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2010 Fiscal Year Self-evaluation Report

Cell-selective particle radiotherapy for malignant brain tumor

Research Project

  • PDF
Project/Area Number 20390379
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

MATSUMURA Akira  University of Tsukuba, 大学院・人間総合科学研究科, 教授 (90241819)

Project Period (FY) 2008 – 2011
Keywordsグリオーマ / BNCT / 中性子
Research Abstract

(1)熱外中性子ビームと2 剤のホウ素化合物を用いて細胞選択的粒子線治療を行い、効果と安全性を明らかにする。
(2)適応を初発神経膠腫以外に拡大する。
(3)マルチリーフコリメーター、強度変調法に関するシミュレーション研究、核磁気共鳴スペクトロスコピー(MRS)によるホウ素化合物の定量を試みる。

  • Research Products

    (9 results)

All 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (1 results)

  • [Journal Article] 特集脳腫瘍研究の最前線-遺伝子解析から治療まで.悪性グリオーマに対する粒子線治療.2009

    • Author(s)
      山本哲哉, 坪井康次
    • Journal Title

      BRAIN and NERVE 61

      Pages: 855-866

    • Peer Reviewed
  • [Journal Article] PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma.2009

    • Author(s)
      Nariai T, Ishiwata K, Kimura Y, Inaji M, Momose T, Yamamoto T, Matsumura A, Ishii K, Ohno K.
    • Journal Title

      Appl Radiat Isot 67(7-8 Suppl)

      Pages: S348-S350

    • Peer Reviewed
  • [Journal Article] Dose distribution and clinical response of glioblastoma treated with external beam boron neutron capture therapy.2009

    • Author(s)
      Matsuda M, Yamamoto T, Kumada H, Nakai K, Shirakawa M, Tsurubuchi T, Matsumura A
    • Journal Title

      Appl Radiat Isot

      Pages: S19-S21

    • Peer Reviewed
  • [Journal Article] Current practices and future directions of therapeutic strategy in glioblastoma : survival benefit and indication of BNCT.2009

    • Author(s)
      Matsumura A, Yamamoto T, Tsurubuchi T, Matsuda M, Shirakawa M, Nakai K, Endo K, Tokuue K, Tsuboi K
    • Journal Title

      Appl Radiat Isot 67(7-8 Suppl)

      Pages: S12-S14

    • Peer Reviewed
  • [Journal Article] Feasibility of Boron Neutron Capture Therapy for malignant spinal tumors.2009

    • Author(s)
      Nakai K, Kumada H, Yamamoto T, Tsurubuchi T, Zaboronok A, Matsumura A
    • Journal Title

      Appl Radiat Isot 67(7-8 Suppl)

      Pages: S43-S46

    • Peer Reviewed
  • [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma.2009

    • Author(s)
      Yamamoto T, Nakai K, Kageji T, Kumada H, Endo K, Matsuda M, Shibata Y, Matsumura A
    • Journal Title

      Radiother Oncol 91

      Pages: 80-84

    • Peer Reviewed
  • [Journal Article] 膠芽腫に対する中性子捕捉療法.2008

    • Author(s)
      山本哲哉, 中井啓, 松村明
    • Journal Title

      No Shinkei Geka 36

      Pages: 293-302

    • Peer Reviewed
  • [Journal Article] Boron neutron capture therapy for glioblastoma.2008

    • Author(s)
      山本哲哉, 中井啓, 松村明
    • Journal Title

      Cancer letters 262

      Pages: 143-152

    • Peer Reviewed
  • [Presentation] BNCT and other emerging treatments for malignant glioma.2010

    • Author(s)
      Matsumura A, Yamamoto T, Ishikawa E, Nakai K, Endo K, Takano S, Shibata Y
    • Organizer
      14th International congress on neutron capture therapy
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-10-30

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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