the International Academy of Legal Medicine
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 20090528-30
• [Presentation] TLR4-signaling pathway contributes to formation of steatosis in alcoholic and nonalcoholic fatty liver disease : A new therapy for fatty liver disease (2008)
  • Author(s): Matsumoto H, Fujii K, Nishitani Y, Okazaki S, Imabayashi K
  • Organizer: ISBRA 2008
  • Place of Presentation: Washington DC
  • Year and Date: 20080629-30
• [Book] NEW法医学・医事法 (2008)
  • Author(s): 松本博志
  • Total Pages: 95
  • Publisher: アルコールの法医学
• [Remarks]
  • URL: http://web.sapmed.ac.jp/legalm/