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2010 Fiscal Year Final Research Report

Development of disease specific novel therapeutic strategy of pediatric solid tumors based on the molecular pathogenesis

Research Project

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Project/Area Number 20390292
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionThe University of Tokyo

Principal Investigator

TAKITA Junko  The University of Tokyo, 医学部附属病院, 講師 (00359621)

Co-Investigator(Kenkyū-buntansha) NANYA Yasuhito  東京大学, 医学部附属病院, 助教 (60451811)
Project Period (FY) 2008 – 2010
Keywords小児悪性腫瘍 / 神経芽腫 / Ewing肉腫 / 横紋筋肉腫 / ALK遺伝子 / SNPアレイ
Research Abstract

To explore molecular pathogenesis and identify therapeutic gene targets of pediatric solid tumors, we performed genome-wide copy number analysis of 419 pediatric solid tumors using SNP-genotype microarrays. High-grade amplifications of 2p23 involving ALK locus were identified in several neuroblastoma cases. Of note, oncogenic mutations of ALK were also found in approximately 6% of fresh tumors and 30% of cell lines. Thus, our findings implicate that ALK is one of the gene targets of neuroblastoma and have potential as tractable targets for this intractable disease.

  • Research Products

    (32 results)

All 2011 2010 2009 2008 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (10 results) Book (3 results)

  • [Journal Article] Oncogenic mutations of ALK in neuroblastoma.2011

    • Author(s)
      Ogawa S, Takita J, Sanada M, Hayashi Y.
    • Journal Title

      Cancer Sci. 102

      Pages: 302-308

    • Peer Reviewed
  • [Journal Article] IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies.2011

    • Author(s)
      Oki K, Takita J, Hiwatari M, 他9名
    • Journal Title

      Leukemia. 25

      Pages: 382-384

    • Peer Reviewed
  • [Journal Article] Oncogenic mutations of ALK in neuroblastoma.2011

    • Author(s)
      Ogawa S, Takita J, 他2名
    • Journal Title

      Cancer Sci. 102

      Pages: 302-308

    • Peer Reviewed
  • [Journal Article] A nonsense mutation of IDH1 in myelodysplastic syndromes and related disorders.2011

    • Author(s)
      Yoshida K, Sanada M, Kato M, Kawahata R, Matsubara A, Takita J, 他4名
    • Journal Title

      Leukemia. 25

      Pages: 184-186

    • Peer Reviewed
  • [Journal Article] Interstitial deletion of 13q14.13-q32.3 presenting with Arima syndrome and bilateral retinoblastoma.2011

    • Author(s)
      Takahashi K, Oka A, Mizuguchi M, Saitoh M, Takita J, 他5名.
    • Journal Title

      Brain Dev. 33

      Pages: 353-356

    • Peer Reviewed
  • [Journal Article] Expression of ADAMTS4 in Ewing's sarcoma.2010

    • Author(s)
      Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, 他7名
    • Journal Title

      Int J Oncol. 37

      Pages: 569-581

    • Peer Reviewed
  • [Journal Article] Sustained cytokinemia and chemokinemia concomitant with juvenile myelomonocytic leukemia in an infant with Noonan syndrome.2010

    • Author(s)
      Okazaki K, Unemoto J, Kondo M, Kusaka T, Kozawa K, Yoshizumi M, Shimada A, Takita J, 他3名
    • Journal Title

      Leuk Res. 34

      Pages: e226-e228

    • Peer Reviewed
  • [Journal Article] Comprehensive genetic analysis of overlapping syndromes of RAS/RAF/MEK/ERK pathway.2010

    • Author(s)
      Tumurkhuu M, Saitoh M, Sato A, Takahashi K, Mimaki M, Takita J, 他4名
    • Journal Title

      Pediatr Int. 52

      Pages: 557-562

    • Peer Reviewed
  • [Journal Article] Voriconazole-micafungin combination therapy for acute lymphoblastic leukemia.2010

    • Author(s)
      Okamoto T, Koh K.Takita J, Ida K
    • Journal Title

      Pediatr Int. 52

      Pages: 137-141

    • Peer Reviewed
  • [Journal Article] Hepatoblastoma in a patient with sotos syndrome.2009

    • Author(s)
      Kato M, Takita J, 他9名
    • Journal Title

      J Pediatr. 155

      Pages: 937-939

    • Peer Reviewed
  • [Journal Article] Japan Marrow Donation Program (JMDP). Exploration of the genetic basis of GVHD by genetic association studies.2009

    • Author(s)
      Ogawa S, Matsubara A, Onizuka M, Kashiwase K, Sanada M, Kato M, Nannya Y, Akatsuka Y, Satake M, Takita J, 他7名
    • Journal Title

      Biol Blood Marrow Transplant. 15(1 Suppl)

      Pages: 39-41

    • Peer Reviewed
  • [Journal Article] Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.2009

    • Author(s)
      Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, 他16名
    • Journal Title

      Nature. 460

      Pages: 904-908

    • Peer Reviewed
  • [Journal Article] Acute megakaryoblastic leukemia in a child with the MLL-AF4 fusion gene.2009

    • Author(s)
      Takita J, Motomura A, 他5名
    • Journal Title

      Eur J Haematol. 83

      Pages: 149-153

    • Peer Reviewed
  • [Journal Article] Frequent inactivation of A20 in B-cell lymphomas.2009

    • Author(s)
      Kato M, Sanada M, Kato I, Sato Y, Takita J, 他24名
    • Journal Title

      Nature. 459

      Pages: 712-716

    • Peer Reviewed
  • [Journal Article] Japan Marrow Donor Program.Possible association between obesity and posttransplantation complications including infectious diseases and acute graft-versus-host disease.2009

    • Author(s)
      Fuji S, Kim SW, Yoshimura K, Akiyama H, Okamoto S, Sao H, Takita J, 他2名
    • Journal Title

      Biol Blood Marrow Transplant. 15

      Pages: 73-82

    • Peer Reviewed
  • [Journal Article] Oncogenic mutations of ALK kinase in neuroblastoma.2008

    • Author(s)
      Takita J(*co-1st authors) Chen Y, Choi YL, 他11名
    • Journal Title

      Nature. 455

      Pages: 971-974

    • Peer Reviewed
  • [Journal Article] A complex t(1;22;11)(q44;q13;q23) translocation causing MLL-p300 fusion gene in therapy-related acute myeloid leukemia.2008

    • Author(s)
      Ohnishi H, Taki T, Yoshino H, Takita J, 他7名
    • Journal Title

      Eur J Haematol. 81

      Pages: 475-480

    • Peer Reviewed
  • [Journal Article] Whole-genome profiling of chromosomal aberrations in hepatoblastoma using high-density single-nucleotide polymorphism genotyping microarrays.2008

    • Author(s)
      Suzuki M, Kato M, Yuyan C, Takita J, 他8名
    • Journal Title

      Cancer Sci. 99

      Pages: 564-570

    • Peer Reviewed
  • [Journal Article] Imaging findings of upper abdominal involvement by acute megakaryoblastic leukaemia.2008

    • Author(s)
      Amemiya S, Akahane M, Takita J, 他2名
    • Journal Title

      Pediatr Radiol. 38

      Pages: 457-461

    • Peer Reviewed
  • [Presentation] 小児固形腫瘍におけるALK遺伝子の関与2010

    • Author(s)
      滝田順子, 西村力, 大木健太郎, 樋渡光輝, 大久保淳, 内坂直樹, 真田昌, 大喜多肇, 藤本純一郎, 金兼弘和, 五十嵐隆, 林泰秀, 小川誠司
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      20100922-20100924
  • [Presentation] Effects of selective ALK inhibitors to neuroblastoma2010

    • Author(s)
      Takita J, Okubo J, Nishimura R, Oki K, Uchisaka N, Chen Y, Sanada M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S
    • Organizer
      Advances in Neuroblastoma Research
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      20100621-20100624
  • [Presentation] Ewing/PNET family におけるALK遺伝子の解析2010

    • Author(s)
      滝田順子, 西村力, 大木健太郎, 金兼弘和, 大喜多肇, 藤本純一郎, 菊地陽, 林泰秀, 五十嵐隆, 小川誠司
    • Organizer
      第113回日本小児科学会学術集会
    • Place of Presentation
      岩手
    • Year and Date
      20100423-20100425
  • [Presentation] ALK gene aberrations in pediatric solid tumors.2010

    • Author(s)
      Takita J, Nishimura R, Sanada M, Ohki K, Kato M, ChenY, Kanegane H, Okita H, Fujimoto J, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S
    • Organizer
      The 6th Congress of Asian Society for Pediatric Research & 51st Annual Meeting of Taiwan Pediatric Association
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      20100415-20100418
  • [Presentation] 小児固形腫瘍におけるALK遺伝子の解析2009

    • Author(s)
      滝田順子, 西村力, 大木健太郎, 陳玉彦, 加藤元博, 真田昌, 金兼弘和, 大喜多肇, 藤本純一郎, 菊地陽, 五十嵐隆, 林康秀, 小川誠司
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20091209-20091212
  • [Presentation] 小児固形腫瘍におけるALK遺伝子の増幅と変異2009

    • Author(s)
      滝田順子, 大木健太郎, 西村力, 加藤元博, 陳玉彦, 真田昌, 金兼弘和, 大喜多肇, 藤本純一郎, 菊地陽, 五十嵐隆, 林康秀, 小川誠司
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      20091001-20091003
  • [Presentation] 神経芽腫におけるALK遺伝子の解析2009

    • Author(s)
      滝田順子, 陳玉彦, 加藤元博, 大平美紀, 菊地陽, 中川原章, 間野博行, 林泰秀, 五十嵐隆, 小川誠司
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良
    • Year and Date
      20090417-20090419
  • [Presentation] 横紋筋肉腫における網羅的ゲノム解析2008

    • Author(s)
      滝田順子, 陳玉彦, 加藤元博, 山本豪, 南谷泰仁, 真田昌, 菊地陽, 小川誠司, 林泰秀, 五十嵐隆
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      20081028-20081030
  • [Presentation] 超高密度SNPアレイを用いたMLL再構成陽性小児白血病におけるmolecular allelo-karyotyping2008

    • Author(s)
      滝田順子, 加藤元博, 陳玉彦, 大木健太郎, 山本豪真田昌, 南谷泰仁, 滝智彦, 五十嵐隆, 林康秀, 小川誠司
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      20081010-20081012
  • [Presentation] High-Resolution Copy Number Analysis and Identification of Target Genes in Neuroblastoma Using High-Density SNP-genotyping Microarrays.2008

    • Author(s)
      Takita J, Chen Y, Kato M, Yamamoto G, Sanada M, Nannya Y, Kikuchi A, Igarashi T, Ogawa S, Hayashi Y
    • Organizer
      Advances in Neuroblastoma Research
    • Place of Presentation
      Chiba
    • Year and Date
      20080521-20080524
  • [Book] 悪性腫瘍(五十嵐隆監修)(小児科学レビュー)2010

    • Author(s)
      滝田順子
    • Total Pages
      117-121
    • Publisher
      総合医学社
  • [Book] 先天性異常(臨床検査ガイド2009~2010)(Medical Practice編集委員会編)2009

    • Author(s)
      滝田順子、五十嵐隆
    • Total Pages
      1028-1030
    • Publisher
      文光堂
  • [Book] Advanced Neuroblastoma(Role of ALK mutations. Tumors of the central nervous system)(Ed.Eric Hayat)5 vol, USA

    • Author(s)
      Takita J, Ogawa S
    • Publisher
      series, Springer New York in press

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Published: 2012-01-26   Modified: 2016-04-21  

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