2010 Fiscal Year Final Research Report
Non-coding RNAs regulating cartilage development
| Project/Area Number |
20390409
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
ASAHARA Hiroshi National Research Institute for Child Health and Development, システム発生・再生医学研究部, 部長 (70294460)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAKI Shigeru 独立行政法人国立成育医療研究センター, システム発生・再生医学研究部, 研究員 (10392490)
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| Research Collaborator |
KUDO Hiroe (上野 寛枝) 独立行政法人国立成育医療研究センター, システム発生・再生医学研究部, 共同研究員 (20425713)
SATO Tempei 独立行政法人国立成育医療研究センター, システム発生・再生医学研究部, 共同研究員 (00571944)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 関節病学 / 軟骨 / マイクロRNA |
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| Research Abstract |
We examined the expression pattern of miRNAs in chondrogenesis and found that miR-140 is specifically expressed in cartilage. Loss and gain of function experiments of miR-140 indicated that miR-140 is critical for both cartilage development and homeostasis, partly via regulating Adamts-5.
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[Journal Article] MicroRNA-140 plays dual roles in both cartilage development and homeostasis.2010
Author(s)
Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S, Takada S, Lotz MK, Ueno-Kudo H, Asahara H.
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Journal Title
Genes Dev. 24(11)
Pages: 1173-1185
Peer Reviewed
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