Cell selective particle therapy for malignant brain tumor

2011 Fiscal Year Final Research Report

• Project/Area Number: 20390379
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: University of Tsukuba
• Principal Investigator: MATSUMURA Akira 筑波大学, 医学医療系, 教授 (90241819)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Tetsuya 筑波大学, 医学医療系, 講師 (30375505) ; KUMADA Hiroaki 筑波大学, 医学医療系, 准教授 (30354913) ; NAKAI Kei 筑波大学, 医学医療系, 講師 (50436284) ; ISOBE Tomonori 筑波大学, 医学医療系, 准教授 (70383643) ; NARIAI Tadashi 東京医科歯科大学, 医学部附属病院, 講師 (00228090)
• Project Period (FY): 2008 – 2011
• Keywords: 中性子捕捉療法

Research Abstract

We started BNCT for newly diagnosed glioblastoma and recurrent malignant brain tumor with the new protocol. In Newly diagnosed glioblastoma case, progression free survival was 13 month, and overall survival was 21month.In recurrent malignant brain tumor case, we perform BNCT for 2 cases. Recurrent glioblastoma case revealed radiation necrosis and skin necrosis but tumor was stable during 2 years of follow up period. Malignant meningioma case is recurrence free during 2 years of follow up period.

Research Products

• [Journal Article] Multistep Lattice-Voxel method utilizing lattice function for Monte-Carlo treatment planning with pixel based voxel model (2011)
  • Author(s): Kumada H, Saito K, Nakamura T, Sakae T, Sakurai H, Matsumura A, Ono K.
  • Journal Title: Appl Radiat Isot Volume: 69 Pages: 1866-1869
  • DOI: DOI:10.1016/j.apradiso.2011.03.023
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma : a recursive partitioning analysis of BNCT patients (2011)
  • Author(s): Nakai K, Yamamoto T, Aiyama H, Takada T, Yoshida F, Kageji T, Kumada H, Isobe T, Endo K, Matsuda M, Tsurubuchi T, Shibata Y, Takano S, Mizumoto M, Tsuboi K, Matsumura A
  • Journal Title: Appl Radiat Isot Volume: 69 Pages: 1790-1792
  • DOI: DOI:10.1016/j.apradiso.2011.03.049
  • Peer Reviewed
• [Journal Article] A clinical trial protocol for second line treatment of malignant brain tumors with BNCT at University of Tsukuba (2011)
  • Author(s): Aiyama H, Nakai K, Yamamoto T, Nariai T, Kumada H, Ishikawa E, Isobe T, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
  • Journal Title: Appl Radiat Isot Volume: 69 Pages: 1819-1822
  • DOI: DOI:10.1016/j.apradiso.2011.04.031
  • Peer Reviewed
• [Journal Article] the status of Tsukuba BNCT trial : BPA-based boron neutron capture therapy combined with X-ray irradiation (2011)
  • Author(s): Yamamoto T, Nakai K, Nariai T, Kumada H, Okumura T, Mizumoto M, Tsuboi K, Zaboronok A, Ishikawa E, Aiyama H, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
  • Journal Title: Appl Radiat Isot Volume: 69 Pages: 1817-1818
  • DOI: DOI:10.1016/j.apradiso.2011.02.013
  • Peer Reviewed
• [Journal Article] Prognostic factors in glioblastoma multiforme patients receiving high-dose particle radiotherapy or conventional radiotherapy (2011)
  • Author(s): Matsuda M, Yamamoto T, Ishikawa E, Nakai K, Zaboronok A, Takano S, Matsumura A
  • Journal Title: Br J Radiol Pages: 54-60
  • DOI: DOI:10.1259/bjr/29022270
  • Peer Reviewed
• [Journal Article] Applicationof the multi-model Monte-Carlo treatment planning system combined with PHITS to proton radiotherapy (2011)
  • Author(s): Kumada H, Sakae T, Saito K, Isobe T, Hashimoto T, Sakurai H
  • Journal Title: Prog Nucl Sci Technol Volume: 2 Pages: 213-218
  • Peer Reviewed
• [Journal Article] Feasibility of Boron Neutron Capture Therapy for malignant spinal tumors (2009)
  • Author(s): Nakai K, Kumada H, Yamamoto T, Tsurubuchi T, Zaboronok A, Matsumura A
  • Journal Title: Appl Radiat Isot Volume: 67 Pages: 43-46
  • Peer Reviewed
• [Journal Article] Current practices and future directions of therapeutic strategy in glioblastoma : survival benefit and indication of BNCT (2009)
  • Author(s): Matsumura A, et al
  • Journal Title: Appl Radiat Isot Volume: 67 Pages: 12-14
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma (2009)
  • Author(s): Yamamoto T, Nakai K, Kageji T, Kumada H, Endo K, Matsuda M, Shibata Y, Matsumura A
  • Journal Title: Radiother Oncol Volume: 91 Pages: 80-84
  • Peer Reviewed
• [Journal Article] 膠芽腫に対する中性子捕捉療法 (2008)
  • Author(s): 山本哲哉, 中井啓, 松村明
  • Journal Title: No Shinkei Geka Volume: 36 Pages: 293-302
  • Peer Reviewed
• [Presentation] Boron Neutron Capture Therapy for Glioblastoma (2011)
  • Author(s): Yamamoto T
  • Organizer: 6^<th> Young Researchers BNCT neeting
  • Place of Presentation: Hsunchu, Taiwan
  • Year and Date: 2011-12-05
• [Presentation] New Challenge for Advanced BNCT in university of Tsukuba (2011)
  • Author(s): Kumada H, Matsumura A, Sakurai H, Sakae T, Yoshioka M, Kobayashi H, Matsumoto H, Kiyanagi Y, Shibata T, Nakashima H
  • Organizer: 6^<th> Young Researchers BNCT neeting
  • Place of Presentation: Hsunchu, Taiwan
  • Year and Date: 2011-12-05
• [Presentation] Glioblastomaに対する高線量粒子線治療(BNCT, Proton)を含む新規集学的治療の取り組み。-QOLの維持と治療成績の改善を目指して-. (2011)
  • Author(s): 松村明, 山本哲哉, 中井啓, 熊田博明, 松田眞秀, 遠藤聖, 石川栄一, 高野晋吾, 坪井康次, 櫻井英幸, 村垣善浩
  • Organizer: 第70回日本脳神経外科学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-13
• [Presentation] 悪性脳腫瘍BNCTにおける最大皮膚線量と術後創傷治癒について (2011)
  • Author(s): 中井啓, 山本哲哉, 高田智也, 熊田博明, 松田真秀, 吉田文代, 遠藤聖, 相山仁, 高野晋吾, 松村明
  • Organizer: 第8日本中性子捕捉療法学会
  • Place of Presentation: 徳島
  • Year and Date: 2011-09-16
• [Presentation] High Dose Boron Neutron Capture Therapy (Alpha Particle Therapy) For Newly Diagnosed Glioblastoma (2011)
  • Author(s): Matsumura A, Yamamoto T, Nakai k, Takano S, Kumada H, Tsuboi K, Sakurai H
  • Organizer: Brain Tumor
  • Place of Presentation: Berlin
  • Year and Date: 2011-06-16
• [Presentation] BNCT and other emerging treatments for malignant glioma (2010)
  • Author(s): Matsumura A, et al
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-30
• [Presentation] Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma (2010)
  • Author(s): Nakai K, Yamamoto T, Kageji T, Kumada H, Endo K, Matsuda M, Tsurubuchi T, Shibata Y, Takano S, Matsumura A
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-28
• [Presentation] The status of Tsukuba BNCT trial : boron neutron capture therapy for recurrent glioma and malignant brain tumor (2010)
  • Author(s): Aiyama, H. K. Nakai, T. Yamamoto, T. Nariai, H. Kumada, E. Ishikawa, K. Endo, T. Takada, F. Yoshida, Y. Shibata, A. Matsumura
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-27
• [Presentation] The status of Tsukuba BNCT trial : BPA-based boron neutron capture therapy combined with X-ray irradiation (2010)
  • Author(s): Yamamoto T, Nakai K, Nariai T, Kumada H, Okumura T, Miszumoto M, Tuboi K, Zaboronok A, Ishikawa E, Aiyama H, Endo K, Takada T, Yoshida F, Shibata Y, Matsumura A
  • Organizer: 14th International congress on neutron capture therapy
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-10-26
• [Presentation] Clinical result and adjuvant therapy for glioblastoma with BNCT treated patients (2009)
  • Author(s): Nakai K, Ymamaoto T, Tsurubuchi T, Matsuda M, Shirakawa M, Endo K, Alexander Zabornok, Matsumura A, Kageji T
  • Organizer: Young researchers BNCT meeting
  • Place of Presentation: Mainz
  • Year and Date: 2009-09-30
• [Presentation] 初発神経膠芽腫に対する中性子捕捉療法:再開に向けて (2009)
  • Author(s): 中井啓, 山本哲哉, 遠藤聖, 柴田靖, 鶴淵隆夫, 松田真秀, 高野晋吾, 松村明, 熊田博明, 影治照喜
  • Organizer: 第6回日本ホウ素中性子捕捉療法学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-09-19
• [Presentation] Boron neutron capture therapy for newly-diagnosed glioblastoma : a pilot study in Tsukuba (2008)
  • Author(s): Yamamoto T, Nakai K, Tsurubuchi T, Matsuda M, Shirakawa M, Endo K, Matsumura A
  • Organizer: 13th International Congress of Neutron Capture Therapy
  • Place of Presentation: Florence, Italy
  • Year and Date: 2008-11-03
• [Book] Tumors of the Central Nervous System, Vol. 21st Edition., Chapter 25 (2011)
  • Author(s): Yamamoto T, Nakai K, Kumada H
  • Total Pages: 229-239
  • Publisher: Springer, Tumors of the Central Nervous System, Volume 2 Gliomas : Glioblastoma (Part 2) Series