2010 Fiscal Year Final Research Report
Role of the parafascicular-striatal projection in the anti-depressive effect of vagal nerve stimulation
| Project/Area Number |
20390385
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Shimane University |
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Principal Investigator |
ITO Shin-Ichi Shimane University, 医学部, 准教授 (10145295)
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Kohji 帝京大学, 文学部, 教授 (70100930)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 迷走神経刺激 / カフ電極 / 視床束傍核 / 強制水泳 / 恐怖条件付け / 抗うつ効果 / 抗不安効果 / 逆行性標識 |
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| Research Abstract |
A new implantable cuff electrode for vagus nerve stimulation (VNS) was developed. VNS was found to be effective to the treatment-resistant depression model based on fear conditioning. It was found that vagus input to the thalamic parafascicular nucleus was transmitted via medial subnucleus of the ipsilateral parabrachial nucleus. Effects of parafascicular lesion on the anti-depressant VNS effect is under investigation.
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