2010 Fiscal Year Final Research Report
New therapeutic strategy for cerebral ischemia using encapsulated neural stem cells
| Project/Area Number |
20390386
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
DATE Isao Okayama University, 大学院・医歯薬学総合研究科, 教授 (70236785)
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| Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Yasuyuki 岡山大学, 大学院・医歯薬学総合研究科, 講師 (00362997)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIU Kenji 岡山大学, 病院, 講師 (40325105)
TOKUNAGA Koji 岡山大学, 病院, 講師 (40294467)
ONO Shigeki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40335625)
ICHIKAWA Tomotsugu 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10362964)
KAMEDA Masahiro 岡山大学, 病院, 医員 (50586427)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脳血管障害学 / 脳卒中 / カプセル化細胞 / 細胞移植 / 栄養因子 |
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| Research Abstract |
We produced encapsulated neural stem cells with the scaffold using collagen type-I. We could find the survival of the neural stem cells in this capsule and could not find any tumor formations. We transplanted encapsulated neural stem cells into the middle cerebral artery occlusion model of rats. The transplanted rats could show better behavioral recovery and had smaller infarct area compared to the control rats. We also found that ischemic damage to the donor cells in transplantation could be reduced by pre-treatment with Glial cell line-derived neurotrophic factor (GDNF).
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Research Products
(75 results)
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[Journal Article] Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats : Focusing on neuroprotective effects of stromal cell-derived factor-1α2010
Author(s)
Wang F, Yasuhara T, Shingo T, Kameda M, Tajiri N, Yuan WJ, Kondo A, Kadota T, Baba T, Tayra JT, Kikuchi Y, Miyoshi Y, Date I
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Journal Title
BMC Neuroscience 11(52)
Pages: 1-9
Peer Reviewed
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[Journal Article] Urinary 8-OHdG elevations in a partial lesion rat model of Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion2010
Author(s)
Kikuchi Y, Yasuhara T, Agari T, Kondo A, Kuramoto S, Kameda M, Kadota T, Baba T, Tajiri N, Wang F, Tayra JT, Liang H, Miyoshi Y, Borlongan CV, Date I
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Journal Title
Journal of Cellular Physiology Oct 13:Epub
Peer Reviewed
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[Journal Article] Exercise exerts neuroprotective effects on Parkinson's disease model of rats2010
Author(s)
Tajiri N, Yasuhara T, Shingo T, Kondo A, Yuan W, Kadota T, Wang F, Baba T, Tayra JT, Morimoto T, Jing M, Kikuchi Y, Kuramoto S, Agari T, Miyoshi Y, Fujino H, Obata F, Takeda I, Furuta T, Date I
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Journal Title
Brain Research 1310
Pages: 200-207
Peer Reviewed
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[Journal Article] Continuous intraventricular infusion of erythropoietin exerts neuroprotective/rescue effects upon Parkinson's disease model of rats with enhanced neurogenesis.2009
Author(s)
Kadota T, Shingo T, Yasuhara T, Tajiri N, Kondo A, Morimoto T, Yuan WJ, Wang F, Baba T, Tokunaga K, Miyoshi Y,, Date I
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Journal Title
Brain Research 1254
Pages: 120-127
Peer Reviewed
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[Journal Article] The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting.2009
Author(s)
Jing M, Shingo T, Yasuhara T, Kondo A, Morimoto T, Wang F, Baba T, Yuan WJ, Tajiri N, Uozumi T, Murakami M, Tanabe M, Miyoshi Y, Zhao S, Date I
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Journal Title
Brain Res 1295
Pages: 203-217
Peer Reviewed
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[Journal Article] Electrical stimulation of the cerebral cortex exerts antiapoptotic, angiogenic, and anti-inflammatory effects in ischemic stroke rats through phosphoinositide 3-kinase/akt signaling pathway2009
Author(s)
Baba T, Kameda M, Yasuhara T, Morimoto T, Kondo A, Shingo T, Tajiri N, Wang F, Miyoshi Y, Borlongan CV, Matumae M, Date I
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Journal Title
Stroke published online Sep 17
Peer Reviewed
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[Journal Article] Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons.2008
Author(s)
Yuan WJ, Yasuhara T, Shingo T, Muraoka K, Agari T, Kameda M, Uozumi T, Tajiri N, Morimoto T, Jing M, Baba T, Wang F, Leung H, Matsui T, Miyoshi Y, Date I
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Journal Title
BioMedCentral Neurosciences 9
Pages: 75
Peer Reviewed
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[Journal Article] Embryonic neural stem cells transplanted in middle cerebral artery occlusion model of rats demonstrated potent therapeutic effects, compared to adult neural stem cells2008
Author(s)
Takahashi K, Yasuhara T, Shingo T, Muraoka K, Kameda M, Takeuchi A, Yano A, Kurozumi K, Agari T, Miyoshi Y, Kinugasa K, Date I.
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Journal Title
Brain Res 1234
Pages: 172-182
Peer Reviewed
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