高脂肪食およびアディポネクチンが大腸がん発がんに与える作用の分子メカニズムの解析

2008 Fiscal Year Annual Research Report

• Project/Area Number: 20390212
• Research Institution: Yokohama City University
• Principal Investigator: 中島 淳 Yokohama City University, 附属病院, 教授 (30326037)
• Co-Investigator(Kenkyū-buntansha): 阿部 泰伸 横浜市立大学, 医学部, 助教 (10347312) ; 稲森 正彦 横浜市立大学, 医学部, 助教 (10381477) ; 高橋 宏和 横浜市立大学, 附属病院, 助教 (70438159)
• Keywords: 大腸がん / アディポネクチン / 高脂肪食 / 発癌機序

Research Abstract

近年先進国で大腸がん患者が急増しているがその危険因子として肥満、欧米食を主とした高脂肪食、運動不足などが明らかになってきた。今回の研究ではこのような危険因子が、実際どのような分子機序で大腸発がんを促進するのかを、肥満関連ホルモンの発がんへの作用を中心に解析を行った。平成20年度は肥満に伴い低下するアディポネクチンの大腸発がんへの影響に関して解析を行った。これまで疫学的には低アディポネクチン血症は大腸がんを促進することが知られているがその機序は不明であった。我々はマウス発がんモデルを用いてアディポネクチン欠損マウスとその野生型とで大腸発がんの比較を行ったところ、普通食では欠損マウス、野生型マウス両群間で差を認めなかったが、高脂肪食を投与した際にはじめてアディポネクチン欠損マウスで大腸ポリープの形成促進を有意に認めた。高脂肪条件下でアディポネクチン欠損マウスでは発がんが促進されたが、その機序解明のために大腸前がん病変と考えられているAberrant Crypt Foci(ACF)の形成および大腸上皮粘膜の上皮細胞の増殖促進の有無に関して検討したところ、マウスは高脂肪食摂取により、大腸上皮の増殖が促進され、前がん病変ACFの数も増加することが認められた。したがって高脂肪食条件では大腸上皮細胞の増殖が促進され、アディポネクチン欠損ではさらに促進され発がんが充進するものと考えられた。実際、アディポネクチン欠損マウスにアディポネクチンを連日注射して補充することで発がん抑制を確認できた。一方今回の結果の分子機序の解明のために大腸粘膜のリン酸化たんぱく質解析を行い、アディポネクチンはAMPKを活性化し、その下流にあるたんぱく質翻訳に関与するmTOR/S6Kシグナルを抑制することを明らかにした。本研究から大腸発がんにおけるアディポネクチンの役割と、分子機序解明され、今後はアディポネクチンの作用標的分子AMPKが新たな化学発がん予防の分子標的として重要な候補である可能性が示唆された。本研究は2008年Gutに掲載された。

Research Products

• [Journal Article] Adiponectin Suppresses Colorectal Carcinogenesis under the High-fat Diet Condition. (2008)
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• [Journal Article] Effectiveness of antlplatelet drugs on experimental non-alcoholic fatty liver disease. (2008)
  • Author(s): Fujita K, Nozaki Y, Yoneda M, Wada K, Endo H, Mawatari H, Takahashi H, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A.
  • Journal Title: Gut 57(11) Pages: 1583-91
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• [Journal Article] Novel role of IL-13 in fibrosis induced by Non-Alcoholic Steotohepatitis and its amelioration by IL-13 Receptor Directed Cytotoxin in a rat model. (2008)
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  • Journal Title: J Immunol 181(7) Pages: 4656-65
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• [Journal Article] Activation of peroxisome proliferator-activated receptorg suppresses mast cell maturation involved in allergic disease. (2008)
  • Author(s): Tachibana M, Wada K, Katayama K, Kamisaki Y, Maeyama K, Kadowaki, T, Blumberg RS, Nakajima A.
  • Journal Title: Allergy 63(9) Pages: 1136-47
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• [Journal Article] Tumorous arteriovenous malformation in the jejunum missed by capsule endoscopy. (2008)
  • Author(s): Endo H, Matsuhashi N, Inamori M, Ohya T, Yanagawa T, Asayama M, Hisatomi K, Teratani T, Fujita K, Yoneda M, Nakajima A.
  • Journal Title: Gastrointestinal Endoscopy 68(4) Pages: 773-4
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• [Journal Article] Gastric ulcer following a thrombotic aneurism of the splenic artery. (2008)
  • Author(s): Suzuki K, Takahashi H, Fujisawa N, Sekino Y, Akimoto K, Tomimoto A, Saito K, Yoneda M, Inamori M, Abe Y, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Koyama S, Nakajima A
  • Journal Title: Endoscopy 40 Suppl2 Pages: E193-4
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• [Journal Article] Tumor fragment impacted at the major duodenal papi11a causing obstructive jaundice in a patient with hepatocellular carcinoma (HCC). (2008)
  • Author(s): Kobayashi N, Kirikoshl H, Higurashi T, Iida H, Mawatari H, Endo H, Nozaki Y, Yoneda K, Akiyaraa T, Fujita K, Yoneda M, Takahashi H, Abe Y, Inamori M, Kubota K, Saito S, Ueno N, Nakajima A.
  • Journal Title: Gastrointestinal Endoscopy 68(5) Pages: 999-1000
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• [Journal Article] Differentiating Sclerosing Cholangitis Caused by Autoimmune Pancreatitis and Primary Sclerosing Cholangitis According to Endoscopic Duodenal Papillary Features. (2008)
  • Author(s): Kubota K, Kato S, Akiyama T, Yoneda M, Fujita K, Ogawa M, Inamori M, Kobayashi N, Saito S, Kakuta Y, Ohshiro H, Nakajima A.
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• [Journal Article] Inhibition of Peroxisome Proliferator-Actlvated Receptor Gamma Activity Suppresses Pancreatic Cancer Cell Motility. (2008)
  • Author(s): Nakajima A, Tomimoto A, Fujita K, Sugiyama M, Takahashi H, Ikeda I, Hosono K, Endo H, Yoneda K, Iida H, Inamori M, Kubota K, Saito S, Nakajima N, Wada K, Nagashima Y, Nakagama H.
  • Journal Title: Cancer Science 99(10) Pages: 1892-900
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• [Journal Article] Metformin suppresses intestinal polyp growth in ApcMin/+ mice. (2008)
  • Author(s): Tomimoto A, Endo H, Sugiyama M, Fujisawa T, Hosono K, Takahashi H, Nakajima N, Nagashima Y, Wada K, Nakagama H, Nakajima A.
  • Journal Title: Cancer Science 99(11) Pages: 2136-41
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• [Journal Article] Rebleeding rate after interventional therapy directed by capsule endoscopy in patients with obscure gastrointestinal bleeding. (2008)
  • Author(s): Endo H, Matsuhashi N, Inamori M, Akimoto K, Ohya T, Yanagawa T, Asayama M, Hisatomi K, Teratani T, Fujita K, Yoneda M, Nakajlma A.
  • Journal Title: BMC Gastroenterol 8(1) Pages: 12
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• [Journal Article] Collagenous colitis in Japanese woman : successful treatment by mesalazine. (2008)
  • Author(s): Suzuki K, Kawabe T, Takahashi H, Nakao S, Suzuki A, Inamori M, Iida H, Endo H, Akiyama T, Fujita K, Yoneda M, Abe Y, Kobayashi N, Kubota K, Oshiro H, Nakajima A.
  • Journal Title: Digestion 77(3-4) Pages: 155-156
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• [Journal Article] Ulcerative colitis with positivity for proteinase 3-antineutrophil cytoplasmic antibody. (2008)
  • Author(s): Suzuki K, Nakao S, Suzuki A, Inamori M, Iida H, Endo H, Akiyama T, Yoneda K, Fujita K, Takahashi H, Yoneda M, Abe Y, Kobayashi N, Kubota K, Saito S, Nakajima A.
  • Journal Title: Digestion 77(3-4) Pages: 157-158
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• [Journal Article] Association between PPARGCIA polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD). (2008)
  • Author(s): Yoneda M, Hotta K, Nozakl Y, Endo H, Uchiyama T, Mawatari H, Iida H, Kato K, Hosono K, Fujita K, Yoneda K, Takahashi H, Kirikoshi H, Kobayashi N, Inamori M, Abe Y, Kubota K, Saito S, Maeyama S, Wada K, Nakajima A.
  • Journal Title: BMC Gastroenterology 8 Pages: 27
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• [Journal Article] Severe large-intestine involvement in adult-onset Henoch-Schonlien purpura : Successful treatment with factor XIII concentrate. (2008)
  • Author(s): Hosono K, Endo H, Inamori M, Mawatari H, Iida H, Nozaki Y, Yoneda K, Akiyama T, Fujita K, Yoneda M, Takahashi H, Abe Y, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Nakajima A.
  • Journal Title: Digestion 78(1) Pages: 9
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• [Journal Article] Plasma Pentraxin3 is a Novel Marker for Nonalcoholic Steatohepatitis (NASH). (2008)
  • Author(s): Yoneda M, Uchiyama T, Kato S, Endo H, Fujita K, Yoneda K, Mawatari H, Iida H, Takahashi H, Klrikoshi H, Inamori M, Nozaki Y, Kobayashi N, Kubota K, Saito s, Maeyama S, Sagara M, Aburatani H, Kodama T, Nakajima A.
  • Journal Title: BMC Gastroenterol 8 Pages: 53
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• [Journal Article] Alcohol consumption is associated with an increased risk of erosive esophagitis and Barrett's epithelium in Japanese men. (2008)
  • Author(s): Akiyama T, Inamorl M, Iida H, Mawatari H, Endo H, Hosono K, Yoneda K, Fujita K, Yoneda M, Takahashi H, Goto A, Abe Y, Kobayashi N, Kubota K, Saito S, Nakajima A.
  • Journal Title: BMC Gastroenterol 8(1) Pages: 58
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• [Journal Article] Neither the presence of metabolic syndrome as defined by the IDF guideline nor an increased waist circumference increased the risk of microvascular or macrovascular complications in Japanese patients with type 2 diabetes. (2008)
  • Author(s): Iwasaki T, Togashi Y, Ohshige K, Yoneda M, Fujita K, Nakajima A, Terauchi Y
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• [Journal Article] Levovist ultrasonography imaging in intracystic hemorrhage of simple liver cyst. (2008)
  • Author(s): Akiyama T, Inamori M, Saito S, Takahashi H, Yoneda M, Fujita K, Fujisawa T, Abe Y, Kirikoshi H, Kubota K, Ueda M, Tanaka K, Togo S, Ueno N, Shimada H, Nakajima A
  • Journal Title: World J Gastroenterol 14(5) Pages: 805-7
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• [Journal Article] Acute appendicitis associated with Peutz-Jeghers-type hamartoma of the appendix. (2008)
  • Author(s): Iida H, Inamori M, Sekino Y, Endo H, Aklyama T, Fujita K, Takahashi H, Yoneda M, Kobayashi N, Abe Y, Kirikoshi H, Kubota K, Saito S, Oshiro H, Rino Y, Nakajma A.
  • Journal Title: Dig Dls Sci 53(10) Pages: 2832-3
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• [Journal Article] Characterization of K-ras Gene Mutations in Association with Mucinous Hypersecretion in Intraductal Papillary-Mucinous Neoplasms. (2008)
  • Author(s): Kobayashi N, Inamori M, Fujita K, Fujisawa T, Fujisawa N, Takahashi H, Yoneda M, Abe Y, Kawamura H, Shimamura T, Kirikoshl H, Kubota K, Sakaguchi T, Saito S, Saubermann LJ, Nakajima A.
  • Journal Title: J Hepatobiliary Pancreat Surg 15(2) Pages: 169-77
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• [Journal Article] Usefulness of multidetector computed tomography for detection of the obstructive point in a patient with ileus. (2008)
  • Author(s): Sakai E, Takahashi H, Inamori M, Endo H, Akiyama T, Akimoto K, Mawatari H, Nozaki Y, Fujita K, Yoneda M, Goto A, Abe Y, Kobayashi N, Kubota K, Saito S, Nakajima A.
  • Journal Title: Dig Dis Sci 53(12) Pages: 3264
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• [Journal Article] Colonic metastasis from hepatocellular carcinoma : manifested by gastrointestinal bleeding. (2008)
  • Author(s): Nozaki Y, Kobayashi N, Shimamura T, Akiyama T, Inamori M, Iida H, Endo H, Fujita K, Yoneda M, Takahashi H, Abe Y, Kirikoshi H, Kubota K, Saito S, Nakajima A.
  • Journal Title: Dig Dis Sci 53(12) Pages: 3265-6
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• [Journal Article] Antiphospholipid syndrome manifested by gastrointesitinal bleeding : Can we overlook endoscopically-revealed small lesions? (2008)
  • Author(s): Nakao S, Akimoto K, Inamori M, Suzuki A, Suzuki K, Iida H, Endo H, Akiyama T, Fujita K, Yoneda M, Takahashi H, Abe Y, Kobayashi N, Kubota K, Yamanaka S, Nakajima A.
  • Journal Title: Digestion 77(3-4) Pages: 139-140
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• [Journal Article] Ingesting 500 ml of Polyethylene Glycol Solution During Capsule Endoscopy Improves the Image Quality and Completion Rate to the Cecum. (2008)
  • Author(s): Endo H, Kondo Y, Inamori M, Ohya TR, Yanagawa T, Asayama M, Hisatomi K, Teratani T, Yoneda M, Nakajima A, Matsuhashi N.
  • Journal Title: Dig Dis Sci 53(12) Pages: 3201-5
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• [Journal Article] Reply to“High-sensitivity C-reactive protein and metabolic syndrome (insulin resistance syndrome)including nonalcoholic steatohepatitis". (2008)
  • Author(s): Yoneda M, Nozaki Y, Endo H, Fujita K, Nakajima A.
  • Journal Title: J Gastroenterol 43(4) Pages: 313
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• [Journal Article] Variations in the FTO gene are associated with severe obesity in the Japanese. (2008)
  • Author(s): Hotta K, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura Y.
  • Journal Title: J Hum Genet 53(6) Pages: 546-53
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• [Journal Article] Wada K, Nakagama H, Blumberg RS. PPARγ suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the b-catenin/TCF pathway. (2008)
  • Author(s): Nakajima A, Fujisawa T, Fujisawa N, Takahashi H, Ikeda I, Tomimoto A, Yonemitu K, Nakajima N
  • Journal Title: Journal of Pharmacological Science 106(4) Pages: 627-38
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• [Journal Article] Effective treatment for advanced hepatocellular carcinoma with portal venous invasion using a combination ther any of intra-arterial 5-fluorouracil and subcutaneous pegylated-interferon-alpha-2b. (2008)
  • Author(s): Mawatari H, Kirikoshi H, Yoneda M, Higurashi T, Fujita K, Saito S, Inamori M, Takahashi H, Abe Y, Kubota K, Nakajima A.
  • Journal Title: Hepato-Gastroenterology 55(86-87 Pages: 1776-7
  • Peer Reviewed
• [Journal Article] Sugimori K, Matuo K, Kazunaga T, Shimada H. Clinicopath ological study of resected cases with primary carcinoma of the cystic duct. (2008)
  • Author(s): Kubota K, Kakuta Y, Inayama Y, Yoneda M, Abe Y, Inamori M, Kirikoshi H, Saito S, Nakajima A
  • Journal Title: Hepato-Gastroenterology 55(85) Pages: 1174-8
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• [Journal Article] EDUCATION AND IMAGING Gastrointestinal : Intestinal spirochetosis. (2008)
  • Author(s): Tsuzawa K, Fujisawa N, Sekino Y, Suzuki K, Saito K, Koyama S, Tanaka M, Wada A, Inamori M, Kubota K, Nakajima A. O
  • Journal Title: J Gastroenterol Hepatol 23(7 Pt1) Pages: 116
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• [Journal Article] Gastric surgery is not a risk factor for the development or progression of Barrett's epithelium. (2008)
  • Author(s): Akiyama T, Inamori M, Akimoto K, Iida H, Mawatari H, Endo H, Nozaki Y, Yoneda K, Ikeda T, Sakamoto Y, Fujita K, Yoneda M, Takahashi H, Goto A, Hirokawa S, Abe Y, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Rino Y, Nakajima A.
  • Journal Title: Hepato-Gastroenterology 55(86-87) Pages: 1899-904
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• [Journal Article] Nitric oxide plays a crucial role in the development/progression of nonalcoholic steathepatitis (NASH)in the chollne deficient, 1-amino acid-deficient (CDAA)diet-fed rat model. [Epub a head of print] (2008)
  • Author(s): Fujita K, Nozaki Y, Yoneda M, Wada K, Takahashi H, Kirikoshi H, Inamori M, Saito s, Iwasakl T, Terauchi Y, Maeyama S, Nakajima A.
  • Journal Title: Alcohol Clin Exp Res (印刷中)
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• [Journal Article] Expression of Adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue. (2008)
  • Author(s): Yoneda K, Tomimoto A, Endo H, Iida H, Sugiyama M, Takahashi H, Nozaki Y, Fujita K, Yoneda M, Inamori M, Nakajima N, Wada K, Nagashlma Y, Nakagama H, Nakajima A.
  • Journal Title: Oncology Reports 20(3) Pages: 479-83
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• [Journal Article] Adenosequamous carcinoma of pancreas associated with Humoral Hypercalcemia of Malignancy (HHM). (2008)
  • Author(s): Kobayashi N, Higurashi T, Iida H, Mawatari H, Endo H, Nozaki Y, Tomimoto A, Yoneda K, Akiyama T, Fujita K, Takahashi H, Yoneda M, Abe Y, Kirikoshi H, Kubota K, Saito S, Ueno N, Nakajima A, Yamanaka S, Inayama Y.
  • Journal Title: J Hepatobiliary Pancreat Surg 15(5) Pages: 531-5
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• [Journal Article] Education and Imaging. Gastrointestinal : Ascaris lumbricoidosis manifested by gastrointesitinal bleeding. (2008)
  • Author(s): Suzuki A, Yabushita Y, Takahashi H, Inamori M, Nakao S, Suzuki K, Iida H, Endo H, Akiyama T, Ikeda T, Sakamoto Y, Fujita K, Yoneda M, Goto A, Abe Y, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Nakajima A.
  • Journal Title: J Gastroenterol Hepatol 23(11) Pages: 1770
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• [Journal Article] Gene Expression Profiling of Nonalcoholic Steatohepatitis (NASH) by Gene Set Enrichment Analysis (GSEA). (2008)
  • Author(s): Yoneda M, Endo H, Mawatari H, Nozaki Y, Fujita K, Akiyama T, Higurashi T, Uchiyama T, Yoneda K, Takahashi H, Kirikoshi H, Inamori M, Abe Y, Kubota K, Saito S, Kobayashi N, Yamaguchi N, Maeyama S, Yamamoto S, Tsutsumi S, Aburatani H, Wada K, Hotta K, Nakajima A.
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• [Journal Article] INSIG2 gene rs7566605 polymorphism is associated with severe obesity in the Japanese. (2008)
  • Author(s): Hotta K, Nakamura M, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura N.
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• [Journal Article] Aperitif effects on gastric emptying : a crossover study using continuous real time ^<13>C breath test (BreathID system). (2008)
  • Author(s): Inamori, M, Iida H, Endo H, Hosono K, Akiyama T, Yoneda K, Fujita K, Iwasaki H, Takahashi H, Yoneda M, Goto A, Abe Y, Kobayashi N, Kubota K, Nakajima A.
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• [Journal Article] Gastrointestinal : Aneurysmal artery in a gastric ulcer following endoscopic hemostasis. (2008)
  • Author(s): Abe Y, Inamori M, Uchiyama T, Iida H, Akimoto K, Mawatari H, Nozaki Y, Hosono K, Endo H, Akiyama T, Yoneda K, Fujita K, Yoneda M, Takahashi H, Goto A, Kobayashl N, Kirikoshi H, Kubota K, Saito S, Nakajima A.
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• [Journal Article] Chemotherapeutic treatment of priapism in metastatic rectal cancer. (2008)
  • Author(s): Kitai Y, Takahashi H, Goto A, Iida H, Mawatari H, Fujita K, Yoneda M, Inamori M, Abe Y, Kobayashl N, Kirikoshi H, Kubota K, Saito S, Nakajima A.
  • Journal Title: Case Reports in Gastroenterology 2 Pages: 505-508
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• [Journal Article] Gastric varices with remarkable collateral veins in valpronicacid induced chronic pancreatitis. (2008)
  • Author(s): Hattori Y, Higurashi T, Takahashi H, Inamori M, Abe Y, Rino Y, Nakajima A.
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• [Journal Article] Gastric inflammatory fibroid polyp treated by endoscopic submucosal dissection. (2008)
  • Author(s): Hattori Y, Kobayashl S, Takahashi H, Yoneda M, Inamori M, Abe Y, Kubota K, Saito S, Nakajima A.
  • Journal Title: Case Reports in Gastroenterology 2 Pages: 283-286
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• [Journal Article] Abdominal Surgery Affects Small Bowel Transit Time and Completeness of Capsule Endoscopy. (2008)
  • Author(s): Endo H, Matsuhashi N, Inamori M, Ohya T, Iida H, Mawatari H, Nozaki Y, Yoneda K, Akiyama T, Fujita K, Takahashi H, Yoneda M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
  • Journal Title: Dig Dis Sci 54(5) Pages: 1066-70
  • Peer Reviewed
• [Journal Article] Inhibition of peroxisome proliferator-activated receptorg promotes tumorigenesis through activation of the b-catenin/TCF pathway in the mouse intestine. (2008)
  • Author(s): Fujisawa T, Sugiyama M, Tomimoto A, Wada K, Endo H, Takahashi H, Yoneda K, Yoneda M, Inamori M, Saito S, Terauchi Y, Kadowaki T, Tsuchiya N, Nakagama H, Nakajima A.
  • Journal Title: J Parmacological Sci 108(4) Pages: 535-44
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• [Journal Article] Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction. (2008)
  • Author(s): Oshiro H, Matsuo K, Mawatari H, Inayama Y, Yamanaka S, Nagahama K, Endo I, Shimada H, Nakajima A, Kubota K.
  • Journal Title: Pathol Int 58(12) Pages: 780-6
  • Peer Reviewed
• [Journal Article] CEACAMl and the regulation of mucosal inflammation. (2008)
  • Author(s): Nagaishi T, Chen Z, Chen L, Iijima H, Nakajima A, Blumberg RS.
  • Journal Title: Mucosal Immunol 1 Supp11 Pages: S39-42
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• [Journal Article] Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor : a case report. (2008)
  • Author(s): Nakajima A, Takahashi H, Inamori M, Abe Y, Kobayashi N, Kubota K, Yamanaka S.
  • Journal Title: J Med Case Reports 2(1) Pages: 391
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• [Journal Article] Education and imaging. Gastrointestinal : mantle cell lymphoma diagnosed by balloon enteroscopy. (2008)
  • Author(s): Yumori A, Okubo H, Takahashi H, Iida H, Mawatari H, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A.
  • Journal Title: J Gastroenterol Hepatol 23(10) Pages: 1623
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• [Journal Article] Risk Factors for the Progression of Endoscopic Barrett's Epithelium in Japan : A Multivariate Analysis Based on The Prague C & M Criteria. [Epub ahead of print] (2008)
  • Author(s): Akiyama T, Inamori M, Akimoto K, Iida H, Mawatari H, Endo H, Ikeda T, Nozaki Y, Yoneda K, Sakamoto Y, Fujita K, Yoneda M, Takahashi H, Hirokawa S, Goto A, Abe Y, Klrikoshi H, Kobayashi N, Kubota K, Saito S, Nakajima A
  • Journal Title: Dig Dis Sci (印刷中)
  • Peer Reviewed
• [Journal Article] Association of visceral fat accumulation and plasma adiponectin with rectal dysplastic aberrant crypt foci in a clinical population. (2008)
  • Author(s): Takahashi H, Takayama T, Yoneda K, Endo H, Iida H, Sugiyama M, Fujita K, Yoneda M, Inamori M, Abe Y, Saito S, Wada K, Nakagama H, Nakajima A
  • Journal Title: Cancer Sci 100(1) Pages: 29-32
  • Peer Reviewed
• [Journal Article] Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD). (2008)
  • Author(s): Yoneda M, Yoneda M, Mawatari H, Fujita K, Endo H, Iida H, Nozaki Y, Yonemitsu K, Higurashi T, Takahashi H, Kobayashi N, Kirikoshi H, Abe Y, Inamori M, Kubota K, Saito S, Tamano M, Hiraishi H, Maeyama S, Yamaguchi N, Togo S, Nakajima A
  • Journal Title: Dig Liver Dis 40(5) Pages: 371-8
  • Peer Reviewed
• [Presentation] Novel diagnostic approach for NASH using [11c] choline dynamic PET imaging (2008)
  • Author(s): Fujita K, Nozaki Y, Yoneda M, Hosono K, Endo H, Takahashi H, Inamori M, Abe Y, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Nakajima A
  • Organizer: 2008 16^<th> UEGW Oral presentation
  • Place of Presentation: Vienna Austria
  • Year and Date: 20081018-20081022
• [Presentation] Role of inducible nitric oxide synthase in experimental nonalcoholic steatohepatitis (NASH)model. (2008)
  • Author(s): Nozaki Y, Fujita K, Yoneda M, Takahashi H, Kirikoshi H, Abe Y, Kobayashi N, Inamori M, Kubota K, Saito S, Nakajima A
  • Organizer: 16^<th> United European Gastroenterology Week (UEGW) Oral presentation
  • Place of Presentation: Vienna Austria
  • Year and Date: 20081018-20081022
• [Presentation] Correlation of the plasma level of insulin-like growth factor-l with the number of aberrant crypt foci in men. Poster sessions Lower GI (2008)
  • Author(s): Takahashi H, Hosono K, Endo H, Yoneda K, Mawatari H, Fujita K, Yoneda M, Abe Y, Inamori M, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
  • Organizer: 16^<th> United European Gastroenterology Week (UEGW)
  • Place of Presentation: Vienna Austria
  • Year and Date: 20081018-20081022
• [Presentation] Abdominal surgery affects small bowel transit time and completeness of capsule endoscopy. (2008)
  • Author(s): Hosono K, Endo H, Inamori M, Yoneda K, Akiyama T, Abe Y, Matsuhashi N, Nakajima A
  • Organizer: 16^<th> United European Gastroenterology Week (UEGW) Poster sessions : endoscopy
  • Place of Presentation: Vienna Austria
  • Year and Date: 20081018-20081022
• [Presentation] Predictive factors of spontaneous remission, relapse and developing cancer in cases of autoimmune pancreatitis. (2008)
  • Author(s): Kubota K, Kato S, Ogawa M, Inamori M, Kobayashi N, Nakajima A
  • Organizer: 16^<th> United European Gastroenterology Week (UEGW) Oral presentation Pancreatic potpourrioral presentation
  • Place of Presentation: Vienna Austria
  • Year and Date: 20081018-20081022
• [Presentation] Gastric Surgery Is Not a Risk Factor for the Development or Progression of Barrett's Epithelium. (2008)
  • Author(s): Akiyama T, Inamori M, Nakajima A
  • Organizer: Poster Session. The 11^<th> World Congress of the International Society for Disease of the Esophagus
  • Place of Presentation: Budapest
  • Year and Date: 20080910-20080913
• [Presentation] Comparative study of the Convenience of the QUEST and FSSG Questionnaires. Poster Session. (2008)
  • Author(s): Inamori M, Akiyama T, Nakajima A
  • Organizer: 11^<th> World Congress of the International Society for the Diseases of the Esophagus
  • Place of Presentation: Budapest
  • Year and Date: 20080910-20080913
• [Presentation] The comparison of the trans-arterial cherao-embolization (TACE) monotherapy and the combined TACE with percutaneous local the rapy for Hepatocellular carcinoma (HCC). (2008)
  • Author(s): Kirikoshi H, Saito S, Yoneda M, Fujita K, Mawatari H, Nozaki Y, Uchiyama T, Ikeda T, Hosono K, Akiyama T, Endo H, Yoneda K, Inamori M, Takahashi H, Iida H, Kato S, Abe Y, Kobayashi N, Kubota K, Nakajima A
  • Organizer: 59^<th> Annual Meeting of the American Association for the study of Liver Diseases (AASLD). Poster presentation
  • Place of Presentation: San Francisco
  • Year and Date: 2008-11-02
• [Presentation] Influence of AGTRl polymorphisms in Japanese patients with nonalcoholic fatty liver disease (NAFLD). (2008)
  • Author(s): Yoneda M, Nozaki Y, Hotta K, Mawatari H, Iida H, Uchiyama T, Yoneda K, Endo H, Kato S, Hosono K, Fujita K, Higurashi T, Kirikoshi H, Kubota K, Kobayashi N, Inamori M, Saito S, Nakajima A
  • Organizer: AASLD 2008 Annual Meeting
  • Place of Presentation: San Francisco
  • Year and Date: 2008-11-02
• [Presentation] Effect of ezetimibe administered in combination with acarbose against the development of nonalcoholic fatty liver disease (N AFLD). (2008)
  • Author(s): Nozaki Y, Fujita K, Yoneda M, Kato S, Uchiyama T, Iida H, Mawatari H, Hosono K, Endo H, Akiyama T, Yoneda K, Takahashi H, Kirikoshi H, Kobayashi N, Abe Y, Inamori M, Kubota K, Saito S, Nakajima A
  • Organizer: 59^<th> Annual Meeting of the American Association for the study of Liver Diseases (AASLD). Poster presentation
  • Place of Presentation: San Francisco
  • Year and Date: 2008-11-02
• [Presentation] Alcohol consumption is associated with an increased risk of erosive esophagitis and Barrett's epithelium in Japanese men. (2008)
  • Author(s): Akiyama T, Inamori M, Fujita K, Yoneda M, Nakajima A
  • Organizer: The second United States-Japan joint workshop on alcolol-related problems
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-17
• [Presentation] Endoscopic ultrasound pays dividends in the diagnosis of early autoimmune pancreatitis. (2008)
  • Author(s): Kubota K, Kato S, Ogawa M, Kobayashi N, Nakajima A
  • Organizer: 2008 16^<th> International Symposium on Endoscopic Ultrasound Poster Session
  • Place of Presentation: Sanfransisco
  • Year and Date: 2008-09-12
• [Presentation] Metformin suppresses the oolorectal carcinogenesis via activating AMP protein kinase. (2008)
  • Author(s): Suzuki K, Endo H, Kato S, Uchiyama T, Iida H, Mawatari H, Takahashi H, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
  • Organizer: 2008 DDW
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-21
• [Presentation] Sclerosing Cholangitis Affecting the Hilar Bile Duct is Associated with a Cancer Risk in Cases with Autoimmune Pancreatiis. (2008)
  • Author(s): Kubota K, Inamori M, Mawatari H, Nakajima A
  • Organizer: 2008 DIGESTIVE DISEASE WEEK Poster Session-CLINICAL
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-21
• [Presentation] Endoscopic Duodenal Papillary Features in Cases of Sclerosing Cholangitis Caused By Autoimmune Pancreatitis Differentiated from Those in Cases of Primry Sclerosing Cholagitis. (2008)
  • Author(s): Kubota K, Mawatari H, Nakajima A
  • Organizer: 2008 DIGESTIVE DISEASE WEEK Poster Session-CLINICAL
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-21
• [Presentation] Three clinicopathological Subtypes of Autoimmune Pancreatitis Stratified By the Duodenal Papillary Findings and the Serum IgG4. (2008)
  • Author(s): Kubota K, Inamori M, Nakajima A
  • Organizer: 2008 DIGESTIVE DISEASE WEEK Poster Session-CLINICAL
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-21
• [Presentation] Association Between Ppargcla Polymorphisms and the Occurrence of Nonalcoholic Fatty Liver Disease(NAFLD) (2008)
  • Author(s): Yoneda M, Fujita K, Nozaki Y, Kirikoshi H, Nakajima A
  • Organizer: 2008 DIGESTIVE DISEASE WEEK Poster Session-COMBINED
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-18
• [Presentation] Adiponectin suppresses colorectal carcinogenesis induced by high-fat diet via AMP protein kinase. (2008)
  • Author(s): Fujisawa N, Takahashi H, Hosono K, Shinohara Y, Sugiyama M, Endo H, Nozaki Y, Akiyama T, Yoneda K, Fujita K, Yoneda M, Nakajima A
  • Organizer: 2008 DDW
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-18
• [Presentation] Visceral fat obesity and abnormal glucose tolerance correlate with dysplastic aberrant crypt foci in colorectal tumor free male. (2008)
  • Author(s): Takahashi H, Yoneda K, Endo H, Iida H, Akiyama T, Abe Y, Inamori M, Nakajima A
  • Organizer: 2008 DDW
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-18
• [Presentation] Feasibility of Percutaneous Transhiepato-Cholecystic Biliary Interventions After Failed Endoscopic Attempt. (2008)
  • Author(s): Kubota K, Inamori M, Nakajima A
  • Organizer: 2008 DIGESTIVE DISEASE WEEK Poster Session-CLINICAL
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-18
• [Presentation] Novel Diagnostic Approach for NASH Using[11c]Choline Dynamic PET Imaging. (2008)
  • Author(s): Fujita K, Nozaki Y, Yoneda M, Kirikoshi H, Inamori M, Kubota K, Saito S, Nakajima A
  • Organizer: 2008 DIGESTIVE DISEASE WEEK Poster Session-COMBINED
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-18