2010 Fiscal Year Final Research Report
Molecular mechanism of adipose tissue remodeling and lipotoxicity
| Project/Area Number |
20390261
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OGAWA Yoshihiro Tokyo Medical and Dental University, 難治疾患研究所, 教授 (70291424)
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| Co-Investigator(Renkei-kenkyūsha) |
YASUDA Kazuki 独立行政法人国立国際医療研究センター, 研究所, 部長 (80311611)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脂肪組織 / マクロファージ / 炎症 / 肥満 / 遊離脂肪酸 |
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| Research Abstract |
Evidence has accumulated indicating that obesity is associated with a state of chronic, low-grade inflammation, suggesting that inflammation may be a potential mechanism, whereby obesity leads to the metabolic syndrome. We have demonstrated that the crosstalk between adipocytes and macrophages may aggravate obesity-induced adipose tissue inflammation. In this study, we provided evidence on the novel molecular mechanisms underlying the inflammatory changes in hypertrophied adipocytes and adipose tissue macrophages, which may lead to novel therapeutic strategies to prevent or treat the metabolic syndrome.
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Research Products
(36 results)
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[Journal Article] Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages.2010
Author(s)
K.Yamashiro, T.Sasano, K.Tojo, I.Namekata, J.Kurokawa, N.Sawada, T.Suganami, Y.Kamei, H.Tanaka, N.Tajima, K.Utsunomiya, Y.Ogawa, T.Furukawa.
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Journal Title
Biochem.Biophys.Res.Commun. 398
Pages: 284-289
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[Journal Article] Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/Toll-like receptor 4 signaling and macrophage activation in obese adipose tissue.2009
Author(s)
T.Suganami, X.Yuan, Y.Shimoda, K.Uchio-Yamada, N.Nakagawa, I.Shirakawa, T.Usami, T.Tsukahara, K.Nakayama, Y.Miyamoto, K.Yasuda, J.Matsuda, Y.Kamei, S.Kitajima, Y.Ogawa.
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Journal Title
Circ.Res. 105
Pages: 25-32
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[Journal Article] for the Japan Obesity and Metabolic Syndrome Study (JOMS) Group.Evaluation of the cardio-ankle vascular index, a new indicator of arterial stiffness independent of blood pressure, in obesity and metabolic syndrome.2008
Author(s)
N.Satoh, A.Shimatsu, Y.Kato, R.Araki, K.Koyama, T.Okajima, M.Tanabe, M.Ooishi, K.Kotani, Y.Ogawa
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Journal Title
Hypertens.Res. 31
Pages: 1921-1930
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[Journal Article] In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid.2008
Author(s)
H.Yamada, M.Yoshida, Y.Nakano, T.Suganami, N.Satoh, T.Mita, K.Azuma, M.Itoh, Y.Yamamoto, Y.Kamei, M.Horie, H.Watada, Y.Ogawa.
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Journal Title
Arterioscler.Thromb.Vasc.Biol. 28
Pages: 2173-2179
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[Journal Article] Role of C-C chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue.2008
Author(s)
A.Ito, T.Suganami, A.Yamauchi, M.Degawa-Yamauchi, M.Tanaka, R.Kouyama, Y.Kobayashi, N.Nitta, K.Yasuda, Y.Hirata, W.A.Kuziel, M.Takeya, S.Kanegasaki, Y.Kamei, Y.Ogawa.
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Journal Title
J.Biol.Chem. 283
Pages: 35715-35723
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[Presentation] Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/TLR4 signaling and macrophage activation in obese adipose tissue.2010
Author(s)
T.Suganami, X.Yuan, Y.Shimoda, N.Nakagawa, I.Shirakawa, Y.Miyamoto, K.Yasuda, Y.Kamei, S.Kitajima, Y.Ogawa
Organizer
14th International Congress of Endocrinology.
Place of Presentation
Kyoto, Japan.
Year and Date
20100326-20100330
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