2010 Fiscal Year Final Research Report
Mechanisms of host defense against pulmonaryinfection, inflammation and injury by surfactant proteins and studies on clinical applications
| Project/Area Number |
20390232
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KUROKI Yoshio Sapporo Medical University, 医学部, 教授 (70161784)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Motoko 札幌医科大学, 医学部, 准教授 (00303941)
SHIMIZU Takeyuki 札幌医科大学, 医学部, 講師 (10339137)
NISHITANI Chiaki 札幌医科大学, 医学部, 助教 (30381255)
ARIKI Shigeru 札幌医科大学, 医学部, 助教 (80464478)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肺サーファクタント蛋白質 / 肺胞マクロファージ / 肺胞II型細胞 / レジオネラ菌 / 非定型抗酸菌 / マトリックスメタロプロテアーゼ |
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| Research Abstract |
Pulmonary surfactant is composed of lipids and proteins, and plays important roles in alveolar stability and in host defense of respiratory system. In this study, we made specific antibody against human SP-C, which can be used for clinical applications. In addition, SP-A and SP-D, pulmonary collectins, have been shown to directly bind to Legionella pneumophila and Mycobacterium avium, suppress their growth and inhibit cellular injuries caused by these bacteria. SP-D has been found to inhibit matrix metallo-proteinase activity in alveolar macrophages, These results established the molecular bases for clinical applications of the uses of surfactant proteins.
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[Journal Article] Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth.2010
Author(s)
Sawada K, Ariki S, Kojima T, Saito A, Yamazoe M, Nishitani C, Shimizu T, Takahashi M, Mitsuzawa H, Yokota SI, Sawada N, Fujii N, Takahashi H, Kuroki Y.
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Journal Title
J Biol Chem vol285
Pages: 8434-8443
Peer Reviewed
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[Journal Article] Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells.2009
Author(s)
Osumi D, Takahashi M, Miyoshi E, Yokoe S, Lee SH, Noda K, Nakamori S, Gu J, Ikeda Y, Kuroki Y, Sengoku K, Ishikawa M, Taniguchi N.
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Journal Title
Cancer Sci vol100
Pages: 888-895
Peer Reviewed
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[Journal Article] Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain.2008
Author(s)
Nie X, Nishitani C, Yamazoe M, Ariki S, Takahashi M, Shimizu T, Mitsuzawa H, Sawada K, Smith K, Crouch E, Nagae H, Takahashi H, Kuroki Y.
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Journal Title
Biochemistry vol47
Pages: 12873-12855
Peer Reviewed
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[Journal Article] Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors.2008
Author(s)
Yamazoe M, Nishitani C, Takahashi M, Katoh T, Ariki S, Shimizu T, Mitsuzawa H, Sawada K, Voelker DR, Takahashi H, Kuroki Y.
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Journal Title
J Biol Chem vol283
Pages: 35878-35888
Peer Reviewed
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